Progress in the RNOHIOMS Joint Academic Strategy

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Progress in the RNOH-IOMS Joint Academic Strategy
Trust Board July 2008

• David Marsh
• Professor of Clinical Orthopaedics, Institute of
  Orthopaedics and Musculoskeletal Science
  University College London
• Acting RD Director, Royal National Orthopaedic
  HospitalStanmore, UK

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Academic Health Science Centre

• Joint Academic Plan
• integration of UG and PG education
• RD management into IOMS
• Research strategy

CLINICAL
EXCELLENCE,INTEGRATION
EDUCATION
RESEARCH
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Research Strategy

• Focused on musculoskeletal system but full
  spectrum

Health services research
Basic science
Clinical trials
Translational Experimental

• Five themes, building on track record and patient
  needs
• Innovative implant design
• Cell therapy and tissue engineering
• Disability and improvement of quality of life
• Building the musculoskeletal evidence base
• Sarcoma medicine

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Institute of Orthopaedics and Musculoskeletal
Science
Academic Research Board
Research Committee
Education Committee
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08
09
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11
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Expenditure
NHS RD
UCL
Grant targetoverheads, contributions to salary,
SCRF profit
MRC stem cells in nonunion 300k
Pfizer fracture accelerating drug 500k
TSB grant 500k
NIHR Applied Research Programme 2m
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Update

• Research Committee
• Clinical research facility
• Cell therapy GMP facility
• Funding

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Research Committee
Rob Hurd Exec Team Nerina Bee Academic Business
Development Joseph Fatukasi RD Manager Simon
Grange Clinical SL, Assistant RD
Director Richard Keen Research-active
consultant Sue Marchetto Lead research
nurse David Marsh Clinical Professor, RD
Director

• Meeting fortnightly
• Agenda evolving
• Research governance trial masterfiles,
  investigator files, GCP
• Clinical research, pipeline
• Links with LCRN, Deanery etc
• First meeting of Academic Board planned for
  September

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Cell-based therapy

• Previous clinical trials in ACI
• Preclinical work on bone, collagen
• Regenerative Medical Systems UK
• Lease signed for Centennial Park
• Permanent staff coming in Sep
• On stream Q1 - 2009
• Scientific Board
• Translational teams
• Bone,Tendon,Cartilage

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MRC Translational Research Call

• 241m extra, most on translational research
• Bottlenecks
• Pan-UCL bid going in
• MRC Centre for Cell and Gene Therapy
• Stanmore hopefully to contribute cell therapy in
  the musculoskeletal system

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Funding

• Extra 196k from NIHR
• Grants secured
• MRC cells in impaction grafting
• Vibration therapy in distraction osteogenesis
• Instrumented IM nail
• ITAP
• 15 trials in the pipeline
• Grants in preparation

Full economic costing