Process Development Division Area 12B -Pilot Plants

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Process Development Division Area 12B -Pilot
Plants

• AIChE 2006 Fall Meeting
• San Francisco, CA

Monday 11/13/2006 630-730 PM Hilton (Union
Square 11 4th floor)
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AGENDA

• Introductions
• Mission Statement Review
• Area Leadership
• Programming Review (2006 - 2008)
• Future Programming Topics Open Forum
• Current Action Items
• New Business
• Area 12b Leadership Roles

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Mission Statement

• The Pilot Plant Area is a forum for active
  interchange of ideas and for the continual
  improvement of Pilot Plant contributions to
  quality research and effective scale-up.
• AIChE programming, benchmarking, operation
  reviews, and extensive networking form the
  backbone of the Area activities.

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Area 12B Leadership Elections

• Chair Joe Powell, Shell
• Chair-Elect Dan Pintar, UOP
• Activities Chair Adam Whalley, Zeton
• Past Chair David Edwards, Zeton

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Programming.

• Spring 2006 (Orlando, FL)
• Pilot Plant Success Stories
• Chair David Edwards
• Vice-Chair Raymond Rooks
• 4-Session Mini-Topical for 12A SEF
  Sustainability in Practice
• Joe Powell, chair
• Book to be drafted

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Programming.

• Fall 2006 (San Francisco, CA)
• Pilot Plants Mini-Topical Pilot Plant Design
  and Optimization
• Chairs Dan Pintar, Joe Powell
• Unit Operations Scale Up and Scale-down in
  Pilot Plants
• Joe Powell, Osman Aboul-Nasr
• Pilot Plants in the Food and Consumer Products
  Industries
• Marc Privitera, David Reeder
• Strategies in Biopharmaceutical Scale-up Pilot
  Plants
• Nihal Tugcu (15b), Adam Whalley (12b)
• Poster Session Pictures of Pilot Plants and
  University Unit Operation Labs
• John Corn

