IFR FORWARD OPEN DAY 2006

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IFR FORWARDOPEN DAY 2006

• 7 September 2006

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IFR Science Skills Base
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Gut Biology
Understanding gut health and function
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Gut Biology
Nutrition, Diet Health
How our diet influences our long-term health
A volunteers life
Human Nutrition Unit
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Obesity Trends Among U.S. AdultsBRFSS, 1985
Source Behavioral Risk Factor Surveillance
System, CDC
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Obesity Trends Among U.S. AdultsBRFSS, 1986
Source Behavioral Risk Factor Surveillance
System, CDC
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Obesity Trends Among U.S. AdultsBRFSS, 1987
Source Behavioral Risk Factor Surveillance
System, CDC
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Obesity Trends Among U.S. AdultsBRFSS, 1988
Source Behavioral Risk Factor Surveillance
System, CDC
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Obesity Trends Among U.S. AdultsBRFSS, 1989
Source Behavioral Risk Factor Surveillance
System, CDC
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Obesity Trends Among U.S. AdultsBRFSS, 1990
Source Behavioral Risk Factor Surveillance
System, CDC
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Obesity Trends Among U.S. AdultsBRFSS, 1991
Source Behavioral Risk Factor Surveillance
System, CDC
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Obesity Trends Among U.S. AdultsBRFSS, 1992
Source Behavioral Risk Factor Surveillance
System, CDC
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Obesity Trends Among U.S. AdultsBRFSS, 1993
Source Behavioral Risk Factor Surveillance
System, CDC
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Obesity Trends Among U.S. AdultsBRFSS, 1994
Source Behavioral Risk Factor Surveillance
System, CDC
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Obesity Trends Among U.S. AdultsBRFSS, 1995
Source Behavioral Risk Factor Surveillance
System, CDC
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Obesity Trends Among U.S. AdultsBRFSS, 1996
Source Behavioral Risk Factor Surveillance
System, CDC
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Obesity Trends Among U.S. AdultsBRFSS, 1997
Source Behavioral Risk Factor Surveillance
System, CDC
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Obesity Trends Among U.S. AdultsBRFSS, 1998
Source Behavioral Risk Factor Surveillance
System, CDC
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Obesity Trends Among U.S. AdultsBRFSS, 1999
Source Behavioral Risk Factor Surveillance
System, CDC
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Obesity Trends Among U.S. AdultsBRFSS, 2000
Source Behavioral Risk Factor Surveillance
System, CDC
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Obesity Trends Among U.S. AdultsBRFSS, 2001
Source Behavioral Risk Factor Surveillance
System, CDC
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Obesity Trends Among U.S. AdultsBRFSS, 2002
Source Behavioral Risk Factor Surveillance
System, CDC
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Gut Biology
Nutrition, Diet Health
Molecular Microbiology
Understanding and controlling bacterial foodborne
pathogens
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Gut Biology
Nutrition, Diet Health
Food Biophysics
Molecular Microbiology
Maintaining food quality with a healthy diet
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IFR Science Skills Base
Gut
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New Research Leaders

• Systems Biology
• Gut Biology
• Molecular Immunology
• Molecular nutrition

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IFR Technology Skills Base

• omics
• Transcriptomics microarrays
• Proteomics
• Metabolomics
• Imaging
• TEM, SEM, Light Microscopy
• Nmr
• Atomic Force Microscopy

Oh Me, Oh my omics and Wheres Wally 3
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Exploitation Platforms

• Sustainability of food chain Keith Waldron
• Magnetic Resonance Imaging Brian Hills
• Model Gut Martin Wickham
• National Collection of Yeast Cultures Ian
  Roberts
• Food Databanks Paul Finglas
• Microbial Ecology Tim Brocklehurst

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• Facilitates a knowledge-based industry
• Helps develops relationships between IFR and its
  industry stakeholders that bring mutual benefits
• Cost-effective knowledge-sharing
• www.foodandhealthnetwork.com - promoting an
  environment where food Industry professionals can
  network with research scientists

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• Activities
• Regular Cluster meetings on relevant topics
• Cross-cluster meetings on areas of more general
  interest at locations convenient to industry
  (North and South). Proposed topics now available
  on FHN stand
• FHN Direct 11 consultations on confidential
  basis at IFR or on-site

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• The Clusters their Leaders
• Allergy Clare Mills
• Co-product exploitation Keith Waldron
• Food Structure Nutrition Pete Wilde
• Pathways to personalised nutrition Siân Astley
• Predictive Microbiology Risk Analysis
• Jòzsef Baranyi
• Quality throughout Shelf-Life Reg Wilson

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Food Health Network Direct

• One-to-one collaboration with the food industry
• Your issues our complementary skills

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Norwich Research Park

• PBL
• Licensing
• Patent Protection
• Market Research

PBL
UEA Triangle

• UEA
• Institute of Health
• Medical School
• Computer Science
• Chemistry Pharmacy
• Biology

JIC
IFR
Hospital NNUH
UEA Main Campus

• NNUH
• Clinicians within IFR
• Histo-pathology
• Tissue Bank
• Numerous depts

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European Agenda

• Member of Initiative Group (with Wageningen and
  Unilever) for development of a vision document
  for a
• European Technology Platform Food for Life
• Food and Health
• Food Quality and Manufacturing
• Consumer and the integrated food chain

