Asthma

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Asthma

• By Emily Ngo

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Asthma Background

• Asthma is a chronic disease that affects up to
  150 million people in the world
• Asthma is an inflammatory disease in the lungs
  that causes constriction in the airways
• Like many other diseases, asthma can be
  controlled but not cured

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Asthma background contd

• Many cells contribute to the inflammation
• The inflammation causes wheezing, coughing, chest
  tightness, and breathlessness

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What happens in the lung?
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Cells that cause inflammation

• lymphocyte
• eosinophil
• mast cell
• epithelial cell
• fibroblast
• macrophage
• neutrophil
• T-lymphocyte

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Cells that cause inflammation
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T-lymphocytes produce cytokines

• Cellular Immunity
• TH1 IL-2, INF-?
• Allergic Inflammation
• TH2 IL-4, IL-5, IL-10, IL-13
• What if there is a balance/imbalance of TH1/TH2?

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Hygiene Hypothesis
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Protect your baby, let your baby play with
animals!
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Relationship of Allergy to Asthma
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Role of Allergy in Development of Asthma
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Treatments

• Asthma Therapy
• Environmental Controls
• Immunotherapy (Allergy Injections)
• Symptomatic Control (bronchodilating agent)
• Disease Modifiers (affect inflammation)

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Environmental Control Measures

• Allergen Avoidance
• House Dust mites
• Grass Pollen
• Indoor Pets
• Feathers and Down

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Allergen Immunotherapy
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