Mechanisms of Toxicity

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Mechanisms of Toxicity
To understand ? how a toxicant enters an
organism ? how it interacts with target
molecules ? how the organism deal with the insult
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To provide a rational basis for ? interpreting
descriptive toxicity data ? estimating the
probability that a chemical will cause
harmful effects ? establishing procedures to
prevent or antagonize the toxic effects ?
designing drugs and industrial chemicals that
are less hazardous ? developing pesticides
that are more selectively toxic for their
target organisms
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Example for better understanding of fundamental
physiologic and biochemical process ? Cancer
and carcinogen ? Parkinson