Effects in pig breeding

1

• Effects in pig breeding

2

• ASCOGEN is composed of natural substances and is
  used in animal breeding and fattening
• The following metabolites are used
•      Purified RNA
•      Purified nucleotides
•      Organic acids
•     Inactived yeast as carrier
•  
• These are all substances, which are naturally
  occurring in all living organisms. Therefore they
  leave no residues meat.

3

• The following cells is positively influenced
• Cells of the intestinal flora
• Gastrointestinal cells
• Immuno-competent cells
• Liver cells
• Glandular cells

4

• EFFECTS ON THE PERFORMANCE OF SOWS

5

• TRIAL AT THE TIGER MOUNTAIN FARM
•  
•   
• TAIWAN
•  
• December 2001 May 2002

6

• Results at day 56
•  
• Sows
• Control Group 180 sows randomly selected
•  
• Test Group 230 sows randomly selected
• ASCOGEN from 90 days before farrowing to
  weaning
• Inclusion rate is 500 grams per metric ton of
  sow feed.
•  
• Piglets
• Control Group 224 heads weaned pigs randomly
  selected (1,441 heads)
•  
• Test Group 210 heads weaned pigs randomly
  selected (1,979 heads)
• ASCOGEN was fed to the weaned pigs until 56
  days age
• Inclusion rate is 1 kg per metric ton of
  piglets feed.
• Problem PMWS infection high mortality of
  piglets

7

• Results at day 56
•  
• Sow performance
•  
• Average piglets born Total piglets born
• per sow per sow
• Control group 8.14 1441
• Test group 8.79 1979
• Piglet performance at day 56
• Piglets (heads) Piglets died Mortality
  Average body
• survival (Heads) () weight
  (kg/head)
• Control 191 (of 224) 33 14.74
  17.50
• Test 188 (of 210) 22 10.48 19.80

8

• Total survival
•  
• Control Group 78.2
• Test (ASCOGEN) Group 80.0
• Improvement 1.8
•  
•  
• Weight gain from weaning at 4 weeks (28 days) to
  56 days
•  
• Control Group 10.85 kg
• Test (ASCOGEN) Group 13.66 kg
• Improvement 2.81 kg

9

• Role of glutamine and nucleotides on growth,
  immune response and FMD antibody titres of weaned
  pigs
• Dr. Yu et al
• Animal Technology Institute Taiwan
• 2002

10

• Animals 48 weaned pigs (4 weeks old) (Landrace
  x Yorkshire x Duroc crossbred)
• Groups 3 x 16 piglets
• Treatments Control group Normal starter diet
• Trial group 1 Starter diet 10g/kg Glutamine
  500 ppm ASCOGEN
• Trial group 2 Starter diet 10g/kg Glutamine
  1000 ppm ASCOGEN
• Analysis Daily weight gain
• Food intake
• Villous height
• Immune reaction

11

• Effect on growth
• Control Trial group 1 Trial group 2
• Daily weight gain (g)
• weeks 0-4 270 270 305
• weeks 4-8 646 651 708
• weeks 0-8 437 444 497
• Food intake (kg/day)
• weeks 0-4 0.56 0.48 0.55
• weeks 4-8 1.32 1.42 1.57
• weeks 0-8 0.89 0.89 0.93
• Villous height (µm)
• Duodenum 185 207 210
• Jejunum 197 205 243

12

• Effect on immunological parameter
• Control Trial group 1 Trial group 2
• Immunglobulin - G (IgG mg/ml)
• Pre-LPS 27.3 32.5 30.0
• 1 h post LPS 27.9 29.5
  34.1
• 2 h post LPS 29.8 40.4
  47.9
• 8 h post LPS 41.9 58.0
  67.4
• Immunglobulin - A (IgA mg/ml)
• Pre- LPS 877 904 929
• 1 h post LPS 903 857 908
• 2 h post LPS 828 855 971
• 8 h post LPS 979 1040 1196
• FMD neutralizing antibody titres
• Pre-vaccine (12 weeks) 3.7 3.9
  3.5
• Post-vaccine ( 3 weeks) 29 49
  111

