Appalachian Rural Health Institute Diabetes Research Initiative

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Appalachian Rural Health Institute Diabetes
Research Initiative
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ARHI Mission

• Improve the health status and related quality of
  life of underserved rural populations, especially
  those in the Appalachian region
• Umbrella organization for interdisciplinary
  research, education and service

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College of Health and Human Services
Vice President for Research
College of Osteopathic Medicine
ARHI
College of Communication
Edison Biotechnology
College of Fine Arts
Voinovich Center
College of Arts and Sciences
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ARHI Addressing rural health issues

• Health status
• Family health routines
• Innovative diagnostic and treatment options
• Treatment outcomes and effectiveness
• Quality of life measures
• Cultural aspects of health care
• Health policy
• Health psychology
• Access to care
• Health delivery systems
• Health communication
• Health education
• Health literacy

• Gender and health
• Professional preparation of researchers and
  health care providers
• Therapeutic recreation
• Nutrition
• Counseling
• Diabetes
• Heart disease
• Stroke
• Cancer
• Obesity
• Depression
• Communication disorders

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Progress to Date

• Faculty service-research-education network
• Opportunities for faculty members to learn about
  colleagues rural health expertise, confer with
  community representatives, and learn about rural
  health resources
• Database of faculty members with interests in
  rural health

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Progress

• Emphasis on Diabetes Mellitus
• Clinical service and education
• Clinical Diabetes Center
• Athens, Hocking, Vinton Pike County
• Needs assessment
• Interdisciplinary diagnostic and treatment team
• Education to health care professionals, diabetic
  patients, families
• Culturally sensitive health education materials
• Clinical database

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First-Year Plans

• Seek funding
• OU Research Priorities
• Federal Appropriation
• Research project funding
• Training grants

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Progress to Date

• Bicentennial Campaign Gift from the Osteopathic
  Heritage Foundation enabled the recruitment of
  Dr. Frank Schwartz for the development of the
  ARHI Diabetes Center
• Federal Appropriations (2003 and 2004) support
  infrastructure, needs assessment, hiring of
  clinical staff, interdisciplinary screenings,
  some data collection, interdisciplinary retreat
  and meetings
• Appalachian Regional Commission funding to extend
  services supported
• Connections with CHHS HRSA-funded
  Interdisciplinary teaching/learning program in
  diabetes
• Diabetes Center servicing Athens, Hocking,
  Vinton, and Pike Counties
• Mobile van service to outlying areas
• HIPAA and IRB groundwork
• Epidemiological and needs assessment studies
• Concerted work toward sustainability and research
  enhancement

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OU Research Priorities Proposal

• Primary foci

• Research infrastructure
• capitalize on existing investments and resources
• support OUs reputation in diabetes research
• ensure long-term funding success of
  interdisciplinary research in this area
• Research education and research career
  development for undergraduate and graduate
  students, post-doctoral trainees, faculty
  members, and physicians.

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OU Research Priorities Proposal

• Specific strategies

• Address constructively and creatively the
  current barriers
• Implement specific research programs with
  promise for external funding and widespread
  dissemination
• Coordinated interdiciplinary major and seed
  project initiatives
• Projects in basic clinical bench science,
  clinical-behavioral science, and sociocultural
  and healthcare research.

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Direct Participants in the ARHI Diabetes Research
Initiative

• College of Osteopathic Medicine
• Edison Biotechnology Institute
• College of Health and Human Services
• College of Education
• Russ College of Engineering and Technology
  College of Communication
• College of Arts and Sciences
• Innovation Center Interthyr Corporation and
  Diagnostic Hybrids Incorporated.

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College of Health and Human Services
Vice President for Research
College of Osteopathic Medicine
Innovation Center DHI and Interthyr
ARHI Diabetes Research Initiative
Edison Biotechnology
College of Communication
College of Fine Arts
Voinovich Center
College of Arts and Sciences
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Direct Participants in the ARHI Diabetes Research
Initiative

