Inflammation p.2

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Inflammation p.2
SYLLABUS RBP(Robbins Basic Pathology)
Chapter Acute and Chronic Inflammation PBD
(Pathologic Basis of Disease) Infectious
Diseases
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Inflammation p.2

• 109 Miliary tuberculosis
• 111 Tuberculous cavity of the lung
• 120 Actinomycosis
• 151 Sarcoidosis
• Enterobiasis (appendix)
• Trichinosis (muscle)
• Nch8025/S Cerebral toxoplasmosis
• 122 Cysticercosis (CNS)

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Miliary tuberculosis (lung)

• millet seed- size (up to 2mm) TB granulomas
• giant Langhans cells
• epithelioid cells
• lymphocytes
• - caseous necrosis

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Miliary tuberculosis
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Miliary tuberculosis
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Miliary tuberculosis
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Tuberculous cavity of the lung
the wall of a cavity internal layer - caseous
necrosis middle layer - components of TB
granulomas outer layer -granulation
tissue -fibrous tissue
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Tuberculous cavity of the lung
please note the micro-slide contains a fragment
of a wall of a big TB cavity, dont search for
small cavities inside that specimen
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Tuberculous cavity of the lung
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Tuberculous cavity of the lung
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Actinomycosis
Actinomyces colonies surrounded by the purulent
inflammtory infiltration
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Actinomycosis
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Actinomycosis
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Sarcoidosis
noncaseating granulomas composed of -
epithelioid cells, - Langhans cells - lymphocytes
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Sarcoidosis
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Sarcoidosis
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Enterobiasis (appendix)

• Tissue
• normal mucosa
• or eosinophilic reaction
• or acute appendicitis
• Worms
• - distinctive lateral alae (thorns in cross
  section) - sections may show eggs within worms
  (eggs may also be seen alone)

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Enterobiasis (appendix)
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Enterobiasis (appendix)
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Trichinosis (muscle)

• Worms
• - encysted coiled roundworms
• Tissue
• muscle cells with inflammation including
  eosinophils and macrophages
• fiber necrosis
• - larval death triggers eosinophilic
  granulomatous inflammation leading to
  calcification
• or
• - a chronic, inactive stage where encysted
  organisms are found in the absence of any
  cellular response.

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Trichinosis (muscle)
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Trichinosis (muscle)
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Cerebral toxoplasmosis

• central foci of necrosis and petechial
  hemorrhages surrounded by inflammatory cells,
  mainly macrophages
• organisms (Toxoplasma gondii) at the periphery of
  the necrotic foci
• marked proliferation of intima in blood vessels
  in the vicinity of the necrosis

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Cerebral toxoplasmosis
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Cerebral toxoplasmosis
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Cerebral toxoplasmosis
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Cysticercosis (CNS)

• Worm
• fluid-filled cyst with eosinophilic laminated
  wall lined by monolayer of rare nuclei
• older lesions fibrotic and calcified
• Tissue
• little inflammation unless ruptured
• (.ppt demonstration only, no slides during the
  microscopy lab)

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Cysticercosis (CNS)
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Cysticercosis (CNS)