Anti epileptic drugs

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Anti epileptic drugs

• by dr antim patidar,
• Dr Prashant,MD.
• Dr Swati Prashant,MD
• drprashantw_at_gmail.com

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epilepsies

• These r a group of disorder of the cns
  characterized by paraxomal cerebal dysrhythmia
  manisfesting as brief episode of loss or
  disturbance of cousciouseness with or without
  body movement
• Epilepsey has a focal origin in the brain

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classification

• 1.barbturatephenobarbiton
• 2.deoxybarbituratesprimidone
• 3.hydantoinphenytion
• 4.iminostibenecarmapazine
• 5.succinimideethosuximide
• 6aliphatic valporic acid
  caboxlic acid

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• 7. benzodiazepinesclonezpam
  diazpam
• 8. phenyltriazinelamotrigene
• 9.cyclic gabaanaloge gabapentine
• 10.newer drug viagabatin,thagabine

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Imp drugs

• Phenytoin and carbmazapine

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1phenytoin

• Mechanism of action this have stablising
  influence on neuron membrane-prevent repititive
  detonation of normal brain cell during
  depolrising shift
• that occurs in epileptic
  patient and consists of a synchronous and usually
  large depolarisation over which action potentials
  is superimposed this is acchived by prolonged
  the in activate stage of voltage sensitive
  neoronal sodium channel

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Genral thing of phenyotin

• 1it is synthesised in1908
• 2poor sedative property
• 3it is not cns depressant
• 4it limit the seizure activity

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Intractions

• Carmazapine and phenytion incraese each other
  metabolism
• valproate displace protien bound phenytion and
  decrease its metabolism

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Adverse effect of phenyotin

• ! gum hypertropy
• 2hirsutism
• 3hypersenstivity reaction
• 4megaloblastic anaemia
• 5osteomalsia
• 6cause hydantoin syndrome
• 7drowziness,mental alteration
• 8fall in blood pressure

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uses

• 1 status epileptus
• 2trigeminal nerualgia
• 3cardiac arrythiamas

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2.carbmazapine
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Imp pionts

• 1chemically related to
• impraime
• 2introduced in 1960 for trigeminal neoralgia
• 3its action resemble phenytion
• 4 same mecanism of action same as phneytion

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Adverse effect

• 1sedation
• 2dizzines
• 3vertigo ,diplopia
• 4ataxia, vomitting
• 5acute intoxication can cause coma
• 6aplastic aneamia
• 7water retantion and hyponatreamia
• 8hepatitis

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uses

• 1trigeminal and related neuralgia
• 2manic deprresion

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interaction

• 1carbamazapine is an enzyme inducer.its
  metabolism is induced by phenobarbitone
• 2by enzyme induction it can reduce efficacy of
  haloperidol