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Monday, 13 November 2006 830 AM-1100 AM Union
Square 25 (Hilton San Francisco) Topical 5
Pilot Plant Design and Optimization (T5) 52
- Unit Operations Scale up and Scale-down in
Pilot Plants (T5002) Chair Joseph B.
Powell CoChair Osman Aboul-Nasr CoSponsor(s) P
ilot Plants (12b) 830 AM   Introductory
Remarks 835 AM 52a Pilot Plant Testing Results
in Successful Liquid-Liquid Extraction
Scale-upDonald J. Glatz, Wendy Parker 900
AM 52b Pilot Plant Politics Scaling up from
Small Pilot Plants to Commercial Production
PlantsJonathan H. Worstell, David S. Brown 925
AM 52c Reactor Scale-down for Pilot Plant, Bench
Scale, and Multi-Throughput UnitsJoseph B.
Powell 950 AM 52d Scaling Two Phase Batch and
Semi-Batch Chemical Processes from Laboratory
Scale to Commercial ScaleJonathan H.
Worstell 1015 AM 52e Development of an
Adsorption Model Using Aspen Custom Modeler as a
Troubleshooting and Optimization Tool for Plant
ProcessesSalvador Aldrett, Jonathan H.
Worstell 1040 AM   Concluding Remarks
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Monday, 13 November 2006 315 PM-545 PM Union
Square 25 (Hilton San Francisco) Topical 5
Pilot Plant Design and Optimization (T5) 151
Strategies in Biopharmaceutical Scale-up Pilot
Plants (T5003) Chair Nihal Tugcu CoChair Adam
Whalley CoSponsor(s) Pilot Plants
(12b)Pharmaceuticals (See also Topical 2)
(15b)Topical 2 Discover, Development and
Delivery of Medicines (T2) 315
PM   Introductory Remarks Part 1   320
PM 151a Cell Culture Scale-up and Technology
Transfer for 12,000 L-Scale Therapeutic Antibody
ManufacturingJohn Fann, John Ponzo, Ziran Sun,
Seshu Tummala, Clara Teijido, Min Wan, George
Avgerinos 341 PM 151b Strategy to Fit a
Downstream Purification Platform for an Early
Stage Development, Therapeutic Protein into an
Existing Pilot PlantFrancis M. Torres, Nguyen V.
Ly 402 PM 151c The Role of Process Modeling in
Bioprocess Development and Technology
TransferCharles Siletti, Demetri P.
Petrides 423 PM 151e Multi-Dimensional Model
for Prediction and Scale-up of LyophilizationPavo
l Rajniak, Jiri Placek, Joseph Schaller, Rajiv
Mahajan, Rey Chern 444 PM 151f Scale up of
Fluid Mixing Parameters in Bio-Pharmaceutical
ProcessesJames Y. Oldshue 505 PM 151g From
Petrochemicals to Pharmaceuticals Rapid Scale-up
of Penicillin by an Academia-Industry Consortium
Including Shell Development Company during World
War IIJoseph B. Powell
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Monday, 13 November 2006 630 PM-900 PM Grand
Ballroom B (Hilton San Francisco) Topical 5
Pilot Plant Design and Optimization
(T5) 161 - Pictures of Pilot Plants and
University Unit Operation Labs (T5001) A picture
is worth a 1000 words... for some of us, that is.
One can also use a picture to help focus a
discussion on pilot plant operations and
undergaraduate engineering laboratory education.
The aim of this poster session is to allow lively
small group discussions and to help inform a
cohort of laboratory directors and workers about
pilot plant systems and/or University Unit
Operations Labs. Chair John Corn 161a Pilot
Plant for Distillation and Extraction
TestingDonald J. Glatz, Lori Mason 161b Pilot
Plants for the Chemical Process Industry
(2)Jeanette Beard 161c The Ohio State
University -- Chem Engr Ug Teaching LabJohn
Corn 161d Unit Operations at the University of
Illinois Urbana-ChampaignMarina
Miletic 161e Scale down Unusual "Pilot Plants"
and Unit OpsJoseph B. Powell 161f The
Undergraduate Laboratories at University of Notre
DameSalma Saddawi, Special, Profess 161g Abbott
Laboratories Fermentation and Separation Pilot
PlantsAnnette A. Johnston
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Tuesday, 14 November 2006 830 AM-1100 AM Van
Ness (Hilton San Francisco) Topical 5 Pilot
Plant Design and Optimization (T5) 198 -
Pilot Plants in the Food and Consumer Products
Industries (T5000) Pilot plants as normally
thought of in the chemical industry, but there
are similar needs in the Food and Consumer
Products Industries. This session will seek to
present pilot plant and process development
examples from this important industry
segment. Chair Marc Privitera CoChair David
Reeder CoSponsor(s) Pilot Plants (12b) 830
AM   Introductory Remarks 835 AM 198a Pilot
Plants Scaling down from Commercial Production
PlantsMike J. Doll, Jonathan H. Worstell 900
AM 198b Unique Pilot Plant Capabilities in the
Canadian PrairieGregg M. Willie 925
AM 198c Food and Chemical Pilot Plants What
Are the Differences?Richard Hess 950
AM 198d Using Pilot Plants Creatively to Reduce
Product Development Cycle TimeJonathan H.
Worstell 1015 AM 198e Re-Use of Pilot Plants
to Meet Consumer Products Feedstock
DemandsJoseph B. Powell 1040 AM   Concluding
Remarks
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Programming.

• Spring 2007 (Houston, TX)
• Tools and Best Practices in Pilot Plants
• Chair Joe Powell (Shell)
• Co-Chair David Attride (Eastman)
• Call for papers open until Nov. 30
• SUSTAINABLE Manufacturing
• Chair Joe Powell (Shell)
• Co-Chair Benson Pair (KBR)
• Co-sponsor SEF 12d
• Call for papers open until Nov. 30

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Programming.