• Beck, Christine CC/Interpersonal Communication
• Berryman, Darlene CHHS/Human and Consumer
  Sciences
• Brooks, Gordon CE/Educational Studies
• Brown, Jim Diagnostic Hybrids Incorporated
• Chen, Xiao EBI,
• Coschigano, Karen EBI
• de Groot, Mary AS/Psychology
• Denham, Sharon CHHS/Nursing
• Goetz, Douglas EBI, RCET/Chemical Engineering
• Gotfried, Robert COM/Family Medicine
• Hallowell, Brooke, CHHS, Hearing, Speech and
  Language Sciences
• Holben, David CHHS/Human and Consumer Sciences
• Inman, Sharon COM/Biomedical Sciences
• Kelder, Bruce EBI
• Kim, Sunny CHHS, AS/Psychology
• Klabunde, Richard COM/Biomedical Sciences
• Kohn, Douglas EBI

• Kohn, Leonard EBI, COM/Biomedical Sciences,
  Interthyr Corporation
• Kopchick, John EBI, COM/Biomedical Sciences
• Kushnick, Michael  CHHS/Recreation and Sport
  Sciences
• Malinski, Tad AS/Chemistry and Biochemistry
• Mehta, Bhavin RCET/Mechanical Engineering
• Nowak, Felicia COM/Biomedical Sciences
• Okada, (Nick) Shigeru EBI, COM
• Rathbun, Ann CHHS/Health Science
• Scholl, David Diagnostic Hybrids Incorporated
• Schwartz, Frank COM, ARHI Diabetes Center
• Seegmiller, Jeff CHHS/Recreation and Sport
  Sciences
• Shubrook, Jay COM/Family Medicine
• Simpson, Christopher COM/Family Medicine
• Wince, Leon COM/Biomedical Sciences
• Zettner, Erika CHHS/Hearing, Speech and Language
  Sciences

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Rationale and Significance

• Need for coordination and focus for
  already-established and productive research
  programs on our campus
• Programs that should be linked have not been
• Previous lack of awareness of complementary
  programs, expertise and facilities

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Specific Strategic Research Project Plans

• Three levels of support
• Basic foundational equipment, supplies,
  facilities, and staff
• Major research project initiatives
• bring together teams of collaborators
• result in major research outcomes (OUs
  reputation, external funding, and bringing
  together most of the key faculty)
• Seed projects
• bring together collaborating teams of researchers
• establish a track record in new or evolving areas
  of diabetes research

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Specific Strategic Research Project Plans

• Basic foundational equipment, supplies,
  facilities, and staff
• Major research project initiatives
• Seed projects

BASIC CLINICAL BENCH SCIENCE
CLINICAL-BEHAVIORAL, SOCIOCULTURAL AND HEALTHCARE
RESEARCH
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Specific Strategic Research Project Plans

• Basic foundational equipment, supplies,
  facilities, and staff
• Major research project initiatives
• Seed projects

Development of new insulin mimetic
drugs Identification of protein targets for
therapeutic approaches in obesity and type 2
diabetes Development of drugs to treat the macro-
and microvascular complications of diabetes
related to inflammation and autoimmunity
BASIC CLINICAL BENCH SCIENCE

• Access to patients in the ARHI Diabetes Center
• Access to biorepository and clinical database

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Specific Strategic Research Project Plans

• Basic foundational equipment, supplies,
  facilities, and staff
• Major research project initiatives
• Seed projects

• John Kopchick growth hormone, obesity/diabetes,
  proteomics/animal models, and targets of therapy
• Xiao Chen insulin mimetic drugs separating
  growth from glucose control
• Doug Goetz leukocyte adhesion/Drug delivery),
• Leonard D. Kohn autoimune and inflammatory
  aspects of Type 1 and 2 diabetes

• Sharon Inman renal complications of diabetes
• Richard Klabunde vascular complications of
  diabetes
• Felicia Nowak insulin signaling,
• Darlene Berryman role of growth hormone in fat
  deposition and lipid metabolism

BASIC CLINICAL BENCH SCIENCE

• Tad Malinski nitric oxide mechanisms in
  autoimmune/inflammatory diseases and wound
  healing

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Specific Strategic Research Project Plans

• Basic foundational equipment, supplies,
  facilities, and staff
• Major research project initiatives
• Seed projects

Pychology Hearing, Speech and Langauge
Sciences Health Communication Physical
Therapy Therapeutic Recreation Gerontology Health
Policy Public Health Epidemiology and
Statistics Nursing
CLINICAL-BEHAVIORAL SCIENCE AND SOCIOCULTURAL
AND HEALTHCARE RESEARCH

