Investigation: Molecules to Man and back

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Investigation Molecules to Man (and back)
Robert P. Kimberly, M.D. Howard Holly Professor
of Medicine Senior Associate Dean for
Research Director, UAB Arthritis and
Musculoskeletal Center
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Investigation M2M and back

• How to establish a career

Identify a mentor, and have a coffee at
least once a month
Organize your lab, and dont hesitate to use
the HHMI website
Understand the expectations for promotion
Research productivity Teaching performance
Service (resource, admin, clinical)
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Investigation Identify a mentor

• Lucy's Coffee Tea2007 University
  Blvd.328-2007In addition to coffee and tea,
  Lucy's offers sandwiches, salads, baked goods and
  more at good prices. Warm, friendly atmosphere,
  retro furniture and funky artwork. City Scene
  gave high marks to the smoked turkey sandwich,
  with smoked gouda, tomato chutney and arugula,
  served on toasted ciabatta bread from Edgar's
  Bakery.

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Investigation Organize your lab

• HHMI Making the Right Moves, A Practical Guide
  to Scientific Management for Postdocs and New
  Faculty (http//www.hhmi.org/grants/pdf/labmgmt/b
  ook.pdf)
• Staffing your lab
• Mentoring
• Getting funded
• Project and data management
• Setting up collaborations
• Publications
• Technology transfer

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Investigation Organize your lab

• Occupational Health Safety - radiation safety,
  chemical safety, etc. (http//www.healthsafe.uab.e
  du/pages/educationandtraining/educationandtraining
  .html)
• Use of Animal Subjects general information and
  species specific training (http//main.uab.edu/int
  ernal/show.asp?durki34597)
• Use of Human Subjects initial training and
  continuing education(http//main.uab.edu/show.asp?
  durki58146)
• Effort Reporting (https//courses.uab.edu/)

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Investigation Organize your lab

• Mandatory certifications
• UAB Code of Conduct
• (http//www.hrm.uab.edu/codeofconduct)
• HIPAA
• (http//www.hipaa.uab.edu/training.htm)

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Investigations Organize your lab
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http//main.uab.edu/research

• Administration and Oversight
• Animal Resources Program (ARP)
• Clinical Trials
• Conflict of Interest Review Board
• Grants and Contracts Accounting
• Institutional Animal Care Use Committee (IACUC)
  
• Institutional Review Board (IRB) for Human Use
• Occupational Health Safety
• Office of Grants and Contracts Administration
  (OGCA)
• Office of Research Compliance
• Office of Sponsored International Programs (OSIP)
  
• Research Foundation (UABRF)
• University Counsel Office

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http//main.uab.edu/research

• Facilities
• Alabama Department of Public Health (ADPH)
• Birmingham Regional Emergency Medical Services
  System (BREMSS)
• Birmingham Veterans Affairs Medical Center
  (BVAMC)
• Centers at UAB including those based in
  departments and schools
• Jefferson County Department of Health (JCDH)
• Pittman General Clinical Research Center GCRC
• Southeast Biosafety Laboratory Alabama Birmingham
  (SEBLAB)
• Southern Research Institute
• UAB Clinical Facilities

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http//main.uab.edu/research

• Forms
• Animal Resources Program(ARP) Forms
• Conflict of Interest Review Board (CIRB) Forms
• Grants and Contracts Accounting Forms
• Institutional Animal Care and Use Committee
  (IACUC) Forms
• Institutional Review Board for Human Use (IRB)
  Forms
• Occupational Health and Safety (OHS) Forms
• Office of Grants and Contracts Administration
  (OGCA) Forms
• UAB Research Foundation (UABRF) Forms

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http//main.uab.edu/research

• Graduate and Postdoctoral Training
• International Research Training Programs
• Office of Postdoctoral Education
• The Graduate School
• Technology Transfer and Economic Development
• Office for the Advancement of Developing
  Industries (OADI)
• UAB Research Foundation
• UAB Research Park at Oxmoor

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http//main.uab.edu/research

• Regulatory Training
• Check courses taken
• Effort Reporting
• HIPAA
• Institutional Animal Care and Use Committee
  Training (IACUC)
• Occupational Health and Safety (OHS)
• Office of Institutional Review Board for Human
  Use (IRB)

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http//www.uab.edu/uasom/research/
UAB core facilities Budget and grant writing
links Mentoring resources Funding
opportunities Compliance
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Investigation Expectations

• Research Productivity
• How to choose an area for investigation

Think broadly the NIH Roadmap
Look at UAB UWIRC Centers
Look for translational opportunities
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Investigation Expectations
Research Productivity Funding

• Government Resources (www.grants.gov)
• Federal
• State
• Private Resources
• Foundations and Associations
• Nonprofit Centers
• Charities
• Internal Funding University Sponsored

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Investigation Expectations

• NIH resources for new investigators
• http//grants.nih.gov/grants/new_investigators/res
  ources.htm
• Identify appropriate individual NIH career awards
  by using the wizard
• http//grants.nih.gov/training/kwizard
• All about grants tutorials
• http//www.niaid.nih.gov/ncn/grants/default.htm
• Annotated grant
• Annotated summary statement

