Paul C. Stromberg DVM, PhD

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RESPIRATORY SYSTEM VM 601 PULMONARY
PATHOLOGY CASE STUDIES

• Paul C. Stromberg DVM, PhD
• Diplomate, ACVP
• The Ohio State University

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Case 1 (TVMDL G-861

• History A large herd of swine has recently
  experienced some mortality among animal showing
  acute respiratory signs. Your postmortem
  examination revealed these lungs and no other
  significant lesions.

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Dorsal
Rt Lateral View
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Case 2 (OSU 89-982)

• History A one month old Dorset lamb was found
  dead. Your postmortem examination revealed the
  lungs pictured.

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Lt Lateral View
Anterior-ventral Pattern
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Case 3 (TAMU 84736)

• History A 2 yr old quarter horse that was
  depressed, coughing, appeared somewhat thin and
  had difficulty breathing when ridden. The
  animal had been like this for several weeks and
  when it did not respond to treatment it was
  humanely put down. Necropsy revealed the lungs
  pictured. In addition, there were several masses
  in the wall of the colon as illustrated in the
  2nd photograph

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Dorsal
Dilated subpleural lymphatic
Cranial
Caudal
Heart
Ventral
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Lateral surface
X-sec of lung
Medial surface
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Abscess
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Case 4 (TAMU 84197)

• History A 7 week oild Arabian foal presented in
  severe respiratory distress. The WBC 3500 with
  3300 neutrophils and no lymphocytes.

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Subpleural emphysema
Atelectasis Pneumonia
Normal aerated lobules
Lt Lateral View
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Case 5 (TAMU 82055)

• History A 7 year old Hereford bull was recently
  put on fresh lush rye grass pasture. He was found
  in the pasture depressed, unwilling to drink with
  a swollen throat and marked dyspnea. He died
  enroute to the veterinary hospital at Texas AM
  University. The following 2 photos show the
  postmortem appearance of the lungs.

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Lt lateral view
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Edema Emphysema in interlobular septae
X-sec of caudal lobe
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Case 6 (OSU 89-1919)

• History A 4 yr old Columbiana ewe with exercise
  intolerance, labored respiration (80-100/min) and
  chronic weight loss. Auscultation revealed harsh
  lung sounds most pronounced in the cranioventral
  regions. The animal was euthanized and the lungs
  are visible in the next 2 photos.

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Rib Impressions
Poorly Demarcated A-V Pattern
Lt lateral view
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X-sec of caudal lobe
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Case 7 (OSU-81-1453)

• History A 2 mo old Toggenberg goat with a
  history of ataxia and difficulty breathing. Temp
  was 104.5º and repirations 100/min. Harsh lung
  sounds were auscultated and thoracic radiographs
  showed interstitial densities. Bacterial cultures
  of the sputum were negative.

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Interstitial Pneumonia
Normal Lung
Lt lateral view
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Case 8 (TAMU 81895)

• History This is a 4 yr old Mc DLH cat that has
  not been eating well. He is lethargic, not very
  active and does not want to go outside as often
  as he used to. The owner thinks he has lost
  weight over the last several weeks. PE revealed a
  normal temp but muffled chest sounds and the
  thorax was not as compressible as it should have
  been. The patient was moderately dyspneic in the
  examination room

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Normal Lung
Heart
Pleural Effusion
Lt lateral view
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Case 9 (OSU 87-658)

• History This is a 3 ½ yr old Mc Siamese cat
  presented with fever of 3 wks duration
  nonresponsive to Abx anorexia, depression,
  weakness and hypersalivation. Thoracic
  radiographs revealed increased interstitial
  densities throughout the lung fields but no
  masses. Lab work showed mild renal failure. Mild
  anemia amnd bone marrow hypoplasia. The FeLV test
  was negative. The next 3 photos were taken at
  autopsy.

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Miliary foci of immune-complex
vasculitis
Lt lateral view
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Close-up of caudal lobe
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Miliary Foci of Immune-complex
vasculitis
Kidney
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Case 10 (TAMU 88306)

• History This is a 3 mo old male Chow presented
  for vomiting, diarrhea, wt loss and difficulty
  breathing. The PE revealed a Temp 105º F,
  mucopurulent nasal and lacrimal discharge, tarry
  stools and a rapid but weak pulse. The patient
  was markedly dyspneic and harsh lung sounds were
  auscultated.

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Cranial Lobe
Diaphragm
Middle Lobe
Heart
Lt lateral view
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Case 11 (OSU 87-2827)

• History This is a 12 yr old make Schanuzer that
  presented because of CNS signs and difficulty
  breathing. The neurologic exam revealed boith
  upper and lower motor neuron deficits in the
  limbs and a loss of a menace Rs as well as an
  equivocal Horners Syndrome in the Lt eye.
  Survey radiographs revealed an extensive fluid
  density mass obliterating 90 of the Lt thorax.
  FNA of the pleural fluid contains atypical
  epithelial cells. The next two photos were taken
  at autopsy.

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Lt lateral view
Lt caudal lobe
Lt cranial lobe
Middle lobe
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Hydrocephalus
Metastatic Pulmonary Carcinoma
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Case 12 (OSU 92-1772)

• History This is a 13 yr old Fe DSH cat presented
  for decreased appetite for several wks and
  lethargy for the last 3 days. There is acute
  onset of Rt forelimb paresis. On PE the patient
  exhibited dyspnea and thoracic radiographs showed
  pleural fluid and interstitial densities in the
  Rt caudal lobe. An ECG produced a sinus
  tachycardia. The next 2 photos were taken at
  autopsy.

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Rt Side
Metastatic Renal CA
Rt Lung
Thoracic inlet
Heart
Lt Side
Ventral View
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Normal Kidney
Renal Adenocarcinoma
X-sec of Rt Kidney
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Case 13 (OSU F-1047)

• History This is a 9 yr old FeS Chihuahua
  presented because 1 wk ago the owner noticed the
  patients breathing became noticeable. The
  patient was in poor condition with pronounced
  dyspnea and indistinct lung sounds. The posture
  suggested a ruptured diaphragm. Thoracic
  radiographs revealed marked fluid density
  involving nearly the entire Lt side of the lung
  and vague small interstitial densities in the Rt
  lung. The next 2 photos were taken at autopsy.

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Pulmonary Carcinoma
Transpulmonic Metastases
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Transpulmonic metastases
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Case 14 (OSU 87-2918)

• History This is a 12 mo old make Sprague-Dawley
  rat from the Northwest Career Center. It had been
  eating but losing weight. It was treated with a
  pyrethrin insecticide last week for lice. On
  presentation, the rat was emaciated, weak and
  ataxic with labored respirations. No oculonasal
  discharge was noted but increased lung sounds
  were auscultated.

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Caudal Lobe
Cranial Lobe
Pus-filled ectatic airways
Lt Lateral view
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Case 15 (OSU T-1112)

• History This is one of a litter of 1 wk old
  Hampshire pigs. They were fine for 3 days, then
  became depressed, turned blue and died within
  12 to 24 hrs. The owner has lost 40/72 pigs. The
  photos were taken at autopsy.

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Petecchiae
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Petecchiae
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Case 16 (OSU 92-889)

• History This is Sassette Mann, a 2 ½ yr old Fe
  Himalayan cat presented because of depression and
  difficult breathing. PE revealed a cyanotic
  patient with muffled chest sounds. Thoracic
  radiographs showed extensive pleural fluid. The
  thoracentesis produced cloudy colorless fluid
  with a low cell count (500/µl) in which 90 were
  mature lymphocytes.

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Pleural Effusion
Lt Lung
Lt Lateral View