Hair Cell and Meddis Hair Cell Model

1
Hair Cell and Meddis Hair Cell Model

• Xiaoxiang Gong

2
Outline

• Function of Hair Cells
• Hair Cell Model Meddis Model
• Simulation Result for the Meddis Model
• Phase Locking

3
Function of Hair Cell
4
Meddis Model for Hair Cell
Synaptic cleft Outside the Hair cell
Hair cell

• Spike Probability is proportional to the amount
  of transmitter in the synaptic cleft.

5
Simulation Result for Meddis Model -- from
Auditory Toolbox

• Stimulus Single tone (1KHz) with amplitude
  scales on silent background.
• Spontaneous rate
• Onset rate the initial peak value
• Steady state rate adaptation level

6
Phase Locking

• The auditory nerve will tend to fire at a
  particular phase of a stimulating low-frequency
  tone (Period Histogram). So the inter-spike
  intervals tend to occur at integer multiples of
  the periods of the tone (Inter-spike Interval
  Histogram).
• Phase locking depends on the stimulus frequency
  with high frequency tones ( 3kHz) phase
  locking gets weaker.

7
Phase Locking-- Construction of Period Histogram
8
Phase Locking-- Period Histogram Inter-spike
Interval Histogram
AN fibers fire at integer multiples of the
stimulus period, not necessarily on every period
9
Phase Locking-- Period Histograms from Meddis
Model

• Showing a half-wave rectified version of the
  stimulus

10
Phase Locking-- Inter-spike Interval Histograms
from Meddis Model
For 1KHz sinusoid input

• AN fibers fire at intervals related to stimulus
  frequency.

11
(No Transcript)