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Parenteral Drug Administration

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Parenteral Drug Administration Department of Anaesthesia University of Glasgow Parenteral Route in Dentistry General Dental Council Intravenous sedation drugs ... – PowerPoint PPT presentation

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Title: Parenteral Drug Administration


1
Parenteral Drug Administration
  • Department of Anaesthesia
  • University of Glasgow

2
Parenteral Route in Dentistry
  • General Dental Council
  • Intravenous sedation drugs
  • Emergency drugs

3
Drug Administration
subcutanous
oral
intramuscular
topical
intravenous
Absorbtion
Site of Action
Tissue
Plasma water
Metabolism
Excretion
4
Parenteral Injection Sites
subcutanously
intramuscularly
intravenously
5
Subcutaneous Route
  • Absorption depending on blood flow
  • Constant slow absorption
  • Prolonged effect
  • Drugs
  • Insulin
  • Heparin

6
Subcutaneous Injection Sites
  • Abdominal wall
  • Thigh
  • Deltoid area

7
Intramuscular Route
  • Absorption depending on blood flow
  • Rapid onset shorter duration
  • Shock
  • Drugs
  • Glucagon
  • Adrenaline

8
Intramuscular Injection Sites
9
Intramuscular Injection Sites
10
Intramuscular Injection Sites
11
Intramuscular Route
  • Limitations
  • Neurovascular damage
  • Bleeding (eg anticoagulant therapy)
  • Pain
  • Infection
  • Delayed absorption in shock
  • Interpretation of diagnostic tests

12
Intravenous Route
  • Rapid immediate onset
  • Permits titration
  • Administer slowly
  • Drugs
  • Midazolam

13
Intravenous Injection Sites
  • Peripheral
  • Central

14
Intravenous
  • Limitations
  • May be more difficult to obtain
  • Increased risk of adverse effects
  • Requires intravenous access
  • Infection
  • Pain

15
Anaphylaxis
  • Definition
  • Immunologically mediated reaction to antigen
    causing systemic symptoms
  • Potentially life threatening
  • Frequent Antigens
  • Antibiotics
  • Latex
  • Anaesthetic agents
  • Colloid fluids

16
Anaphylaxis
  • Diagnosis
  • Collapse
  • Difficulty breathing
  • Wheeze
  • Angio-oedema
  • Urticaria

17
Management Anaphylaxis
  • Prevention
  • Avoid unnecessary drugs particularly iv
  • Take drug history
  • Adequate staff training and facilities

18
Immediate Management 1
  • Remove trigger agent
  • Stop injection or infusion of drug
  • Remove triggering materials
  • Remember latex allergy
  • Chlorhexidine
  • Summon assistance

19
Immediate Management 2
  • Basic life support
  • Check airway, breathing, circulation
  • Oxygen
  • Give adrenaline (0.5-1mg im)
  • Elevate legs
  • (Give intravenous fluids)

20
Subsequent Management
  • Antihistamines
  • Chlorpheniramine iv
  • Steroids
  • Hydrocortisone iv
  • Intensive care unit
  • Immunological Testing

21
Summary
  • Parenteral drug administration
  • Sites
  • Drug availability
  • Limitations
  • Anaphylaxis

22
Questions ?
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