The Coagulation Zoo Part 1

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The Coagulation Zoo Part 1
HORSE Equine collagen is used for Von Willebrand
Factor (VWF) Collagen Binding Assay
HUMAN Brain and placenta are sources for Tissue
Factor used in Prothrombin Time (PT) reagents
COW Bovine lung is source for heparin Brain and
lung are sources for Tissue Factor used in PT
reagents
PIG Porcine intestinal mucosa is source for
heparin Factor VIII has been used to treat
patients with FVIII inhibitors
RABBIT Brain and lung are sources for Tissue
Factor used in PT reagents
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The Coagulation Zoo Part 2
Hirudo medicinalis Hirudin (from salivary
glands) is a direct inhibitor of Thrombin
Echis carinatus (African Saw-scaled Viper)
Tirofiban (Aggrastat) is a disintegrin that
inhibits platelet GPIIb/IIIa receptor also used
in Ecarin Clotting Time test
Agkistrodon rhodostoma (Malayan Pit Viper)
Ancrod digests Aa chain of Fibrinogen producing a
molecule with increased susceptibility to lysis
by Plasmin leading to hypofibrinogenemia
Vipera russellii (East Indian Viper-Cobra manil)
venom directly activates Factor X used in dilute
Russell Viper Venom (dRVV) test
ß - hemolytic streptococci Streptokinase is an
activator of Plasminogen