Diabetes Products and Services

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Diabetes Products and Services

• First Draft 03, 2007

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Client Brief

• Summarize the science and scientific developments
  in the diabetes area
• Track patents and emerging technologies for
  solutions to help pre-diabetics and diabetics
• Track products and services currently available
  for diabetics (and pre-diabetics) in the market
• Provide ongoing monitoring and updates for
  developments in the area

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Dolcera Approach
Data collection and mining 1. Scientific
and technological trend data collection 2.
Product categorization 3. Demographic, market
and regional trend data
Scientific knowledge mapping 1. Develop
thorough understanding of the science of the
condition 2. Map current scientific and product
developments on to the knowledge map
Continuous updates
Idea development 1. Test
technical feasibility of ideas 2. Create
implementation strategies 3. Develop ideas and
make them lab-ready 4. Create excitement for new
ideas
Trend analysis and new
idea generation 1. Correlate technical trends
with scientific research results 2.
Identify successful compositions 3. Find the
white spaces based on scientific data and
generate new ideas
4
Dolcera Approach

• The Dolcera team
• Collects and categorizes a large amount of data
  from diverse sources around the world including
  scientific publications, patents, market surveys,
  blogs and images
• Develops a knowledge map of the science and maps
  current developments on to the knowledge map
• Analyzes the trends and identifies white spaces
  and innovation opportunities
• Generates new ideas based on the trends and helps
  implement new ideas

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Data Collection and Mining
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Scientific Data Collection

• Science and medicine sources
• Patent databases worldwide
• SCIRUS
• Google Scholar
• Medline, PubMed, Medscape and other medical
  databases
• Clinical trial data from FDA and commercial
  agencies
• Product formulation and chemical structure
  sources
• Product surveys
• Dietary research
• STN

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Product Categorization

• Products existing in the market will be
  categorized by
• Prescription medication
• Over-the-counter medication
• Foods natural and synthetic
• Food additives
• For each category, the following information will
  be collected
• Medication substance or active ingredient
• Substance action
• Effect of substance on the body
• Delivery process (e.g. devices)

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Social, Market and Regional Trends

• Sociocultural trends
• Consumer trend surveys
• Dietary trends
• Data sources Google, Flickr and Blogs
• Market trends
• Market surveys (AC Nielsen etc.)
• Data from related markets such as pharmaceutical
  industry
• Branded diet plans
• Regional trends
• Identify local products, local traits, and local
  preferences
• Traditional products such as herbal medicines
• Dietary preferences by geography

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Knowledge Map of Science
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Knowledge Map Development

• Overview
• Types of diabetes
• Signs, symptoms, risk factors
• Biochemistry
• Molecular biology
• Metabolic pathways analysis
• Hormonal influences
• Mechanisms of action
• Effect of mature on metabolic pathways and on
  hormones
• Predicted effect of experimental compositions
• Potential white spaces

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Trend Analysis and New Idea Generation
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Example of Trends

• Mechanism of action of currently available
  products
• Increase insulin
• Increase sensitivity to insulin
• Delay absorption of glucose
• Decrease the amount of glucose released from the
  liver
• Slow gastric emptying
• Lower glycemic index

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Whitespace Analysis Example

• Current areas of focus
• Medication
• Diet regulation
• Diet regulation approach
• Increase low glycemic substitute for the existing
  food products and altering the taste and flavor
  to adjust for the same
• Delay glucose absorption by delaying digestion by
  adding more soluble fibers in the diet
• Use low Glycemic Index (GI) substitutes
• Hypothesize methods to decrease the GI of common
  food products

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Idea Implementation Strategy
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Idea Implementation Strategy

• Dolcera team will provide
• List of compositions and food products
• Provide patents and publications to support new
  ideas
• Develop the virtual products that could be
  marketed
• Identify technical and market challenges for the
  virtual products

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Continuous Updates
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Interesting findings

• Drinking Coffee Helps Lower the Chance of Getting
  of Type 2 Diabetes - 12-18-2006
• Eating a Diet High in Fiber Helps Prevent
  Gestational Diabetes - 10-31-2006
• Coffee and Green Tea May Help Prevent Type 2
  Diabetes - 05-24-2006

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Dolcera Approach
Data collection and mining 1. Scientific
and technological trend data collection 2.
Product categorization 3. Demographic, market
and regional trend data
Scientific knowledge mapping 1. Develop
thorough understanding of the science of the
condition 2. Map current scientific and product
developments on to the knowledge map
Continuous updates
Idea development 1. Test
technical feasibility of ideas 2. Create
implementation strategies 3. Develop ideas and
make them lab-ready 4. Create excitement for new
ideas
Trend analysis and new
idea generation 1. Correlate technical trends
with scientific research results 2.
Identify successful compositions 3. Find the
white spaces based on scientific data and
generate new ideas
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Key ingredient of Oreo cookies

• Base cake dough
• High fructose corn syrup
• Dutch cocoa (processed with alkali)
• Pure chocolate liquor
• Wheat flour
• Niacin
• Reduced iron
• Thiamin mononitrate vitamin B1
• Riboflavin vitamin B2
• Folic acid
• Partially hydrogenated soybean oil
• Baking soda
• Cornstarch
• Salt
• Soy lecithin (emulsifier)
• Vanillin - an artificial flavor

?
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Substitutes for High fructose corn syrup

• High fructose corn syrup
• Contains 55 percent sucrose, which requires
  insulin to metabolize.
• It has very high glycemic index

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Substitutes for wheat flour

• Wheat flour
• Powdery substance derived by grinding or mashing
  the whole wheat grain
• White flour contains diabetes-causing
  contaminant alloxan Source

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Mitigation - High fructose corn syrup

• High fructose corn syrup
• Increased consumption of high-fructose corn syrup
  resulting in depletion of chromium in the body,
  which is important in helping glucose pass from
  the bloodstream into the cells

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Mitigation Wheat flour

• Wheat flour
• Ingredients can be combined with regular wheat
  four mitigating its adverse effects by lowering
  glycemic index and slowing digestion

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Products substitute for High fructose corn syrup
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Products substitute for wheat flour