• Access to patients in the ARHI Diabetes Center
• Access to clinical database and interdisciplinary
  teams and resources

Health Education
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Specific Strategic Research Project Plans

• Basic foundational equipment, supplies,
  facilities, and staff
• Major research project initiatives
• Seed projects

• Sharon Denham family approaches to diabetes
  care, and cultural aspects of health care and
  access to care in Appalachia

• David Holben food security/insecurity as related
  to diabetes
• Mary de Groot diabetes and depression
• Christina Beck communication interactions
  between health care participants

• Darlene Berryman relationship of excess fat mass
  on the risk of cardiovascular disease and type 2
  diabetes)
• Brooke Hallowell changes in cognitive,
  linguistic and hearing functions with varying
  glucose levels in diabetes
• Ann Rathbun health literacy and its impact on
  prevention, care, and access to care for persons
  with diabetes

CLINICAL-BEHAVIORAL SCIENCE AND SOCIOCULTURAL
AND HEALTHCARE RESEARCH

• Christopher Simpson physician-patient
  interactions and health care access

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Direct and Overlapping Connections through an
Enhanced Research Focus on Diabetes

• Enhanced research, educational and clinical
  collaborations in numerous additional areas,
  including
• Conditions inherent in the study of diabetes,
  such as obesity and the metabolic syndrome
• Conditions presenting as complications of
  diabetes, such as atherosclerosis, stroke,
  cardiovascular disease, and macro- and
  microvascular sequellae
• Associated diseases known to have a higher
  prevalence in persons with diabetes, including
  cancer and other endocrine autoimmune diseases

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ARHI Diabetes Initiative Advisory Board

• Jack Brose, DO (Dean of COM),
• Brooke Hallowell, PhD (CHHS Associate Dean of
  Research and Sponsored Programs, Co-Director of
  ARHI, and Research Coordinator for this
  Initiative).
• Leonard Kohn, MD (J.O. Watson Endowed Research
  Chair in diabetes research, Founder of Interthyr
  Corporation, and Distinguished Senior Research
  Scientist in Biomedical Sciences and EBI, and
  Basic Science Advisor for this Initiative)
• Gary Neiman, PhD (Dean of CHSS)
• Frank Schwartz, MD (Endocrinologist, Director of
  ARHI Diabetes Center, and Clinical Research
  Director for this Initiative)
• Christopher Simpson, DO (Department Chair of
  Family Medicine, Director of ARHI, and Education
  Coordinator for this Initiative)
• David Wight, PhD (EBI Director)

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Basic foundational equipment, supplies,
facilities, and staff

• Maintenenance of the ARHI Diabetes Center
  Biorepository and Database
• Biorepository technician
• Clerical staff person
• Supplies
• Tenure-track junior faculty member in
  Endocrinology to teach in COM, assist in the
  Diabetes Center, and participate in the basic and
  clinical research programs

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Basic foundational equipment, supplies,
facilities, and staff

• Tenure-track junior faculty member in
  Epidemiology and Biostatistics to participate in
  statistical consultation, contribute to new
  general education courses, and content in Health
  Administration and Public Health
• Tenure-track junior faculty member in Biomedical
  Engineering to support research and
  teaching/learning opportunities and the
  development of a new biological engineering
  program

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Basic foundational equipment, supplies,
facilities, and staff

• Extension of research career development and
  grantwriting support through shared Research
  Coordinator and Grants and Contracts Manager
• Diabetes research technician cross-trained to
  support major research initiatives directed by
  basic clinical science investigators
• Post-doctoral researcher to be appointed
  competitively each year

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Basic foundational equipment, supplies,
facilities, and staff

• ARHI-Diabetes Undergraduate Research Internship
• ARHI-Diabetes Graduate Research Fellowship
  programs
• Research training for physician Diabetology
  Fellows
• Course on Interdisciplinary Clinical Research in
  Diabetes
• Annual OU Diabetes Research Symposium
• Annual OU Diabetes Research Retreat

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Whats next?

• Funding possibility 4,066,135
• Current status of review process
• We can proceed with much of what we propose
  regardless of the outcome of the OU RP process

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Your important role

• Enrich the network
• Share your expertise
• Brainstorm with others on external funding and
  research project possibilities
• Communicate through the network
  (lockharl_at_ohio.ed)
• Stay in touch