Hemodynamic Disorders Thrombosis and Shock Dr. Daniel May

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Hemodynamic DisordersThrombosis and Shock

• Dr. Daniel May

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Edema due to Poison Oak exposure
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Pulmonary effusion
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Ascites
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Ankle edema
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Lip and eyelid edema
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Conjunctival Hyperemia
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Subconjunctival hemorrhage
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Hematoma of the leg
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Subungal hematoma
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Petechial hemorrhages in the colon

• Intracerebral hemorrhage

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Henoch-Schönlein Purpura
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Normal Hemostasis
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Normal Hemostasis
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Virchows Triad in Thrombosis
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Table 4-2. Hypercoagulable States

• Primary (Genetic)
• Common 
• Mutation in factor V gene (factor V Leiden)  
• Mutation in prothrombin gene  
• Mutation in methyltetrahydrofolate gene
• Rare  
• Antithrombin III deficiency  
• Protein C deficiency  
• Protein S deficiency
• Very rare  
• Fibrinolysis defects

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Table 4-2. Hypercoagulable States

• Secondary (Acquired)
• High risk for thrombosis 
• Prolonged bedrest or immobilization  
• Myocardial infarction  
• Atrial fibrillation  
• Tissue damage (surgery, fracture, burns)  
• Cancer  
• Prosthetic cardiac valves  
• Disseminated intravascular coagulation  
• Heparin-induced thrombocytopenia  
• Antiphospholipid antibody syndrome (lupus
  anticoagulant syndrome)

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Table 4-2. Hypercoagulable States

• Secondary (Acquired)
• Lower risk for thrombosis  
• Cardiomyopathy  
• Nephrotic syndrome  
• Hyperestrogenic states (pregnancy)  
• Oral contraceptive use  
• Sickle cell anemia  
• Smoking

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A Hemorrhagic wedge shaped infarct of the
lung (red infarct)
B Pale infarct of the spleen (white infarct)
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Previous infarct of the kidney - now replaced by
a large fibrotic scar