AMERICAN COLLEGE OF RADIOLOGY

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AMERICAN COLLEGE OF RADIOLOGY
March 23, 2006
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http//upict.acr.org
OUR MISSION To foster the ongoing development
of widely acceptable consistent imaging
protocols and quality control procedures across
the multiple sites and modalities needed for
case accrual and statistical power through the
expertise and participation of radiologists,
radiation oncologists, nuclear medicine
physicians, other medical specialists, medical
physicists, clinical trial experts and industry.
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Rationale

• Uniform protocols that can be used in assessing
  efficacy in therapeutic trials are also of great
  interest both to trialists and to industry for
  accelerating drug development process.

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To address the needs of all affected parties, it
is evident that imaging acquisition standards
must

• account for variations in technology currently
  being used
• provide sufficient detail with regard to format,
  structure, and implementation to ensure
  consistency and reproducibility across platforms
  and clinical sites
• reasonably accommodate imaging procedures in the
  context of usual care
• acknowledge rapid evolution/progress of
  technology and incorporate change management
  while providing periods of stability (measured in
  a specified number of years) through
  predictable/announced version control
• acknowledge/reference the needs and
  responsibilities of governmental granting
  agencies supporting clinical trials (e.g.
  NCI/CTEP/CIP) and regulatory agencies (e.g. FDA)
  
• be used to establish consistency in clinical
  trials and should not dictate the practice of
  medicine outside the appropriate clinical trials

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UPICT Template

• Uniform Protocol for ltmodalitygt of the ltbody part
  and/or disease entitygt
• Goal/Objective of Imaging
• Responsibilities of CRO or Imaging Core
  Laboratory
• Reader Selection
• Platform/Equipment Specification
• Image Data Acquisition
• Frequency of Imaging

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UPICT Template

• 7. Image Quality at Imaging Site
• 8. Reading environment and image presentation
• Workstation/ Viewing Conditions
• Interpretation
• 11. Equipment data considered for specification
• CT example parameters
• MRI example parameters
• Radiography example parameters
• PET scanners example parameters
• PET/CT scanners example parameters
• 12. More detailed technique data considerations

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UPICT Representatives

• American College of Radiology
• Food Drug Administration
• National Cancer Institute
• Radiological Society of North America
• Society of Nuclear Medicine
• American Association of Physicists in Medicine

• American Society of Clinical Oncology
• National Electrical Manufacturers Association
• American College of Radiology Imaging Network
• Radiation Therapy Oncology Group

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End