Why is a prion so hard to kill

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(No Transcript)
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What is a
Prion?
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Its an infectious protein

• Normal cellular isoform
• Alpha-helices

• Abnormal protein prion
• Beta-sheets

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Its like Dr. Jekyll to Mr. Hyde
3) PrPsc
1) PrPc
2) Alteration
http//nobelprize.org/medicine/laureates/1997/illp
res/novel-inf.html
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PrPc (normal)
PrPsc (prion)
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3) filamentous aggregates damage neural
tissues
2)
convert more PrPc to PrPsc infectious
http//nobelprize.org/medicine/laureates/1997/illp
res/novel-inf.html
http//nobelprize.org/medicine/laureates/1997/illp
res/novel-inf.html
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Prion Diseases

• Vacuolization
• BSE
• Scrapie
• CSE
• Creutzfeld Jacob
• Chronic Wasting
• Disease

www.cowsarecool.com, www.wildlife.utah.com
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Healthy
BSE
www.defra.gov.uk/corporate/vla/science-tse
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Why is a prion so hard to kill?

• Common Infectious Agents
• Bacteria
• Viruses

www.rkm.com.au/BSE/prionimages
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• Prions
• No Nucleic Acids
• Heat/Radiation
• resistant
• No immune
• response
• Any Solutions??

www.ugcs.caltech.edu
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Thank You
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