13

• TRIAL in France on SOWS and PIGLETS
• 2001
• Number of animals in the trial
• Breeding farm with 110 sows. The sows were
  divided in 2 groups a trial group and a control
  group. Weaning was at day 21.
• Application of ASCOGEN
• 3g/day/sow given individually one time daily
  (equal 1 kg ASCOGEN/ton of feed).
• Recording
• - Sows Number of live born piglets
• - Piglets Weight of piglets at farrowing and at
  day 21,
• Diarrhoea index (0-no 1-little 2-heavy)

14

• No ASCOGEN With ASCOGEN
• Average Average
• Number of sows 23 24
• Total born 11,9 12,9
• Born alive 10,87
  -20,8 11,83 -18,9
• Alive after 24h 10,17 11
• Weaned 9,43 10,45
• Weight after 24h 1,73 1,73
• Weight at weaning 6,54 6,6
• Daily weight gain 229 232
• Diarrhoea index 011 018
• 19 16
• 1,51
• 22
• 0-no 1-little 2-heavy. 
• Comments Less losses of live born piglets in
  the group fed with ASCOGEN
• Diarrhoea index is lower in piglets from
  sows fed with ASCOGEN

15

• EFFECTS ON THE PERFORMANCE OF PIGLETS

16

• Effect on Feed intake, DLWG and FCR of weaned
  piglets
•  
• Julie Pikard, PhD
• Thesis Nottingham University
• 2002

17

• Background
• Piglets with severe enteric disease.
• 96 pigs housed in groups of 6 pigs per pen. (16
  groups)
• All piglets were weighed at weaning. The average
  weight at weaning was 6.5kg. (at 25 day of age)
• Result collection at day 50 of age.
• Trial diets were without zinc oxide or other
  digestive enhancers.
• Diets as follows
• Diet 1 Negative Control conventional starter
  diet fed to 25 days post weaning
• Diet 2 ASCOGEN fed from 7 days pre-weaning to
  weaning
• Diet 3 ASCOGEN fed from weaning to 25 days
  post weaning
• Diet 4 ASCOGEN fed from 7 days pre weaning to
  25 days post weaning

18

• Results
• Diet Feed Intake (kg)
  FCR DLWG
• 1 (Control) 8.8
  1.42 325gm
• 2 (7 days before weaning)
  9.75 1.12 395gm
• 3 (25 days after weaning)
  9.63 1.36 355gm
• 4 (7 days before 25 day after)
  10.0 0.90 430gm

19

• Effect on Feed intake, DLWG and FCR of weaned
  piglets
•  
• Farm Satellite Martilla
• Finland
• 2003

20
Feeding trial of small piglets in Marttila,
Finland Born 12. 07. 2003 Weaned 13. 08.
2003 Days 32 Delivered 24. 09. 2003 74 Test
feed 43 Control feed 48 30 male
14 female total 28 male 20
female total Weaning Av. W (kg) 9,03
8,70 8,93 9,73 9,18 9,52 Delivery Av. W
(kg) 33,23 33,38 33,28 31,46
30,15 30,89 Growth from weaning to
delivery ADWG (kg) 0,576
0,588 0,580 0,517 0,499 0,509 Feed
Weaning to delivery 1460 kg 33,954 kg/pig
Weight gain Weaning to delivery 24,35 21,37
FCR Weaning to delivery 1,39 1,59
21
Feeding trial of small piglets in Varpuluoma,
Finland Born 26. 07. 2003 Weaned 27. 08.
2003 Days 32 Delivered 06. 10. 2003 72 Test
feed 43 Control feed 48 16 male
26 female total 22 male 22
female total Weaning Av. W (kg) 10,66
9,65 10,04 10,73 10,93 10,83 Delivery A
v. W (kg) 35,53 33,04 34,01 30,14
32,24 31,16 Growth from weaning to
delivery ADWG (kg) 0,622
0,585 0,599 0,485 0,533 0,508 Feed
Weaning to delivery 1510 kg 36,829 kg/pig
Weight gain Weaning to delivery 23,97 20,36
FCR Weaning to delivery 1,54 1,81