Acrylamide in Food Workshop

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Acrylamide in Food Workshop

• Contaminants and Natural Toxicants Subcommittee
• FDA Food Advisory Committee
• College Park, MD
• December 4, 2002

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Background

• Ad hoc Acrylamide Working group composed for food
  industry, trade associations, academic and
  government representatives
• Began discussions shortly after Swedish release
  in April
• Workshop, concentrating on science, was needed to
  openly discuss issues.

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Acrylamide in Food Workshop

• Title Acrylamide in Food Scientific Issues,
  Uncertainties, and Research Strategies
• Dates October 28-30, 2002
• Location OHare Ramada Plaza Hotel, Chicago

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Acrylamide in Food Workshop

• Focus Science knowledge gaps and research
  priorities
• Target audience
• Food industry
• Academia
• Regulatory agencies (domestic and
  international)

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Goals/Objectives

• To develop conclusions on how efforts of
  industry, government, and academia can be
  coordinated to effectively use available
  resources to address the scientific issues raised
  by the reports of acrylamide in foods, including
  the final report of the WHO/FAO Consultation.

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Goals/Objectives

• Identify data gaps in scientific knowledge to
  reflect an international perspective, to the
  extent possible
• Identify research needs
• Identify a select number of high-priority
  research needs to be included in a coordinated
  research agenda
• Workshop Planning Committee to identify list of
  short-term action items.

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Participants

• 170 present out of 171 acceptances
• About 25 from outside the U.S. including
• Laurance Castle, CSL, UK
• Bryan Hanley, Leatherhead Food RA, UK
• Karl-Erik Hellenas, Swedish Natl. FA
• Hans Lingnert, SIK, Sweden
• Manfred Leutzow, FAO, Rome
• Dennis Marroni, SNF-Floeger, France

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Participants

• Donald Mottram, Univ. of Reading, UK
• Mayumi Onishi-Kameyama, NFRI, Japan
• Nadia Slimani, IARC/WHO, France
• Margareta Tornqvist, Stockholm Univ.
• Richard Stadler, Nestle Res. Ctr, Switzerland
• Peter Varelis, CSIRO, Sydney
• Carolyn Vickers, WHO, Geneva
• Mitsuni Ito Yoshida, NFRI, Japan
• Adam Becalski, Health Canada

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Working Groups

• Mechanisms of formation of acrylamide in food
• Analytical methods
• Exposure and biomarkers
• Toxicology and metabolic consequences
• Risk communication

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Questions Addressed by Each Working Group

• What are the primary areas concerning the
  occurrence of acryamide in food in which research
  is needed?
• Are methods currently available to accomplish
  this research?
• What is the time frame for getting results for
  the research identified?

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Questions Addressed by Each Working Group

• What missing information is needed to enable the
  proposed research to be initiated or
  accomplished?
• What questions will be answered by each research
  area proposed?
• Rank the research areas/projects identified in
  order of priority for accomplishment?

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Questions Addressed by Each Working Group

• 7. Where is your Working Group linked to others,
  i.e., from what other Working Groups do you need
  assistance?

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Workshop Proceedings

• The proceedings of the workshop are posted on the
  JIFSAN website (http//www.jifsan.umd.edu) and
  include an introduction, the workshop opening
  overview, the strawman position paper summary
  of discussions - conclusions from each Working
  Group, the priority research needs identified, a
  listing of short-term items, and a listing of
  participants.

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Short-term Action Items Priority areas and
projects

• Analytical Methods
• Establish proficiency testing program and
  materials.
• Toxicology
• Develop data on the absorption, distribution,
  metabolism, excretion of acrylamide
• Develop and conduct studies on DNAprotein
  glycidamide and acrylamide adducts to determine
  metabolic consequences of acrylamide.

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Short-term Action Items Priority areas and
projects

• Methods of Formation
• Develop data for various foods on quantity of
  free aspargine for various foods and data on the
  quantity of glucose, fructose (and other sugars)
  and other amino acids.
• Develop data on time/temperature/ph/moisture/surfa
  ce area-mass mapping and the kinetics of
  asparagine/carbonyls reactions in various matrices

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Short-term Action Items Priority areas and
projects

• Methods of Formation
• Define the direct relation of asparagine to
  acrylamide production in foods.
• Develop data on the kinetics of acrylamide
  inhibition/destruction/scavenging under various
  reaction/process conditions.

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Short-term Action Items Priority areas and
projects

• Exposure
• Expand the database of acrylamide levels in U.S.
  foods through collection of additional data and
  establish mechanisms for information sharing,
  such as the WHO/FAO Acrylamide in Food Network
  operated by JIFSAN through its Food Safety Risk
  Analysis Clearinghouse.
• Develop and conduct appropriate animal and/or
  human studies on the bioavailability of
  acrylamide in foods.

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Short-term Action Items Priority areas and
projects

• Risk Communication
• Conduct qualitative attitudinal research on
  consumer awareness and knowledge of acrylamide in
  food. Triggers for behavioral change may be
  identified for acrylamide and other potential
  health hazards.
• Formally document the unique process used to
  develop and accomplish the Acrylamide in Food
  Workshop.

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Short-term Action Items Priority areas and
projects

• Risk Communication
• Establish an information clearing house and
  evidence review process with full participation
  by a broad group of stakeholders. The WHO/FAO
  Acrylamide in Food Network provides the starting
  foundation for this.

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Acrylamide Infonet (WHO/FAO Acrylamide in Food
Network)

• Operated by JIFSAN (http//www.acrylamide-food.org
  )
• The objectives are
• Phase 1 to function as a global resource
  inventory of ongoing research, surveillance
  monitoring, industry investigations, etc.
• Serve as a discussion forum and network for
  active researchers/others in the field in order
  to identify gaps and overlaps in research
  information, and make suggestions for how these
  could be addressed

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Acrylamide EC Meeting

• In Europe, the EC organized a stakeholder
  meeting on October 15-16 for similar purposes to
  the JIFSAN/NCFST workshop in the U.S. The SCF
  and WHO/JECFA will be leading the work on
  toxicology and bioavailability, risk
  characterization and communication the CIAA will
  coordinate the industry input and be their link
  with the Commission and with international
  organizations.

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Acrylamide EC Meeting Cooperative Activity

• Key Issue USA Europe
• Analysis NFPA CIAA, Nat. author./
• assocns (Nat. a/a)
• Formation IIT, NCFS CIAA, Nat. a/a
• Exposure/ CIAA, Nat. a/a,
• Bioavailability GMA ILSI (Europe)
• Toxicology ILSI (NA) ILSI (Europe)
• Risk Commun. IFIC EUFIC

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