General Pathology: Introduction to the Course

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General PathologyIntroduction to the Course

• Lorne Holland, M.D.
• Lorne.Holland_at_ucdenver.edu

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General Information

• COURSE DIRECTOR
• Lorne Holland, M.D.
• Leprino Office Building, Main Laboratory- Rm
  280
• Email Lorne.Holland_at_ucdenver.edu
• Office [phone]
• ADMINISTRATIVE COORDINATOR
• Jaime Kean
• Building A01 Room L15-2203
• Email Jamie.Kean_at_ucdenver.edu
• Phone [phone]

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Map
Leprino Office Building
Parking Garage
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Exams

• Sample questions will periodically be posted on
  Blackboard with answers following shortly
• Before each exam there will be a QA session
• This is an opportunity for you to ask questions
  about the material
• This is not meant to be a formal review of all
  lecture material
• For best responses, please send me your
  question(s) a day or two in advance so I know
  what to expect

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Exams

• Multiple-choice, single best answer
• 2-3 questions per lecture
• Mid-October and December 17th
• 2nd exam is cumulative with approximately 80 new
  and 20 old
• Exams will be timed with 1.5 minutes allotted for
  each question

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Exams

• How much does a normal human head weigh?
• More than twice the average orange
• Between 4.4 and 5.3 kilograms
• Hair is typically 0.2 to 1.1 of head weight
• It would weigh only 1/6th as much on the moon

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Exams

• Review session immediately after
• Answers will be projected
• Your chance to ask questions
• Only opportunity to review test answers

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Exams

• Grading
• Tests are sent to the computer center for grading
  where they calculate statistics for each question
• A few questions will have bad numbers and will
  be thrown out
• Too hard or too easy
• Random answer pattern

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Other Tests

• Independent study questions
• Posted on Blackboard and due Sept 28th
• May collaborate, but each student must submit
  their own answers
• Remember, this material is fair game for both
  exams
• Periodic, unannounced quizzes
• Multiple-choice, single best answer and/or short
  answer
• You can use class notes and textbook
• Students not present when the quizzes are handed
  out will receive a zero
• Lowest quiz score will be dropped

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Objectives

• Each lecture will have a set of objectives
• This is the bare minimum you should be getting
  out of each lecture
• If you can not perform the objectives then it is
  unlikely you will pass
• If you only know material specifically addressed
  by the objectives, you will probably pass, but
  only barely (70-80)

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Odds and Ends

• Lecture handouts should be available on
  Blackboard 48 hrs before lecture
• Exam dates will be firm, but lectures may
  occasionally move around a bit. You should have
  at least 24 hrs warning.
• Please address questions directly to the
  lecturer. If you do not receive a response
  within 48 hrs then let me know
• Evaluations after each test. Please complete
  them so I know what is working and what is not

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Scope of Pathology
Pathology
Clinical
Experimental
Anatomic
laboratory medicine
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Scope of Pathology
Pathology
Clinical
Experimental
Anatomic
Pathogenesis
Etiology
Epidemiology
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Scope of Pathology
Pathology
Clinical
Experimental
Anatomic
Surgical
Gross / Micro
Gross / Micro
Autopsy
Microscopic
Cytology
Hematopath
Microscopic
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Scope of Pathology
Pathology
Clinical
Anatomic
Experimental
Chemistry
Urinalysis
Hematology
Serology
Microbiology
Virology
Molecular
T.D.M.
Toxicology
Coagulation
Transf. Med
Point of Care
Flow Cytometry
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Quick Guide to Microscopy

• Unless otherwise stated, pictures in books and
  lecture and hemotoxylin and eosin (HE)
• Proteins and starch stain pink
• Nucleic acids (DNA, RNA) stain blue
• Air, water, sugar and lipids do not stain at all
• Naturally colored materials, black, brown, green

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Quick Guide to Microscopy
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Quick Guide to Microscopy
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Other Colors

• Golden (yellow/brown/green)
• Bile
• Brown
• Hemosiderin, lipofuschin (iron)
• Black
• Carbon
• Melanin

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Special Stains

• PAS ? starch/sugar
• Prussian Blue ? iron
• Oil Red O ? lipids

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Immunohistochemistry

• Produce antibodies to specific molecules, usually
  proteins
• Attach a marker of some kind to the antibody
• Wash a tissue section with the labeled antibody

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Questions?