Increased Level of Highly Sensitive CReactive Protein in Retinal Vein Occlusion and Nonarteritic Isc

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Increased Level of Highly Sensitive C-Reactive
Protein in Retinal Vein Occlusion and
Nonarteritic Ischemic Optic Neuropathy

• H.B. Harold Lee, MD
• Jose S. Pulido, MD MS
• Colin A McCannel, MD
• ASCRS, March 17-22

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Purpose and Design

• Purpose To determine the level of highly
  sensitive C-reactive protein (hs-CRP) in patients
  with retinal vein occlusion (RVO) and
  non-arteritic ischemic optic neuropathy (AION).
• Design Consecutive case series

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Methods

• Eleven patients (6 male and 5 female) that
  presented during a 5 week period with either RVO
  or AION underwent measurement of hs-CRP. Six
  patients had a branch retinal vein occlusion,
  four had a central retinal vein occlusion, and
  two had both anterior ischemic optic neuropathy
  and either a branch or central retinal vein
  occlusion.

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Results

• The levels of hs-CRP ranged from 1.0 to 18.0
  mg/L (mean of 6.5 mg/L with a standard deviation
  of 6.1). Standardized levels for hs-CRP are 0 to
  1.0 mg/L for low risk of inflammation, 1.0 to 3.0
  mg/L for average risk, and gt3.0 mg/L for high
  risk.

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Patients
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Conclusions

• Understanding aggressive treatment of
  cardiovascular disease and its inflammatory
  component may result in reduction of hs-CRP and a
  decrease in risk for the development of vascular
  disease.
• The new role of hs-CRP is important for an
  ophthalmologist because of its part in vascular
  disease. Evaluation of hs-CRP levels may help
  identify patients at risk for vascular disease
  and initiate treatment of the inflammatory
  component of these diseases.