Jeopardy

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Jeopardy!
Immunology Edition! By Brian Jackson, MS I
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Instructions

• Choose the category and dollar amount. The
  answer will appear on your screen.
• Once youve answered, click anywhere for the
  correct question.
• IMPORTANT Click on the correct question to
  return to the board!
• When youre done with a section, click on the
  link at the bottom of the board to advance.

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Click Here to advance to Double Jeopardy
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• Click here to return to the board.

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Click to advance to Final Jeopardy
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• Click here to return to the board.

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Final Jeopardy!

• Category Immunology People
• Make your wagers now. After you have made your
  wager, click anywhere to continue to the Final
  Jeopardy answer, which you will need to write
  down on your own paper.

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Final Jeopardy!

• Category Immunology People
• He gave his name to the attenuated live polio
  vaccine administered outside of the United
  States.
• (slide will advance automatically after 30
  seconds)

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Final Jeopardy

• The correct question is...
• (click anywhere to see)
• Who is Albert Sabin?

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• Thanks for playing!
• Let me know if you had problems with the program
  or if any of the questions/answers are wrong!
  Comments are always appreciated as well!
• E-mail brianjac_at_gwu.edu
• End Game By Clicking Here

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200 IL Wind

• This cytokine is secreted by APCs and promotes
  secretion of interferon gamma.
• What is IL-12?

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400 IL Wind

• This cytokine promotes immunoglobulin switching
  to IgE.
• What is IL-4?

13
600 IL Wind

• This cytokine promotes eosinophil growth.
• What is IL-5?

14
800 IL Wind

• These two cytokines are responsible for the acute
  phase inflammation response.
• What are IL-1 and IL-6?

15
1000 IL Wind

• This molecule is expressed on stromal cells in
  the thymus and is required for proper T-Cell
  development.
• What is IL-7?

16
200 Be Sensitive

• This type of hypersensitivity reaction is
  mediated by histamine, serotonin, heparin, and
  chemotactic factors.
• What is a Type I reaction?

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400 Be Sensitive

• The hypersensitivity reaction most associated
  with a delay of 24 to 72 hours.
• What is a Type IV reaction?

18
600 Be Sensitive

• Serum sickness is an example of this type of
  hypersensitivity?
• What is a Type III hypersensitivity?

19
800 Be Sensitive

• This is a Type II reaction by a fetus to maternal
  Rh antibody.
• What is erythroblastosis fetalis?

20
1000 Be Sensitive

• This condition is a common sign of a Type I
  hypersensitivity, and is found when cells bind to
  ADCC via F-c receptors for IgG and IgE.
• What is eosinophilia?

21
200 Sharing is Caring

• A positive crossmatch test indicates that this
  type of reaction to an allograft is likely.
• What is a hyperacute reaction?

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400 Sharing is Caring

• An acute rejection requires these two things.
• What are allospecific T-cells and a context of
  disease (or inflammation)?

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600 Sharing is Caring

• This is the most common cause of death among
  transplant patients in the first year after
  transplant.
• What are cardiovascular problems?

24
800 Sharing is Caring

• Cyclosporine is this type of immunosuppressant.
• What is a calcineurin inhibitor?

25
1000 Sharing is Caring

• This organ was the first successful allograft in
  humans.
• What is the kidney?

26
200 Less Than Ideal

• The boy in the bubble had this type of immune
  deficiency.
• What is SCID (Severe Combined Immune Deficiency)?

27
400 Less Than Ideal

• This is an isotype switch defect with an
  increased amount of IgM and a decreased amount of
  other Igs.
• What is X-Linked Hyper-IgM Syndrome?

28
600 Less Than Ideal

• Most immunodeficiency diseases are of this
  general type.
• What are antibody deficencies?

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800 Less Than Ideal

• Examples of deects in this system include
  decreased microbicidal activities in phagocytes,
  defects in NK cells, and complement deficiencies.
• What is the innate immune system?

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1000 Less Than Ideal

• This autosomal recessive disorder involves CD18
  and results in chronic leukocytosis, defective
  wound healing, and recurrent bacterial and fungal
  infections.
• What is Leukocyte Adhesion Deficiency Type 1?

31
200 Ouch! That Hurt!

• Alum is the only approves one of these in humans.
• What is an adjuvant?

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400 Ouch! That Hurt!

• MMR and Varicella zoster are both vaccines of
  this type.
• What are live, attenuated vaccines?

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600 Ouch! That Hurt!

• The IgA antibodies in breastmilk provide this
  type of immunity to an infant.
• What is passive immunity?

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800 Ouch! That Hurt!

• The Hepatitis B vaccine was the first to use this
  technology.
• What is recombinant DNA technology?

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1000 Ouch! That Hurt!

• The WHO hopes that this disease will be
  eliminated by vaccination by the year 2010.
• What is polio?

