Parkinson

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Parkinsons Plus

• By Glen Estrosos

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Parkinsons Plus

• Many neurological disorders share features of
  Parkinson's disease.
• Parkinson's plus syndromes (PD Plus) include some
  signs of Parkinson's disease, as well as
  additional symptoms such as inappropriate eye
  movement control (progressive supranuclear
  palsy), autonomic dysfunction (multiple system
  atrophy), muscle weakness and atrophy, profound
  memory difficulties and behavioral disturbances,
  and others.

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People with Parkinsons
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Under the Umbrella
Progressive supranuclear palsy
Corticobasal degeneration

• Multiple system atrophy
• Olivopontocerebellaratrophy
• Dementia with Lewy bodies

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Etiology / Pathophysiology

• Multiple system atrophy (MSA) is a
  neurodegenerative disease characterized by
  parkinsonism, cerebellar dysfunction, and
  autonomic disturbances.
• Progressive supranuclear palsy (PSP) is a rare
  degenerative disorder that causes serious and
  permanent deficits in movement and cognitive
  function.

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Etiology / Pathophysiology

• Corticobasal degeneration (CBD) is a rare,
  progressive, neurodegenerative disease that
  causes movement disorders and dementia.
• Dementia with Lewy Bodies (DLB) exhibits clinical
  overlap between Alzheimer's disease and
  Parkinsons disease.
• Olivopontocerebellar atrophy (OPCA) is a group of
  disorders characterized by degeneration of three
  brain areas the inferior olives, the pons, and
  the cerebellum. OPCA causes increasingly severe
  ataxia (loss of coordination) as well as other
  symptoms.

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• It is said by neurologists that patients
  presenting with falls early in the course of a
  Parkinsonian illness are more likely to have a
  Parkinson-plus syndrome than idiopathic
  Parkinson's disease.
• The Parkinson-plus syndromes are usually more
  rapidly progressive and less likely to respond to
  anti-parkinsonian medication than Parkinson's
  disease. However, the additional features of the
  diseases may respond to medications not used in
  Parkinson's disease.

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