David W' Kimberlin, M'D'

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David W. Kimberlin, M.D.

• Associate Director
• UAB Pittman General Clinical Research Center

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UAB K30 Program

• Funded by NIH to help medical schools train
  fellows and junior faculty for careers in
  clinical research
• UAB has been funded for 7 years recently renewed
  for 5 additional years
• UAB K30 Executive Committee
• Larry Moreland Steve Glasser
• Ned Hood Jack Barnette
• George Howard Dick Kaslow
• Administrator Audrey Wrenn (Audrey.Wrenn_at_ccc.uab.
  edu)

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K30 UAB Program

• Survey Course
• For beginning fellows (residents)
• 20 hours over 2 week period
• Clinical Research Training Program (CRTP)
• Certificate program
• 2 hours/week of didactic/interactive lectures
  over 1 year
• Need a mentor(s) and a project
• Project just an idea OR funded project

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K30 UAB Program

• Masters in Clinical Research
• Degree program
• Courses in SOPH
• Need protected time, e.g. T32, K23
• Senior fellows, junior faculty members

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Loan Repayment for Clinical Research

• 5 different loan repayment programs
• Up to 35,000/year for educational debt for
  health professionals pursuing careers in
  clinical, pediatric, contraception and
  infertility, or health disparities research
• Key requirements
• doctoral-level degrees
• devote 50 or more of time to non-profit or
  government-funded research
• Have educational debt equaling at least 20 of
  institutional base salary
• For details on requirements and application
  process www.lrp.nih.gov

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UAB Pittman GCRCPurpose

• Clinical research infrastructure for
  investigators with NIH funding industry funded
  studies (payback to grant)
• Some investigator-initiated pilot studies
• Training medical students, residents, fellows
  and faculty
• http//www.gcrc.uab.edu
• 934-4852

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GCRC Facilities

• Inpatient
• 9th Floor MEB ? 3rd Floor CPM (late 2007)
• Childrens Hospital
• Outpatient
• 9th Floor MEB ? 1st Floor FOT (late 2007)
• TKC
• Childrens Hospital
• 1917 Clinic
• Rationale
• Convenience for patients
• Convenience for researchers
• Separation of research from clinical care

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Services and Programs Provided by the Pittman
GCRC
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Services and Programs Provided by the Pittman
GCRC
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Pittman GCRCFunding Possibilities

• Clinical Research Feasibility Funds (CReFF)
• Foster junior faculty involvement in clinical
  research
• Senior faculty changing career paths and
  proposing to conduct clinical research
• Up to 20,000 for a one-year project period
• Laboratory, personnel and patient-related costs
  of the project
• Salary support not be available for PI
• Additional year of funding may be made available
  based on the research priority and the
  recipients progress report

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Scientific Advisory Committee (SAC)

• Prioritizes projects for GCRC use
• NIH-funded clinical research MUST be given
  preference
• Designates Category of Protocol (A, B, D)

• Sets general policies
• Establishes admission policies
• Establishes charges for industry protocols

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Clinical and Translational Science Award (CTSA)

• Goal 1
• Establish the CCTS to provide ACCESS (Assistance
  through Centralized Communication and Essential
  Support Services) to investigators to enhance
  clinical and translational research and
  collaboration.

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Clinical and Translational Science Award (CTSA)

• Goal 2
• Train and develop clinical and translational
  investigators to become principal investigators
  and productive members of research teams.

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Clinical and Translational Science Award (CTSA)

• Goal 3
• Facilitate utilization of existing resources and
  provide new resources for clinical and
  translational investigators.

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Clinical and Translational Science Award (CTSA)

• Goal 4
• Emphasize research that is important given UABs
  unique geographic location and history (i.e.,
  health disparities research) and that utilizes
  some of our unique strengths (i.e., outcomes
  research and drug discovery).

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Clinical and Translational Science Award (CTSA)

• Goal 5
• Institute a Self-Monitoring and Improvement
  Program at the Center level and quality assurance
  at the University level.

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CCTS Components

• 8 suggested by the NIH
• CCTS Pilot Awards Program
• Biomedical Informatics
• Design, Biostatistics and Clinical Ethics
• Regulatory Knowledge and Support
• CCTS Clinical Research Units
• One Great Community
• Translational Technologies and Novel
  Methodologies
• Research Education, Training and Career
  Development
• 1 additional
• Drug Discovery

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• For any questions regarding clinical research
  issues/career opportunities
• Larry Moreland, M.D.
• Associate Dean for Clinical Research
• larry.moreland_at_ccc.uab.edu
• 934-2130