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IFR Technology Skills Base

• omics
• Transcriptomics microarrays
• Proteomics
• Metabolomics
• Imaging
• TEM, SEM, Light Microscopy
• Nmr
• Atomic Force Microscopy

• Bioinformatics
• Statistics
• Modelling
• High-throughput analysis
• Human Nutrition Unit
• National Collection of Yeast Cultures

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Strategic Plan Vision and Mission

• Vision
• to be a world-leading contributor to harnessing
  food for health and controlling food-related
  disease

• Mission
• Undertake international quality scientific
  research relevant to food and human health
• Work in partnership with others to provide
  underpinning science for consumers, policy
  makers, the food industry and academia

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IFR

• The Institute of Food Research (IFR) is a
  not-for-profit company with charitable status
• Sponsored by the Biotechnology Biological
  Sciences Research Council

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Strategic Plan Objectives

• Gastrointestinal Tract Biology Understanding gut
  health and function
• Nutrition, Diet and Health Understanding how our
  diet influences our long-term health
• Food Innovation Maintaining food quality with a
  healthy diet
• Food Safety Understanding and controlling
  bacterial foodborne pathogens

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IFR

• Turnover
• 15m pa

9.1

• 190 scientific staff, 18 PhD students
• Admin Support joint with JIC

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Outputs

• High-quality science base
• Research papers
• Underpinning evidence for policy especially for
  Government (FSA, Defra, DH)
• Influence on policy
• Knowledge Transfer especially for industry
• Collaboration
• Licensing, spin-outs etc

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Basic Science
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Strategic Relevance
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FSA
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Influence on policy

• The institute has made important contributions
  to the development of UK policy on e.g.
• Dietary fibre (throughout the 1990s)
• Fruits and vegetables (development of 5-a-day
  advice - 1998)
• n-3 fatty acid consumption (from fish - 1999)
• Mineral nutrition (1990s and 2000s)
• Colonic health (late 1990s)
• Shelf-life of chilled foods (2000s)

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Delivery

• Programmes
• Partnerships
• Exploitation Platforms

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Programmes

• Shortform title Prog Leader
• GI tract biology and health Ian Johnson
• Commensals microflora Mike Gasson
• Phytochemicals Health Richard Mithen
• Micronutrients Sue F-Tait
• Personalised (mol) Nutrition to be appointed
• Structuring foods for health Clare Mills
• Pathogens mol microbiol Jay Hinton
• Pathogens Phys Pred Ecol Mike Peck

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Internal Partnerships

• Bioinformatics and statistics Kate Kemsley
• Technologies for Systems Biology
• Transcriptomics Tony Michael
• Proteomics
• Metabolomics
• Risk Consumer Science Nigel Lambert
• Imaging Vic Morris
• Support Units
• HNU, North Site?UEA

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Research Collaborations

• Our scientific research collaboration stretches
  across the world through informal and formal
  partnerships. Examples

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Molecular Microbiology
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Nutrition, Diet and Health
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Obesity

• Body Mass Index (BMI) a measure of an adults
  weight in relation to height, specifically the
  adults weight in kilograms divided by the square
  of his or her height in meters.
• Obesity having a very high amount of body fat in
  relation to lean body mass, or Body Mass Index
  (BMI) of 30 or higher.
• Overweight a BMI between 25 and 30.

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Case 2 Obesity
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Gut Biology
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Norwich Research Park

• PBL
• Licensing
• Patent Protection
• Market Research

PBL
UEA Triangle

• UEA
• Institute of Health
• Medical School
• Computer Science
• Chemistry Pharmacy
• Biology

JIC
IFR
Hospital NNUH
UEA Main Campus
Sainsbury Laboratory

• NNUH
• Clinicians within IFR
• Histo-pathology
• Tissue Bank
• Numerous depts

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IFR Skills Base
Gut Biology
Nutrition, Diet Health
Molecular Microbiology
Food Biophysics
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Functional Genomics / Systems Biology
Genome Sequences Pathogens Salmonella
enterica Campylobacter jejuni Clostridium
botulinum Commensals Lactococcus
lactis Lactobacillus johnsonii Bifidobacterium
breve
L. Lactis MG1363
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Bacterial Microarrays _at_ IFR 2006

• SALSA 4 Salmonella serovars 5600 genes
• ShE. Coli 6500 genes
• E. coli O157 Shigella flexneri 150 EPEC/
  ETEC virulence genes
• Campylobacter jejuni
• 1800 genes, plus plasmids
• Clostridium botulinum
• 3456 genes
• Lactococcus lactis
• 2587 genes
• Coming soon
• Bifidobacterium breve
• Lactobacillus johnsonii

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Salmonella Compendium Database 1.0
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SPI1 caught napping?

• Hierarchical clustering of EnviCom
• SPI1 genes cluster with 5 nap genes
• A co-regulatory mechanism?
• Do the nap genes play a role in invasion?

SPI1
napFDHBC
SPI1
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IFR Skills Base