Chromosomal abnormality after ICSI

1
Chromosomal abnormality after ICSI
spontaneous conception
ICSI
(1082 cases)
56952
34910
Sex chromosomal
9 (0.83)
0.19
0.23
(45X, 47XXX, 47XXY )
autosomal
0.21
0.61
9 (0.83)
(21 trisomy 5 cases)
10 (0.92)
others
total
28 (2.6)
0.92
0.84
2
Chromosomal abnormality in infertility couple of
ICSI
incidence
report
No. of couples
female
male
305
?
3.3
3.3
2.1
5.5
?
434
?
1,792
4.0
1,140
4.5
9.8
?
Incidence of chromosomal abnormality in natural
population is 0.6 .
3
Preimplantation genetic diagnosis
(PGD)
4
(No Transcript)
5
Procedure of embryo biopsy
6
FISH (Fluorescence in situ hybridization)
Each chromosome is identified by differently
coloring.
7
Diagnosis 18 trisomy female
8
Preimplantation genetic diagnosis has ethical
problems and is strictly regulated by the Society
of OB/GYN in Japan.
9
Regulation for PGD
UK
severe genetic diseases
France
severe genetic diseases
Germany
prohibited
Austria
prohibited
USA
No regulation
Australia
severe genetic diseases
Korea
severe genetic diseases
Japan
severe genetic diseases
10
Ethical aspects of ART
preimplantation genetic diagnosis
gamete donation
embryo donation
surrogacy
11
oocyte donation
donor
no ovary
healthy
(premature ovarian failure)
12
oocyte donation
sisters ?
no ovary
healthy
(premature ovarian failure)
13
sperm donation
donor
azoospermia
healthy
14
sperm donation
brothers ?
father ?
azoospermia
healthy
15
embryo donation
donor
azoospermia
no ovary
Who is the real parent?
16
surrogacy
surrogate
no uterus
17
Regulation for ART in the world
Germany
Japan
USA
Australia
France
Sweden

?
?
?

Sperm donation

?
?


Oocyte donation

?
?

Embryo donation


?



Surrogacy



?

Host mother
18
Thank you for your attention