Faculty Development Within the Expanding Translational Mission of the University

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Faculty Development Within the Expanding
Translational Mission of the University
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Translational Research 101

• BU
• Academic Medical Center culture
• NIH, HHMI
• Strategies

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BU Medicine Research Highlights 2008

• 2008 Nobel Prize in Chemistry
• Clinical Translational Science grant funded!
  (outscored Harvard)
• Genome Sciences Institute formed
• NEIDL construction near completion
• Framingham Heart Study renewal funded with
  genetics study

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Creating a Global University in Health Sciences

• Primary care practices in Lesotho, Africa Viet
  Nam
• Research collaborations on virtually every
  continent.
• Public Health research Pakistan, Africa, Asia
  S America
• Dental Institute in Dubai

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United Arab Emirates
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Health Sciences Strengths

• BUMC
• Urban International Health
• Neurosciences
• Multiple NIH funded Centers
• CRC
• Biomedical Engineering
• College of Arts Sciences, Sargent, School of
  Social Work

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Translational Research 101

• BU
• Academic Medical Center culture
• NIH, HHMI
• Strategies

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Understanding Academic Medical School Culture

• Top 15 in research funding Hyper competitive
• Next 40 Room for very diverse contributions
• For many state universities, teaching care are
  major goals.

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Academic Promotions

• Rank Recognition
• Assistant Local/Regional
• Associate National
• Professor International

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CP Snow

• Two cultures the scientific revolution 1960

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Cultural Differences
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Standard Model
Laboratory Research
Clinical Research
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Revised Standard Model
Laboratory Research
Clinical Research
Translational Research
Population Research
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Further Revisions.....
Laboratory Research
animal models
carcinogenesis
genetics
diet environment
immunology
molecular epidemiology
new drug development
Population Research
Clinical Research
behavioral screening research
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How Translational Research Does Work
Care
Outcomes research
Health Services research
Behavioral research
diet environment carcinogenesis molecular
epidemiology
genetics immunology animal models new drug
development

Population Research
Laboratory Research
Clinical Research
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Centers Facilitate Translational Research

• CVI Cancer
• Physiology
• Pharmacology
• Biochemistry
• Medicine
• Psychiatry

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Partnerships Required
Professional Societies
Academic Medical Centers
Clinical Research
NIH
Health Insurance

• Pharmaceuticals

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Translational Research 101

• BU
• Academic Medical Center culture
• NIH, HHMI
• Strategies

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James Wyngaarden

• The Clinical Investigator as an Endangered
  Species
• Presidential address,
• Assoc Am Physicians 197992-15.

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3 NIH Funding Streams

• Lab
• Clinical Translational
• Population Science

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Academic Life Cycle
R01s P01
Associate Professor
Assistant Professor
Instructor
Professor
Fellow
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Percentage of Traditional NIH Grants Awarded to
Young Investigators Over Time
Over 55 years old
46-55 years old
36-45 years old
lt36 years
Source NIH
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HHMI Grad to Med Pilot Program

• Academia looses MD/PhDs to private practice
• Increasing numbers of PhDs in clinical
  departments
• Pilot program Train PhDs in translational
  research

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Translational Research 101

• BU
• Academic Medical Center culture
• NIH, HHMI
• Personal Strategies

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Research tracks

• Basic Science lab
• Translational lab Clinically applicable problem
• Translational clinical 1st human trials
• Clinical Trialist large randomized trials
• Epidemiology outcomes

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Training

• Translational lab MD,PhD
• Translational clinical 2-3 lab years biostat,
  Federal regs, pharmacology
• Clinical trialist MS, MPH
• Epidemiology, outcomes MPH

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Picking Mentors

• Need an advisory board
• NIH funded
• Collegial
• Track record with junior faculty
• Separations traumatic?

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Academic Street Smarts

• Get rigorous training
• Find mentors - but establish your independence
• Procrastination is deadly - write!
• During training, submit a grant to multiple
  funding agencies
• Resubmit the grant

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Academic Street Smarts

• Nothing beats intelligence except experience,
  commitment drive
• Making a contribution in science or medicine
  isnt easy for anyone

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You really do have to be good at something

• From A Beautiful Mind one totally original
  idea to move the field
• Find a new field become the international
  expert.
• Dont try to compete in mature fields full of
  senior investigators.

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Simones Maxims SuccessClinical Cancer Research
52281, 1999

• Depends on recognizing adapting to ones era.
• Academic medicine is a noble calling
• Watch temptations to compromise mission by
  alliances for money power.

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Be aware of hardball

• Less here than elsewhere
• Get collaboration agreements in writing,
  especially authorship order

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Swimming with SharksRichard J Johns, Prof
Biomed Engineering, HopkinsAssoc Am Physicians
8844, 1975

• Assume unidentified fish are sharks

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Swimming with SharksAssoc Am Physicians 8844,
1975

• Counter any aggression promptly
• Use anticipatory retaliation
• Divert an organized attack

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Swimming with SharksAssoc Am Physicians 8844,
1975

• If someone is bleeding, get out of the water.
• If bitten, do not bleed.

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Fox Hunt When in deep trouble- look straight
ahead- say nothing.
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Mel Levines Survival Guidelines

• Be happy, enthusiastic (not tired, overwhelmed).
• Support your expenses
• Teach well
• Avoid low yield rituals (e.g. meetings)
• Develop a focus of expertise
• Dont burn bridges
• Watch for turf issues
• Collaborate nurture national relationships
• See your boss regularly (dont ask for things.)

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Goal for BUMC the best place to learn, teach
discover

• Quality of Professional Life

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Boston University Medical Campus