• Fall 2007 (Salt Lake City, UT)
• Solids Handling in Pilot Plants
• Bruce Hook (Dow)
• Vice Chair Joe Powell (Shell)
• Careers in Pilot Plants
• Chair Dan Pintar (UOP)
• Vice-Chair Salvador Aldrett (Shell)
• Alternative-Fuel Pilot Plants Process
  Development
• Chair David Reeder (Cargill)
• Vice-Chair Lissa Morgenthaler-Jones (LiveFuels)
• Mixing in Pilot Plants Co-Sponsored by NAMF
  (Group 6)
• Chair David Dickey (Mix Tech)
• Vice-Chair Tony Cartolano (Air Products)

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Fall 2007 or 2008 (TBA)

• Pharmaceutical Pilot Plants (tentative)
• Chair Brent Nielsen (Bristol-Myers Squibb)
• Co-Chair Elizabeth Spiteri (Bristol-Myers
  Squibb)
• Possible multiple sessions (4 topical)

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Programming.

• Spring 2008 (New Orleans, LA)
• Current Challenges in Pilot Plant Operation
• Chair Bob Duggal (Afton) or Cawas Cooper or
  Tony Cartolano (Air Products).
• Co-Chair Adam Whalley (Zeton)
• Process Chemistry and Catalysis in Pilot Plants
  (ACS overlap)
• Chair Joe Powell (Shell)
• Co-Chair David Attride (Eastman)
• Gasification pyrolysis pilot plants
• Chair David Edwards (Zeton)
• Co-Chair Dan Pintar (UOP)

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Programming.

• Fall 2008 (Philadelphia, PA)
• Session topics or topical conference to be chosen
  to coincide with AIChEs centenary celebrations
• Pilot Plant Centenary Celebration Topical David
  Edwards (Zeton) / Jean Tom (Bristol-Myers Squibb)
  topical chairs
• Instrumentation and control
• Chair David Edwards Co-chair (TBA?)
• Pharmaceuticals (chiral catalysis, separations)
• Chair Jeam Tom Co-chair (TBA?)
• Reaction engineering / reactor design
• Chair (TBA? Sue Degaleesan- Shell?) Co-Chair
  (TBA?)
• Pilot Plants through History? Pictures How
  technology has changed.
• Chair TBA?
• Co-Chair TBA?
• Consider Rich Palluzi short course? ½-day
  course? Part of topical

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Programming.

• Spring 2009 (Location TBA)
• Shortcut Methodology in Pilot Plants
• Chair Joe Powell, Shell
• Co-Chair Dan Pintar, UOP
• Heavy oil upgrading, hydrotreating refining
  pilot plants
• Adam Whalley (Zeton)
• Dan Pintar (UOP)

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Programming.

• Fall 2009 (Location TBA)
• Biotech and Biopharma Pilot Plants
• Misti Ushio (Merck 12b), Vice Chair (15c)
• Pilot Plant Metrics and Productivity
• Chair, Vice Chair (TBA)

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Potential Session Topics...

• Analytical techniques/devices for pilot plants
• Pharmaceutical pilot plants - regulations and
  environmental challenges
• Process safety management in pilot plants
• Bio-informatics/Bio-technology
• Generic drugs and related topics
• Bio-processing
• Bio-tech Pilot Plants
• Polymer Processing in Pilot Plants
• Syngas Pilot Plants
• Contract Pilot Plants (contracting either as a
  supplier of pilot plant services or a client)
• Constructability issues for Pilot Plants
• Careers in Pilot Plants
• Microbiological and Cleanliness Challenges in
  Pilot Plants
• Internal Contract Vs. Toll Pilot Plants
• Novel reaction techniques in Pilot Plants (e.g.
  microwave)
• Pilot Plant metrics and productivity