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NIH Small Grant Program (R21)

• New, exploratory and developmental research
  projects
• Supports early stages of project development
• May involve considerable risk but may lead to a
  breakthrough in a particular area, or to the
  development of novel techniques, agents,
  methodologies, models or applications that could
  have major impact on a field of biomedical,
  behavioral, or clinical research
• Should break new ground or extend previous
  discoveries toward new directions or applications

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Associations Foundations

• American Heart Association
• American Lung Association
• American Cancer Society
• Arthritis Foundation
• Howard Hughes Medical Institute
• National Marfan Foundation
• Ellison Medical Foundation
• Cystic Fibrosis Foundation

• The Alzheimers Association
• FRAXA Research American Heart Foundation
• American Diabetes Foundation
• Leukemia and Lymphoma Society.
• Juvenile Diabetes Research Foundation
• National Neurofibromatosis Foundation
• Coulter Foundation

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UAB Nominates Candidates

• Ellison Medical Foundation (Aging)
• The John Merck Fund (Developmental Disabilities
  in Children)
• The W. M. Keck Foundation's Distinguished Young
  Scholars in Medical Research
• Pew Scholars Program
• Burroughs Wellcome Biomedical Scholars
• Howard Hughes
• Daymon Runyon Foundation
• Searle Scholars

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Investigation updates on funding

• Join the UABRADM listserve
• (http//www.uab.edu/uabra/uabradm_request.htm)
• Join the Community of Science - keep your
  biosketch updated!
• (www.cos.com)
• Subscribe to the NIH NEXUS Listserve
• (http//grants.nih.gov/grants/nexus.htm)
• Search
• (www.grants.gov)
• Talk to your colleagues

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The Independent Investigator

• Publishes in high quality journals in a given
  area
• Serves as a principal investigator of grants or
  contracts
• Significant and sustained extramural funding
• Supervises graduate students, post doctoral and
  clinical fellows
• Initiates and participates in research
  collaborations

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Investigation M2M and back

• How to establish a career

Identify a mentor, and have a coffee at
least once a month
Organize your lab, and dont hesitate to use
the HHMI website
Understand the expectations for promotion
Research productivity Teaching performance
Service (resource, admin, clinical)
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Investigation Expectations
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Investigation Expectations
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Investigation Expectations
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CTSA Additional Considerations

• NCRR K12, K30, M01 and Roadmap T32 and K12 awards
  will be reconfigured into the CTSA program
• Non-NCRR and Roadmap NIH categorical awards will
  not be included in the reconfiguration
• It is anticipated that they will benefit from the
  CTSA infrastructures
• CTSA will be expected to complement and interact
  with existing centers that are funded by the
  categorical institutes of the NIH

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CTSA Additional Considerations

• CTSA Key Components
• 1. Development of Novel Clinical and
  Translational Methodologies
• 2. Pilot and Collaborative Translational and
  Clinical Studies
• 3. Biomedical Informatics
• 4. Design, Biostatistics, and Clinical Ethics
• 5. Regulatory Knowledge and Support
• 6. Participant and Clinical Interactions
  Resources
• 7. Community Engagement
• 8. Translational Technologies and Resources
• 9. Research Education, Training and Career
  Development
• 10.Self-Monitoring and Improvement Program

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The Clinical and Translational Science Award
(CTSA) platform for leveraging the MCRC
mission

• Robert P. Kimberly, M.D.
• Principal Investigator, UAB MCRC
• September, 2006

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Priority Research Themes and Enabling Platforms
Priority Research Themes
Neuro- sciences
Infectious Diseases Vaccines
Immunology, Autoimmunity Trans-plantation
Diabetes, Obesity, and Metabolic Diseases
Cardio- vascular Biology
Cancer

• Key (mission-critical) requirements and
  transforming factors for future productivity,
  accelerated growth, and
• resource investments
• Expand leadership and faculty
• Increase technological innovation and research
  capacity
• Promote research training and education
• Manage resources responsibly and effectively
• Align SOM mission and research planning with the
  UAB Health System

Fundamental Research
Molecule
Faculty, research technologies, methodologic
resources, space, and collaboration/coordination
Enabling Platforms
Individual
Clinical Research spans prospective,
randomized, clinical trials to population-based
studies
Population
Care Delivery and Disease Prevention (UAB Health
System)
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Five Key Recommendation Areas

• A) Recruit, retain, and maintain leadership and
  faculty expertise.
• B) Develop, re-engineer, and improve enabling
  platforms, technological innovation, and research
  capacity.
• C) Enhance current and develop new paradigms for
  graduate/post graduate education and training,
  creating integration and flexibility that allows
  recruitment of the best and brightest future
  scientists.
• D) Enhance organizational stewardship and
  effectiveness.
• E) Reduce administrative barriers for conducting
  research.

