IRAP

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Welcome!
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IRAP?

• interleukin 1receptor antagonist protein
• brandname of technology used to obtain Autologous
  Conditioned Serum (ACS)

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(No Transcript)
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What does Interleukin1(IL-1) do?

• Following joint injury there is up regulation of
  synthesis of IL-1
• IL-1 drives
• Pain
• Inflammation
• Degeneration

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What's The Big Deal?

• 100 non chemical uses the bodys own treatment
  mechanism
• Effective
• Safe

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Irap Syringe
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Sterile Acquisition

• IRAP syringe is used to draw fresh venous blood
  from the horse
• Mild sedation allows a higher yield (proportion
  of plazma to red cells is higher)

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24 hour Incubation

• White blood cells produce therapeutic proteins
  through their physical contact with the glass
  beads during incubation at 37C

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Centrifugation
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Sterile Processing
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Filtering into Syringes Freezing
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Injecting into Joint(s)
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Controlled studies
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Benefits of ACS

• 100 autologous
• antiinflammatory
• relieves pain
• regenerative
• all components are in physiological concentration
  only
• all components act synergistically -gt more
  effective
• safe so far not a single infection

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For what type of problems ?

• Horses which have a well diagnosed arthritis
  condition with no specific pathology such as
  osteo-chondral bone fragments, OCD lesions, etc.
• In addition those horses that have had hyaluronic
  acid (HA) and/or cortico-steroids with little or
  no improvement.

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Post Arthroscopy

• Post-Arthroscopy joints with cartilage lesions
  and scratches but not totally destroyed cartilage
  areas.

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Post Surgery

• Maintenance therapy for those horses with more
  severe joint disease

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German Recommendations

• Amount 2-8 ml depending on size of joint
• Frequency every 4-8 or 8-16 days
• Repetitions 0- 3X (i.e. 1-4 injections in a row)
• Our experience stifles require higher volume
  10-15 ml

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Cost?

• IRAP syringe, sample acquisition, incubation,
  centrifugation filtration into multiple
  syringes for immediate and future injection.
• Injection fee sterile scrub, filtering IRAP,
  sterile joint injection /-antibiotic, sedation,
  bandaging