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Intra uterine growth retardation

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... IUGR Failure of the fetus to chieve the expected weight for a given gestation What is the deference between IUGR & SGA? – PowerPoint PPT presentation

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Title: Intra uterine growth retardation


1
IUGR
Intra Uterine Growth Retardation
2
What is the definition of IUGR?
  • lt 10th centile for age ? include normal fetuses
  • at the lower ends of the growth curve
  • fetuses with IUGR
  • This definition is not helpful clinically
  • lt 5th centile for age ?
  • lt 3rd centile for age ?the most appropriate
  • definition but associated with adverse
  • perinatal outcome

3
What is the deference between IUGR SGA?
  • IUGR ?Failure of the fetus to chieve the expected
    weight for a given gestation

SGA ? lt 10th centile for the population, which
means it is at the lower end of the normal
distribution ie. Constitutionally small but have
reached their full growth potential
4
Small for Gestational Age
  • SGA infants are those with weights below the 10
    percentile for their gestational age

5
The neonatal mortality rate of a SGA infant born
at 38 weeks 1 compared 0.2 in those with AGA
AGA -appropriate for gestational age
6
Incidence
  • 3 -10 of infants are growth restricted

7
25 -60 of infants conventionally diagnosed to
be SGA were in fact AGA when
  • Determinant of birth weight such as maternal
  • Ethnic group
  • Parity
  • Weight
  • Height

8
MORTALITY MORBIDITY
  • Hypothermia
  • Abnormal neurological development
  • Fetal demise
  • Birth asphyxia
  • Meconium aspiration
  • Neonatal hypoglycemia

9
  • ACCELERATED MATURATION

10
Accelerated maturation
  • The fetus resoponses to stressed envirorment by
    adrenal glucocorticoid

Earlier or accelerated maturation
11
SYMMETRICAL VERSUS ASYMMETRICAL GR..
12
Fetal growth has been divided into three phases.
  • cell size
  • fat deposition
  • fetal weight as much as 200 G.r. per week.
  • 1-cellular hyperplasia
  • 2- hyperplasy hypertrophy
  • 3- hypertrophy

13
symmetrical
  • An early insult
  • due to
  • chemical
  • viral
  • aneuploidy
  • Cell size
  • Cell num.

Proportionate reduction in head body
14
Asymmetrical
A late pregnancy insult such as placental
insufficiency would affect cell size.
15
The ratio of brain weight to liver weight over in
the last 12 wk of pregnancy is increased to 5/1
or more
16
Growth pattern may potentially reveal the cause
17
  • In practice accurate identification of
    symmetrical versus asymmetrical fetus has proved
    difficult.

18
Risk factors for FGR
  • Maternal
  • fetal
  • placental and cord abn.

FGR - fetal growth retardation
19
Maternal causes
  • Constitutionally small mother
  • Poor maternal weight gain nutrition
  • Social deprivation

20
  • vascular disease
  • maternal anemia
  • anti phospholipid Ab syn.
  • Extra uterine pregnancy
  • chronic renal disease

21
FETAL CAUSES
  • fetal infections
  • congenital malformations
  • chromosomal abnormalities
  • trisomy 16
  • multiple fetus

22
Placental and cord abnormalities
  • chromic partial placental sep.
  • extensive infarct.
  • Chorioangioma
  • placenta previa

23
ADDITIONAL INSIGHT OF FGR
24
These fetus also had
  • Hypoglycemia
  • hypoinsulinemia
  • glycin/valin
  • hypertriglycemia
  • thrombocytemia

25
Screening and identification of F.G.R
  • Early establishment of G.A
  • Attention to maternal weight gain
  • Measurement of uterine height throughout pregnancy

26
Identification of risk factors
  • A previously GR fetus in women with
  • significant risk factors

Serial sonography
27
Definitive diagnosis usually can not be made
until delivery.
28
MANAGEMENT
  • Once a SGA is suspected , intensive effort should
    be made to determine if GR is present and if so,
    its type and etiology.

29
In the presence of sonographically detectable
anomalies, cordocentesis may be performed for
kariotyping.
30
Prompt delivery is likely to afford the best
outcome for the GR fetus
GR. NEAR TERM
31
In the presence of significant oligohydraminos
most fetus will be delivered if G.A has
reachedgt34 wk.
32
Such often tolerate labor less than AGA and C/S
is indicated for intrapartum fetal compromise.
Unfortunately
33
Importantly
Uncertainly about the diagnosis of GR should
preclude intervention until fetal lung maturity
is assured.
34
GR. REMOTE FROM TERM
before 34 wk Normal Amniotic
volume Normal fetal surveillance
Observation
Sono is repeated at interval 2-3 wk
35
Pregnancy is allowed to continue until fetal
maturity is achieved.
36
At times amniocentesis for assessment of
pulmonary maturity may be helpful in clinical
decision making.
37
There is no specific treatment that will
ameliorate the condition
38
Many clinicians advised a program of modified
rest in the lateral recumbent position in which
c.o.p and placental perfusion is maximized.
39
Optimal management of the preterm GR fetus remain
undefined.
40
Mortality and morbidity in GR fetuses were
determined by GA and birth weight and not by
abnormal fetal testing.
41
Early anti platelet therapy with low dose aspirin
may prevent
  • uretroplacental thrombosis
  • placental infarction
  • idiopathic GR in women with a Hx of recurrent
    sever GR

42
LABOR AND DELIVERY

43
FHR MONITORING

44
  • GR is the result of insufficient
  • placental function
  • c/s
  • A.f cord
  • compression
  • breech presentation

45
Expert assistance
  • In making a successful transition to air
    breathing
  • clear the airway below the vocal cord
  • ventilate the infant as needed

46
The severely GR newborn is susceptible to
  • Hypothermia
  • serious hypoglycemia
  • polycytemia
  • hyper viscosity

47
Prolonged symmetrical FGR is likely to be
followed by slow growth after birth.
Subsequent development of the GR
48
The asymmetrically GR is more likely to catch up
after birth.
49
  • NEUROLOGICAL AND INTELLECTUAL CAPABILITY

50
A LONG TERM FABORABLE OUT COME MAY BE EXPECTED.

51
In a 9-11 year follow up study learning deficit
in almost half of GRF
52
A significant association between fetal growth
restriction and cerebral palsy.
53
The risk of recurrent FGR is increased in women
  • Who have previously had this complication
  • With Hx of FGR
  • A continuing medical complication

54
In the name of Allah, the beneficent. the
merciful
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