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Leadership and Faculty Recruitment

• Complete ongoing leadership recruitments for The
  Comprehensive Cancer Center, The Comprehensive
  Diabetes Center, The Heflin Genetics Center, and
  fundamental immunology
• Initiate recruitment efforts for new group
  leaders for bioinformatics, cardiovascular
  biology, medical informatics, vaccinology, and
  experimental imaging
• Aggressively recruit 30 research faculty per year
  over the next 5-7 years, with the expectation
  that half of those recruited will be funded at
  the time of appointment. Recruitment should be
  focused on investigators in basic sciences,
  translational investigation and outcomes and
  disparities research.
• Create a Comprehensive Neurosciences Center and
  recruit or identify a Director.
• Enhance cooperative recruiting efforts and
  coordinate investments with other Schools at UAB
  and with Southern Research Institute.

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Enabling Platforms, Technological Innovation, and
Research Capacity

• Enhance the currently available imaging
  technology dedicated to research on humans,
  experimental animals, and live cell/tissue
  specimens by expanding capacity of existing
  technologies, acquiring of new technologies and
  recruiting academic experts in selected imaging
  modalities.
• Enhance model organism capacities, including
  genetically engineered mice and other systems, to
  complement cellular, molecular, and behavioral
  studies.
• Develop research capabilities in medical
  informatics.
• Facilitate translational initiatives by
  increasing the service capabilities in genomics
  and proteomics, bioinformatics, study design,
  outcomes, biostatistics and innovative study
  techniques, and drug discovery.
• Coordinate and consolidate research core
  management, expand core capabilities and develop
  an on-going process for needs assessment and
  innovation. Investigate opportunities for
  collaborative cores involving other universities,
  Southern Research Institute and other partners.

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Education and Training Opportunities

• Establish a single administrative structure for
  graduate programs in the biomedical sciences that
  will also provide administrative support for T32
  and other training/fellowship grant applications.
• Create new interdepartmental, interdisciplinary
  training programs that will serve as magnets for
  recruitment and foci for faculty involvement.
• Develop synergies between the graduate and
  medical curricula and create PhD and other
  advanced degree opportunities at the medical
  postgraduate level.
• Develop a more competitive national position
  through more effective recruitment, appropriate
  stipends, and expansion of graduate programs
  commensurate with the increase in faculty.
• Increase institutional resources for graduate
  stipends/tuition costs to provide complete
  support for the first 18-24 months of the
  graduate student curriculum.
• Establish infrastructure support for clinical
  research trainees through support of faculty
  mentoring and space for clinical research
  training activities, in alignment with other
  translational science initiatives.

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Organizational Stewardship and Effectiveness

• 17. Establish mechanisms to recognize the
  continuing leadership and research contributions
  of our most productive faculty, including endowed
  chairs and other support avenues.
• 18. Expand the development office to secure more
  endowments, gifts, and unrestricted funds from
  the philanthropic community. Efforts should be
  made to assure that donors interested in specific
  diseases are made aware of first-rate basic
  scientists as well as clinicians.
• 19. Promote ongoing faculty productivity and
  development through bridge funding mechanisms and
  by providing opportunities for re-tooling of
  academic and research skills, including internal
  and external sabbaticals and pilot funding in
  targeted research areas.
• 20. Formalize a process to annually review
  faculty accomplishments and to identify and
  nominate marquee faculty for national
  distinction (i.e., NAS, IOM, HHMI, etc.).
• 21. Recognize and promote/reward non-tenure track
  faculty who lead research service cores.

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Organizational Stewardship and Effectiveness
(continued)

• 22. Enhance organizational efficiency and
  effectiveness by streamlining operational
  redundancies in administrative and departmental
  structures, implementing regular five year
  reviews of departments, and examining tenure and
  compensation policies.
• 23. Facilitate a more effective relationship with
  the VA.
• 24. Create a joint strategic planning office
  involving the UAB Health System, HSF, and the SOM
  to promote and reinforce alignment between the
  SOM and the clinical enterprise. In parallel,
  promote similar efforts with Childrens Hospital.

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Overcoming Administrative Barriers

• 25. Help define accountability (including from
  the perspective of user groups) of all central
  administrative units that support the research
  mission. This must include expectations of
  competence, efficiency, and a customer-service-ori
  ented approach to dealing with constituents.
• 26. Assure that all training requirements for
  researchers are well thought out and available
  via media that provide efficacious and efficient
  compliance.
• 27. Develop procedures for the timely negotiating
  of contracts, CDAs, and MTAs that allow UAB
  investigators to compete at a level comparable to
  peers at other institutions.
• 28. Enable clinical research through the
  continued development of the Office of Human
  Research and the implementation of
  research-enabling support software.
• 29. Assure that electronic grant submission
  mechanisms are in place and user-friendly.
• 30. Facilitate intra- and inter-institutional as
  well as international collaborations by
  establishing a searchable database of faculty
  expertise and research interests and establishing
  an International Research Support Office.

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Strategic Planning Implementation Committee
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SOM Research Strategic Plan
Good thoughts are no better than good dreams
unless they be executed.
Ralph Waldo Emerson
Just do it
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The UAB SOM Strategic Plantransition from
planning to operations

• Robert P. Kimberly, M.D.
• Senior Associate Dean for Research
• June 15, 2006

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