Smoking and Type2 Diabetes Mellitus

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Smoking and Type-2 Diabetes Mellitus

• Toshimi Sairenchi, M.Sc.
• Ibaraki Health Plaza,
• Ibaraki Health Service Association, Ibaraki-ken,
  JAPAN

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Contents

• Epidemiology of type-2 diabetes mellitus in Japan
• Smoking and type-2 diabetes mellitus in
  middle-aged population
• Smoking and type-2 diabetes mellitus in elderly
  population
• Possible mechanism
• Conclusion

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Contents

• Epidemiology of type-2 diabetes mellitus in Japan
• Smoking and type-2 diabetes mellitus in
  middle-aged population
• Smoking and type-2 diabetes mellitus in elderly
  population
• Possible mechanism
• Conclusion

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Prevalence of diabetes among Japanese men
HbA1c()6.1 or medication
5.6Left bar in 1997
Right bar in 2002
All age
20-29
30-39
40-49
50-59
60-69
70-
Age (years)
(Ministry of Health, Labour and Welfare Japan,
2004)
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Prevalence of diabetes among Japanese women
HbA1c() 6.1 or medication
5.6 Left bar in 1997
Right bar in 2002
40-49
50-59
60-69
70-
Age (years)
(Ministry of Health, Labour and Welfare Japan,
2004)
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Notice
Type-2 diabetes mellitus among elderly is an
increasing public health problem.

• The proportion of diabetes of borderline type
  increased in the elderly for both sexes.

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Contents

• Epidemiology of type-2 diabetes mellitus in Japan
• Smoking and type-2 diabetes mellitus in
  middle-aged population
• Smoking and type-2 diabetes mellitus in elderly
  population
• Possible mechanism
• Conclusion

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Follow-up studies for smoking and type-2 diabetes
mellitus among middle-aged persons
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Sex-specific risk ratios for type-2 diabetes
mellitus according smoking habits among 275,190
men and 434,637 women
(Will JC. et al., 2001)
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Next Question
Is there a relationship between smoking and risk
of diabetes mellitus among elderly?

• Smoking is a risk of diabetes mellitus among
  middle-aged men and women.

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Contents

• Epidemiology of type-2 diabetes mellitus in Japan
• Smoking and type-2 diabetes mellitus in
  middle-aged population
• Smoking and type-2 diabetes mellitus in elderly
  population
• Possible mechanism
• Conclusion

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Age-specific risk ratios for type-2 diabetes
mellitus according to smoking habits among 39,528
men, Japan, 1993-2002
(Sairenchi T. et al., 2004)
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Age-specific risk ratios for type-2 diabetes
mellitus according to smoking habits among 88,613
women, Japan, 1993-2002
(Sairenchi T. et al., 2004)
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Contents

• Epidemiology of type-2 diabetes mellitus in Japan
• Smoking and type-2 diabetes mellitus in
  middle-aged population
• Smoking and type-2 diabetes mellitus in elderly
  population
• Possible mechanism
• Conclusion

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One of the possible mechanisms
Smoking
Oxdative stress
Insulin action
Diabetes mellitus
Bridges AB. et al., 1993 Paolisso G, et el., 1993
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Contents

• Epidemiology of type-2 diabetes mellitus in Japan
• Smoking and type-2 diabetes mellitus in
  middle-aged population
• Smoking and type-2 diabetes mellitus in elderly
  population
• Possible mechanism
• Conclusion

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Smoking and type-2 diabetes

• Smoking is a risk factor of type-2 diabetes
  mellitus not only among middle-aged but also
  among elderly men and women.