Bronshtein Tomer

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Proteo-liposomes as a new drug delivery system to
HIV reservoir cells and free virion entrapment
Bronshtein Tomer The Faculty of Biotechnology and
Food Engineering
Advisors
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Current ARTs Why do they fail ?
Anti-Retroviral Therapies
Host Level
Virus-Host Level

• High toxicities
• Low adherence
• Life-time
• administration

• Evolution of
• MDR strains.
• No targeting of
• reservoir cells

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Rational design of a full-scale ART
ENV (gp120)
CD4
co-receptor
CD4 Infected cell
CD4 Uninfected cell
Delivery system must allow drug selection to fit
toxicity adherence demands
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Specific Fusion Between CCR5-conjugated
proteo-liposomes and BHK gp160-expressing Cells
BHK/gp160
FITC
BHK/gp160 CCR5-FITC-PRLPs
FITC
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