The balancing act' Redox poise and signalling

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The balancing act. Redox poise and
signalling The Drummond lecture Queen Mary,
University of London http//plantcell.lu.se/bala
ncing
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New Zealand Dr Muriel Emma Bell (CBE) was awarded
the William Gibson Research Scholarship for
Medical Women of the British Empire by the Royal
Society of Medicine. This enabled her to work for
three years with Professor Jack Drummond at
University College, London.
Australia Australian Academy of Science. Victor
Martin Trikojus 1902-1985 went to London, where
Trik spent some months with Professor Jack
Drummond at University College. This gave him the
opportunity of extending his contacts with
endocrinologists, as well as getting to know one
of the great figures in British nutrition.
Wales. David Hughes, the first Professor and
Head of Department of Microbiology at Cardiff
(1964-1982) brought back happy memories of the
golden past. He also brought the house down with
his story of Sir Jack Drummond who coated a
haddock with yellow phosphorus to demonstrate to
medical students, its "bioluminescence". Trouble
was his hands glowed in the darkened lecture
theatre more strongly than the fish!
David Lloyd, Biotype. The Newsletter of the
School of Pure Applied Biology, University of
Wales Cardiff. Volume 6 Issue 2 April 1996
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Acknowledgements
Lund University Plant Cell Biology-Plant
Biochemistry
http//plantcell.lu.se Thomas
Pfannschmidt (Now University of Jena,
Germany) Dalibor Stys (Now S. Bohemia University,
Czech Republic) Anders Nilsson (Now Bruker
Spectroscopy, Lund) Sylvan Dubé (Now Laval
University, Canada) Paul Davison (Now Sheffield
University, U.K.) H. Louise Race (Now Aylesbury,
U.K.) Jens Forsberg Jörgen Ström Boaz
Laadan Carol Allen Collaborations Torbjörn
Drakenberg, Sture Forsén (Lund Physical Chemistry
2) Gerhard Link (University of Bochum, Germany)
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Light 1
Light 2
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The balancing act1.

• Transients, enhancement, and redox poise of
  cyclic electron flow.
• Rates and activities of components.

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Myers, J. (1971) Annu. Rev.Plant Physiol. 22,
289-312
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Hill, R. (1965) Essays Biochem. 1, 121-151
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Park, R. B. and Sane, P.V. (1971) Annu. Rev.
Plant Physiol.22, 395-430
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Photosynthesis
Forsberg, J. (2002) PhD thesis. Lund University
Blankenship, R. E. (2002) Molecular Mechanisms of
Photosynthesis. Blackwell Science, Oxford
Heathcote, P. et el. (2002) Trends Biochem. Sci.
27, 79-87
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Pfannschmidt, T. et al. (1999) IUBMB Life 48,
271-276
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The balancing act2.

• Protein phosphorylation and state transitions.
  Post-translational modification of the structure
  and function of proteins you already have.

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Allen, J. F. (1992) BBA 1098, 275-225 . Adapted
from Allen, J.F. et al. (1981) Nature 291, 25-29
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Dubé, S., Davison, P.A. and Allen, J. F.
(unpublished)
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State 1
State 2
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State 1
State 2
Allen, J. F. and Forsberg, J. (2001) Trends Plant
Sci.6, 317-326
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Nilsson, A. et al. (1997) JBC 272, 18350-18357
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The balancing act3.

• Redox control of gene expression. Changing
  transcription and the stoichiometry of complexes.

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Allen, J. F. (1992) BBA 1098, 275-225
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Pfannschmidt, T. et al. (1999) IUBMB Life 48,
271-276
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The balancing act4.

• Redox signalling and evolution.
• Why chloroplasts (and mitochondria) have genomes

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Race, H. L., Herrmann, R. G. and Martin, W.
(1999) Trends Genet. 15, 364-370
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Allen, J. F. (1993) J. Theor. Biol. 165, 609-631
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Chloroplast genes and gene products
Allen, J. F. (1993) J. Theor. Biol. 165, 609-631
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The balancing act. Redox poise and signalling

• Transients, enhancement, and redox poise of
  cyclic electron flow.
• Protein phosphorylation and state transitions.
• Redox control of gene expression.
• Redox signalling and evolution.

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Quinone pools Why is redox poise maintained,
apparently by every possible means?

• Efficiency. Example - state transitions in
  oxygenic photosynthesis.
• Safety - minimizing single electron transfers to
  oxygen.

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The balancing actPostscript.

• The Q-cycle, quinone and superoxide anion
  radicals. The mitochondrial theory of ageing,
  and the evolution of sex.

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Allen, J. F. (1993) J. Theor. Biol. 165, 609-631
Mitochondrial genes and gene products
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Crofts, A.R., et al. (1998) In Proceedings of
the IXth. International Symposium on Phototrophic
Prokaryotes, Vienna, (Peschek G., ed.)
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ALLEN, J F (1996) J. Theor. Biol. 180, 135-140
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Thank you for your attention
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The balancing act. Redox poise and
signalling The Drummond lecture Queen Mary,
University of London http//plantcell.lu.se/bala
ncing
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ALLEN, J F (1996) J. Theor. Biol. 180, 135-140