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Potential Session Topics

• Miniaturization of Pilot Plants
• Cost-Driven Pilot Plants (Funding)
• Process Control and Data Acquisition in Pilot
  Plants
• Marketing of Pilot Plants (internal see next
  topic or External for purposes of contracting
  services)
• Time-to-Market
• Successful Pilot Plant Design
• Pilot Plant Productivity (Metrics used to define
  equipment/personnel/reliability)
• Pilot Plants as Part of the Corporate
  Structure/Organization
• Optimum Sizing of Pilot Plants
• Internal or Contract Pilot Plants ?
• Pilot Plant Tools and Techniques
• Pilot Plant Equipment Selection
• Use of Computer Simulation to Support Pilot Plant
  Design and Operation

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Current Action Items

• Oversee Chemical Process Development Web Forum
  and Vendor Area (DE)hosted on www.eng-tips.com
• Opportunities for courses include ASME and Univ.
  of Wisconsin continuing education. No interest
  in developing AIChE sponsored course at this
  time.
• Publish Pilot Plant Benchmarking results in CEP
  (JBP / BD) ongoing

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New Business

• Solicit session chairs and co-chairs for 2007-09
  (done)
• Vote Adam Whalley (Zeton) elected as 12b
  activities chair
• Possible Process Development or Pilot Plant Best
  Practices Edited Book (Wiley)
• Publish pilot plant benchmarking first
• forward chapter proposal to Joe.Powell_at_Shell.com
  if interested.

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Area 12b Leadership Roles
Area 12b Past Chair The Area 12b Past Chair
oversees the handover of action items and
responsibilities to the incoming Area 12b Chair,
and supports and advises the Area 12b Chair
during his/her two year term as necessary.
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Area 12b Leadership Roles

• Area 12b Chair
• The Area 12b Chair leads all Area 12b activities,
  and has overall responsibility for ensuring all
  phases of programming for Area 12b.
• Automatically assumes Area Chair position at the
  beginning of the annual (Fall) meeting in odd
  years after serving as Chair-Elect for two years.
• Is responsible for selection of technical session
  topics in coordination with the Division
  Programming chair, and for finding chairs and
  co-chairs for these sessions.

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Area 12b Leadership Roles

• Area 12b Chair Contd.
• Coordinates and helps session chairs in
  organizing sessions and meeting deadlines.
• Develops the Area in accordance with the Area
  Mission Statement.
• Holds Area meetings at least once a year at the
  Annual or Spring Meeting.
• Holds an Area election at the Steering Committee
  meeting upon leaving office for the incoming
  Activities Chair position before handing over
  responsibilities to the Chair-Elect.
• Provides leadership and management for the Area.

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Area 12b Leadership Roles

• Area 12b Chair-Elect
• The Area 12b Chair-Elect prepares for the office
  of Chair by assisting the Area 12b Chair during
  his/her two year term.
• Deputizes for the Area 12b Chair in the Chair's
  absence or inability to serve.
• Automatically assumes the position of Area 12b
  Chair at the beginning of the annual (Fall)
  meeting in odd years after serving for two years
  as Area 12b Chair-Elect.
• Formulates long-term plans and strategic
  activities for the Area in accordance with the
  Area Mission Statement.
• Assist session chairs and co-chairs with finding
  presenters for 12b sessions.

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Area 12b Leadership Roles

• Area 12b Activities Chair
• The Area 12b Activities Chair prepares for the
  office of Chair-Elect during his/her two year
  term. This position requires no prior experience
  in AIChE/PD Division or Area matters.
• Is recruited by the outgoing Area 12b
  Chair-Elect, and is elected to office during Area
  Elections at the annual (Fall) meeting in odd
  years.
• Automatically assumes the position of Area 12b
  Chair-Elect at the annual (Fall) meeting in odd
  years after serving for two years as Area 12b
  Activities Chair.
• Assist session chairs and co-chairs with finding
  presenters for 12b sessions.