Gu5095'1

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An Automated Approach to the Supply of Samples
for Screening

• Terry Wood
• Pfizer Global Research Development
• Sandwich, UK

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AutomatedLiquidSampleBank

• A secure store for gt2.5 million samples capable
  of delivering daughter plates on demand

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• Project Plan
• The System
• Deliverables
• Future

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The Numbers Challenge
6n
5n
4n
CompoundsTested
3n
2n
n
0
1997
1998
1999
2000
2001
2002
2003
2004
2005
Year
5

• best return oninvestment

• stability

Cheaper
Smarter
Faster

• less time per hit

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SAT - Site Acceptance Test
Milestones
FAT - Factory Acceptance Test

• PINT - Pfizer Integration

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Factory Acceptance Test
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SAT - Site Acceptance Test
Milestones
FAT - Factory Acceptance Test

• PINT - Pfizer Integration

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Site Acceptance Test
Administrator Form Operation Functionality of
all GUI forms that allow the administrator to set
orders. Administrator Transactions Testing of
all sample withdrawal, replacement and
replenishment capabilities described in the
specification. Daughter Plate Orders Ensure the
system delivers all permissible variations of
daughter plate format. Access Procedures The
various elements within the ALSB must be
accessible, but only when the system is in a
safe condition. Replenishment of Demonstration
that all consumable storage modules are
accessible, Consumable Items operable and give
suitable alerts when running low. Alarms and
Recovery Simulation of a wide range of hardware,
software and service from Failure failures, to
demonstrate that the equipment fails safe and the
system is recoverable. Performance
Testing Does the system delivers its output
within the time frames specified.
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SAT - Site Acceptance Test
Milestones
FAT - Factory Acceptance Test

• PINT - Pfizer Integration

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Pfizer Integration Testing
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Legacy Sample Transfer
Plate Based ? Tube Based Tube I.d. Tube
Septum Volume
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The Technical Solution
Cold Store

• 600 plates/24hrs OR
• 6000 single/24hrs

Defrost Station
Customers
Conveyor System

• up to 1000 assay plates/24hrs

LiquidHandlingCells
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Cold Store Gantry Robotics
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Defrost Oven Feeder Robot
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Liquid Handling Cell
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Then ...
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.. Now
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Lessons Learnt

• Marketing
• Buy - in
• Enhancements
• 2o not 1o

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Project buy-in
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