Big Research Equipment

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Big Research Equipment
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Spray DryerBüchi B-290

• Büchi B-290 spray dryer is an equipment that
  enables transformation of liquid samples
  (solutions, nanosuspensions and suspensions,
  emulsions, etc) to solids. The drying can be
  performed from aqueous or organic solvents in an
  inert atmosphere with organic solvent recycling.
  Product size can be controlled with independent
  setting of liquid feed rate and atomization
  pressure. The machine is customized to be
  suitable for hot-melt technology such as
  spray-congealing. High performance cyclone
  separates the product. The quantity of produced
  solid may vary between few grams and a few
  hundred grams.
• Qualities
• - drying from aqueous and organic solvents
• - allows spray-congealing
• - visual insight into the process
• - automatic nozzle cleaning

Lokacija Department of Pharmaceutical Technology
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Encapsulator Inotech IE 50R

• The production of beads with encapsulator Inotech
  IE 50R is based on the principle that a laminar
  liquied jet is broken into equally sized droplets
  by a superimposed vibration. It enables
  encapsulation of animal and plant cells,
  micro-organisms, enzymes, drugs (liquid or
  solid), flavors and fragrances in beads or
  capsules. A wide range of hydrogel polymers
  are compatible with the Encapsulator Inotech IE
  50R such as alginate, carrageen, cellulose
  sulphate, chitosan, gelatine and pectin.
• single nozzle or concentric nozzle (for
  co-extrusion method) kit with nozzle diameter 100
  1500 µm
• reproducible bead formation (0,15 - 2 mm) with
  narrow bead size distribution
• high cell viability doe to low shear stress
  during bead formation
• short production time (50 3000 beads/s)
• sterile working contitions in an avtoclavable
  reaction vessel (when necessary)
• delivery of the shell/core phase by the
  integrated syringe pump or by air pressure (flow
  rates 70-2500 ml/h)
• appropriate for low viscous liquids
• Location Department of Pharmaceutical Technology

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Freeze dryerBeta 1-8K, Martin Christ

• Freeze drying is the process by which water is
  removed from a frozen material by sublimation. It
  is used for drying delicate, heat-sensitive
  materials of high value or to achieve a porous
  structure.
• Features
• - ice condenser temperature - 54C
• - ice condenser performance max. 6kg/24h
• - drying in round bottom flasks or in vials on
  the thermoregulated shelves

Location Department of Pharmaceutical Technology
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Fluid-bed coater, granulatorBrinox d.o.o., BX
CGD 1

• BX CGD 1 is a novel fluid-bed equipment, which
  can be used for wet granulation, film coating,
  layering and drying procedures. Equipment can be
  successsfuly used also for hot-melt fluid-bed
  procedures. Technological processes can be
  performed in one of two inovative process
  chambers
• Wurster coating chamber with swirl
  generator - process chamber Tornado with
  bottom spraying .
• Advantages - semi/automatic and programmed
  handling - recording of process history -
  ports for FBRM in-line probe usage.
• Batch size 300 g 3000 g

Location Department of Pharmaceutical Technology
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Fluid-bed coater, granulatorGlatt GmbH., GPCG1

• GPCG1 is a fluid-bed equipment, which can be used
  for wet granulation, film coating, layering,
  direct rotor pelletization, powder layering and
  drying procedure. Minor modification of process
  equipment enables hot-melt fluid bed procedures.
  Technological processes can be performed in one
  of three process chambers
• Top spray chamber - Wurster coating
  chamber - rotor insert.
• Advantages
• easy operation and handling - broad range
  of technological procedures
• Batch size 300 g 2000 g

Location Department of Pharmaceutical Technology
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Differential Scanning Calorimeter(DSC) Mettler
Toledo DSC 1, Stare System

• DSC 1 offers a qualitative and quantitativ
  follow and
• measurement of physical and chemical processes
  and
• changes in solids, semisolids and liquids.
• DSC 1 ensures
• Measurement in temperature range between -100
• and 450C.
• 2. Resolution from 0.04 µW( FRS 5) to 0.01 µW
  ( HSS7).
• 3. It might be used either as conventional
  DSC or as
• MT DSCDSC.
• Scope of DSC usage in Pharmacy
• Measurement of 1. (i.e. melting) ali 2. order (
  glassy
• state temperature) phase transitions
• Study of polymorphic transitions and of
  amorphous
• solid state
• Oxidative stability

Location Department of Pharmaceutical
Technology
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FBRM in-line probeMettler Toledo, FBRM C35
FBRM in-line probe is intended for real-time
following of the technological process within
the fluid-bed equipment by enabling us to assess
the evolution of particle size change during
specific phase of technological procedure. Probe
can be used with the BX CGD 1 process equipment
(Brinox). Assessment of the particle size is
performed by measuring of the time of
interruption of laser beam with constant
circumferential speed, which gives us
distribution of particle chord lenghts.
Advantages - measurement
without sample preparation - measurement is
possible in solids volume fractions as high as 70
v/v - pneumatic wiper is cleaning the
optical window of the probe. Measurement range
0.5 mm do 3 mm
Location Department of Pharmaceutical Technology
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Single-punch tableting pressIMA Killian SP300

