Univ. College London

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NEW INSIGHTS INTO THE ROLE OF THE BASAL FOREBRAIN
IN CORTICAL PLASTICITY AND ATTENTION
Univ. College London Paul Bentley
William Griffith
Centr. Nat. Rech. Sci. Paris Jean-Marc Edeline
Martin Sarter
Randy D Blakely Vanderbilt Univ Sch Med
Laszlo Zaborszky
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WHERE IS THE BASAL FOREBRAIN?
Reil (1809) unnanmed substance Meynert (1872)
nucleus basalis Cholinergic hypothesis of
AD Bowen et al., 1976 Davies and Maloney, 1976
Whitehouse et al., 1981 Basal forebrain in
reward De Long, 1971 Rolls et al., 1976 Basal
forebrain in cortical activation Detari and
Vanderwolf, 1987 Basal forebrain in cortical
plasticity Silito and Kemp, 1983 Sato et al.,
1987 Juliano et al, 1989 Merzenich,Weinberger,
Edeline Basal forebrain in attention Dunnett et
al., 1991 Gallagher, 1995 Everitt and Robbins,
1997 Paus et al., 1997 Sarter and Bruno, 1997
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CORTICOPETAL CELLS (N. BASALIS MEYNERT) IN THE
HUMAN BASAL FOREBRAIN PROBABILISTIC MAPS OF THE
BF
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CHOLINERGIC INNERVATION IN VARIOUS CORTICAL AREAS
Avendano et al.,1996
Mesulam et al., 1986
Cuello
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L. Zaborszky Neuroanatomy of Basal Forebrain
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R. Blakely Molecular mechanisms of presynaptic
cholinergic homeostasis
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W. Griffith Intracellular calcium homeostasis in
BF cholinergic neurons from behaviorally
characterized rats
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M. Sarter Real-time monitoring of cholinergic
activity in behaving rats using enzyme-selective
microelectrodes
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J-M Edeline Role of acetylcholine in the
induction and expression of auditory cortex
plasticity
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P. Bentley Attention-related activations are
increased by physostigmine in AD but decreased
in healthy controls
Controltask
Controltask placebogtphyso
E
ADtask physogtplacebo
ADtask
F
T
AD - Controltask
Cont-ADtask placebogtphyso
Z 50
Z 55
Z 60
Z 15
Z 50
Z 55
Z 60
Z 15
R parietal
L inf prefrontal
signal change
Age
Age
Col
Col