36
200 Feeling Sick

• This type of pathogen can replicate using RNA or
  DNA.
• What is a virus?

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400 Feeling Sick

• An example of this type of pathogen is Candida
  albicans.
• What is a fungus?

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600 Feeling Sick

• This bacteria causes toxic shock and skin
  abscesses and evades the immune system by means
  of a superantigen.
• What is staphylococcus?

39
800 Feeling Sick

• African Sleeping Sickness is caused by this
  protozoan.
• What is Trypanosome?

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1000 Feeling Sick

• These two main antigens in influenza determine
  the classification of the virus.
• What are hemagglutinin and neuraminidase?

41
400 Barely Tolerated

• The name for sites where antigens are kept
  separate from most lymphocytes to prevent an
  immune response.
• What are immunologically privileged sites?

42
800 Barely Tolerated

• This is the most important genetic factor
  involved in autoimmune disease pathogenesis.
• What is MHC type?

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1200 Barely Tolerated

• Autoimmune Polyendocrinopathy Candidiasis
  Ectodermal Dystrophy involves a genetic defect in
  this gene.
• What is the AIRE gene?

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1600 Barely Tolerated

• This molecule negatively regulates T cell
  activation, and mice without this molecule have a
  lethal autoimmune lymphoproliferative syndrome.
• What is CTLA-4?

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2000 Barely Tolerated

• Lymphocytes that persistently receive a primary
  stimulatory signal without a co-stimulatory
  signal are likely to end up in this inactive
  state.
• What is anergy?

46
400 Innate Talents

• These two complement molecules are
  chemoattractants for additional lymphocytic
  infiltration.
• What are C3a and C5a?

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800 Innate Talents

• CD8CD4- T-cells are associated with this type of
  MHC Complex.
• What is MHC Class 1?

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1200 Innate Talents

• Toll like receptors are an example of receptors
  that bind these molecules.
• What are PAMPs
• (pathogen associated molecular patterns)?

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1600 Innate Talents

• C3b is this type of molecule that enhances
  phagocytosis.
• What is an opsin?

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2000 Innate Talents

• This enzyme is primarily responsible for the
  oxidative burst in macrophages.
• What is NADPH oxidase?

51
400 Organs of the Body

• This immune system organ is made up of red pulp
  and white pulp.
• What is the spleen?

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800 Organs of the Body

• The two immune organs designated as primary.
• What are the bone marrow and the thymus?

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1200 Organs of the Body

• The T-Cell zone within the spleen that surrounds
  certain blood vessels.
• What is the periarteriole lymphoid sheath?

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1600 Organs of the Body

• This lymphatic vessel empties into the left
  subclavian vein or the left jugular vein.
• What is the thoracic duct?

55
2000 Organs of the Body

• Areas of enhanced lymphocytic activity in the
  submucosa of the small intestine are called
  these.
• What are Peyers patches?

56
400 Develop Yourself

• B cell development is completed in this organ.
• What is the bone marrow?

57
800 Develop Yourself

• Most T-cell receptors are made up of these two
  chains.
• What are alpha and beta?

58
1200 Develop Yourself

• Receptor editing (additional chain
  rearrangements) occurs in this type of cell only.
• What are B cells?

59
1600 Develop Yourself

• Immediately prior to lineage commitment as CD4 or
  CD8 cells, T-cells are called this.
• What are double positive T cells?

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2000 Develop Yourself

• The principle that there is only one type of
  receptor per one lymphocyte is called this.
• What is allelic exclusion?

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400 Signal Received

• Found in pentamer form, this is the first type of
  immungloublin produced by B cells.
• What is IgM?

62
800 Signal Received

• Cytotoxic T-cells use this three-lettered
  receptor and its ligand to kill infected cells.
• What is fas?

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1200 Signal Received

• The process of changing from producing IgM to
  producing other immunoglobulins is called this.
• What is isotype switching?

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1600 Signal Received

• Interferon gamma is most associated with this
  type of T cell.
• What is a Th1 cell?

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2000 Signal Received

• Cells with these two CD numbers regulate T cells
  by secreting IL-10 and TGF-beta.
• What are CD4/CD25?

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400 Diagnosis Immunity

• This ABO blood type is the universal donor?
• What is O?

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800 Diagnosis Immunity

• ThoGAM is this type of antibody against Rh
  antigen.
• What is IgG?

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1200 Diagnosis Immunity

• A direct Coombs test detects antibodies bound to
  this type of cell.
• What is a red blood cell/erythrocyte?

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1600 Diagnosis Immunity

• A type IV delayed hypersensitivity reaction is
  used in a skin test for this disease.
• What is Tuberculosis?

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2000 Diagnosis Immunity

• A vaccine for HPV may help to prevent this type
  of cancer.
• What is cervical cancer?

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• The End!