• Single-punch tableting press SP300 is fully
  instrumented machine and enables measurments of
  upper and lower punch forces, ejection force and
  displacement of the upper punch. It is well
  suited for advanced studies of compressibility,
  as well as analysis of force-displacement curves.
  It is equiped with gravity and forced filling
  shoes. The machine has a wide spectrum of
  applicability from manual production of only a
  few tablets to batch production on
  semi-industrial scale.
• Qualities
• - full instrumentation
• - high flexibility
• Most often used EU-B and EU-D tooling can be
  mounted on the tableting press.

Location Department of Pharmaceutical Technology
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Reciprocating Cylinder - Apparatus III
(BioDis) VanKel, Bio-Dis 3 Testing Station / USP
Apparatus 3, 25-1100

• BioDis apparatus enables observation of drug
  release
• from oral dosage forms with modified release
  delayed,
• prolonged, pulsative. The apparatus is
  accompanied
• by auto-sampler.
• Qualities
• Within the single test 6 different media can be
  used
• mimicking conditions in gastrointestinal tract
  (GIT).
• 2. The influence of different hydrodynamic
  conditions on
• the release from dosage forms can be studied.
• Frequent pharmaceutical usage
• Determination of the media and hydrodynamic
  conditions on the release from different modified
  release dosage forms.
• Optimization of dosage form formulations
• Usage in end control of the products
• Simulation of physiological conditions in GIT.
• etc.

Location Department of Pharmaceutical
Technology
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Modular rheometer Anton Paar, Physica MCR 301

• Rheometer enabled qualitative and quantitative
  determination of rheologic parameters of
  semisolid or fluid systems. It is equipped with
  different module enabling positioning of
  polarised microscope, module for interfacial
  rheological characterization etc.
• Qualities
• Temperature interval from -40 to 200 C
• Modular way of performing measurements
• It can be used as rotational or oscillatory
  rheometer
• Frequent pharmaceutical usage
• Determination of viscosity of fluid and semisolid
  systems in development or in stability control
• Mimicking of different technological procedures
  and
• simultaneously studying the rheological
  parameters
• Study of visco-elastic characteristics of
  hydrogels
• correlation with drug release from matrix
  tablets.
• Study of cross-linking process of different
  polymeric solutions
• etc.

Location Department of Pharmaceutical
Technology
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LC/MS/MS

• LC-MS-MS enables detection and quantification of
  analytes, drugs and thier metabolites in complex
  biologcial samples from in vitro and in vivo
  studies
• a. preclinical studies of solubility, stability,
  permeability, transport and metabolism,
• b. clinical studies,
• c. therapeutic drug monitoring (TDM),
• d. drug metabolite identification,
  chraracterization of degradation product,
  impurities and related substances,
• e. toxicology research, detection and
  quantification of drugs and their degradation
  products in living organisms and in environment.

Location Chair for Biopharmacy and
pharmacokinetics
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Sweetana - Grass diffusion chambers(Physiologic
instruments, USA)

• Sweetana Grass diffusion cells are used for the
  permeability determination of active substances
  through the absorption barriers usually through
  the mucosa of the small intestine.
• With these chambers one can determine the
  permeability coefficients (Papp) of substances
  and
• monitor the electrophysiologic parameters of the
  tissue during the experiment.
• At the Faculty of Pharmacy we have two systems of
  these diffusion cells from Physiologic
  instruments.

Location Chair for Biopharmacy and
pharmacokinetics
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Systems for evaluation of drug dissolution /
release from dosage forms

• Enable drug dissolution and release testing which
  is the most important biopharmaceutical
  evaluation tool in quality control of drug
  delivery systems as well as in development of new
  generic and innovative pharmaceutical products.
• Different pharmacopeial apparatuses might be
  used basket (app. I.), paddle (app. II.) and
  flow through cell (app. IV.) with automatic
  sampling and possible connection to
  spectrophotometer for direct measuring of
  released drug.

Location Chair for Biopharmacy and
pharmacokinetics
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MICROCALORIMETERMicro DSC III, Setaram

• Micro/calorimetry measures the heat changes
  associated with chemical or physical processes.
• It is characterized by unspecificity,
  noninvasivity, sensitivity in µW range, and needs
  no special sample preparation.
• It is used for studying physical processes
  (amorphycity, dissolution, protein denaturation),
  chemical reactions (stability and compatibility
  of drugs and drug formulations), and living
  systems (cells, microorganisms).

Location Chair for Biopharmacy and
pharmacokinetics