Christian Burks

1
Fish Genomics in Canada

• Christian Burks
• CBurks_at_OntarioGenomics.ca
• www.OntarioGenomics.ca

2
Fish Genomics in Canada

• Ontario Genomics Institute
• Fish Genomics

3
From Central Dogma to Discovery Platforms
holistic, high-throughput systematic approaches
to building resources
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Ontario Genomics Institute (OGI)

• Building a globally-competitive life sciences
  industry in Ontario
• Fund top tier science technology
• Fund best organized projects
• Facilitate precipitate commercialization
• Focus on societal outcomes
• 50 co-funding requirement (international
  collaborations count)

5
OGI RD Project Portfolio

• 320M portfolio of 24 projects to date led by
  Ontario scientists
• 3M - 30M per program (10M average)
• human health, tech development, agriculture,
  forestry environment
• examine associated impact ethics, environment,
  economic, legal social
• 2 platform projects proteomics (PTCF) and
  genomics (GRC)

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International Programs

• Structural Genomics Consortium
• Led by Aled Edwards _at_ University of Toronto
• Detailed three-dimensional structure of 350
  proteins (starting point for drug discovery)
• 115M
• ICI work being done in and funded by Canada,
  United Kingdom Sweden
• Segmented DNA Duplications
• Ontario work led by Steve Scherer _at_ Hospital for
  Sick Children
• Duplicated DNA in neurodevelopmental-diseases
  and evolution
• 6M
• work being done in and funded by Canada Spain
  (Genoma España)
• International Regulome Consortium (in planning
  development)
• Led by Michael Rudnicki _at_ Ottawa Health
  Research Institute
• map the mechanisms and networks that control
  the genes that comprise the genome
• to be determined . ultimately, 50M -
  100M program development funds from MEDT
• potential ICI Canada, Australia, France,
  Germany, Italy, Netherlands, Singapore, UK USA

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Fish Genomics in Canada

• Ontario Genomics Institute
• Fish Genomics

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Atlantic Salmon Genomics

• Leads Willie Davidson (Simon Fraser U.)
• Ben Koop (U. Victoria)
• Collaboration Bjorn Hoyheim (Norwegian School of
  Veterinary Science)
• Sharing BAC libraries, ESTs, QTL markers, etc.
• Funding 6M (Genome Canada others) 6M
  (Norway)
• Focus Integrate genetic and physical maps
• Identify genes ( gt 16,000) ? linked to
  disease, stress, growth, and development ?
  use variation for identifying conservation units
• Characterize gene regions relevant to
  aquaculture ? immune system genes ?
  stress and disease
• ? sex determination

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Aquaculture Disease Management

• Lead Laura Brown (NRC Institute for Marine
  Biosciences)
• Consortium ? NRC Institute for Marine
  Biosciences, Halifax
• ? NRC Institute for Biological Sciences,
  Ottawa
• ? Dalhousie University, Department of
  Microbiology
• ? Fisheries and Oceans Canada
• Funding 9M (NRCs Genomics and Health
  Initiative others)
• Focus genomics, proteomics metabolomics
• ? to produce vaccines vaccine delivery
  systems
• for Aeromonas salmonicida
• ? to understand the effects of husbandry
  stressors
• on vaccine efficacy

10
Flatfish Genomics

• Leads Susan Douglas (NRC IMB, Canada)
• Joan Cerda Luque (IRTA, Spain)
• Consortium Genome Canada (NRC IMB, Dept of
  Fisheries and Oceans, Scotian Halibut Ltd.)
• Genoma España (Nine academic government
• organizations, Oryzon Genomics)
• Funding 5M (2M from Genome Canada)
• Focus Large-scale genomics and proteomics
  approaches
• to enhance the commercial culture of Atlantic
• Halibut and Senegal Sole.
• ? gene sequencing
• ? expression arrays
• ? genetic linkage maps

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Zebrafish Functional Genomics

• Lead Marc Ekker (CAREG, U. Ottawa)
• Funding CIHR, NSERC
• Focus environment --
• ? impact of environmental stressors on
• genome expressivity
• ? identification of novel biomarkers
• human health --
• ? screens for novel mutations
• ? model Parkinsons disease, heart
  arrhythmia
• sexual differentiation
• ? reporter transgenic zebrafish for
  functional
• assays

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Ontario Genomics Institute

• Christian Burks
• CBurks_at_OntarioGenomics.ca
• www.OntarioGenomics.ca