Title: Instgra and Tafero EM 12 Months Tablets Uses, MRP Price india.
1INSTGRA AND TAFERO EM 12 MONTHS
2DESCRIPTION
- Instgra Tafero EM tablet are used for treatment
involved in HIV-1 infections. - Instgra tablet are containing Dolutegravir as an
active component whereas Tafero EM tablets are
containing Tenofovir Alafenamide Emtricitabine
as active ingredients. - Instgra is pharmacologically classified as an
integrase inhibitor. - Tafero EM is pharmacologically classified as
nucleoside reverse transcriptase inhibitor.
3DESCRIPTION
- This Instgra Tafero EM combination is approved by
FDA, which may provide better activity against
HIV-1 infections. - Instgra Tafero EM should not have capability of
curing the HIV infection, but it can able to
reduce the development of HIV-1 further to AIDS. - This is a fixed dose combination of one Integrase
inhibitor with two nucleoside reverse
transcriptase inhibitors.
4PROPERTIES
- Brand name Instgra Tafero EM 12 months tablets
- Active components Dolutegravir Tenofovir
Alafenamide Emtricitabine - Strength 50mg 25mg 200mg respectively
- Pack 30 tablets in a container of both products
- Mfg Instgra Emcure Tafero EM - Hetero
- Category Anti-retroviral drugs
5Mechanism of Instgra Tafero EM
- Instgra- Dolutegravir is a competitive to virus
associated to HIV infection. - Dolutegravir is an Integrase strand transferase
inhibitor, which is active against HIV type 1
infection. Dolutegravir binds to the active site
of integrase enzyme, HIV enzyme that helps to
transmit viral genetic material into human
chromosomes. - This binding inhibition prevents integrase
binding to retro virus DNA and causes blockade of
strand transfer step which is required for cell
proliferation process.
6Mechanism of Instgra Tafero EM
- Instgra helps to prevent the HIV type 1 cell
production. - TAF is manufactured as prodrug, which is
conversed into active form inside the body known
as tenofovir. TAF containing cell permeability
activities, through this effect it get penetrate
into the infected cells and changed over as
tenofovir. - Inside the cells, tenofovir is phosphorylated
into tenofovir diphosphate by hydrolysis.
7Mechanism of Instgra Tafero EM
- Tenofovir diphosphate shown anti-retroviral
activity by intercedes into viral DNA and causes
inhibition of chain formation leads to stopping
the viral production. - Emtricitabine into Emtricitabine 5 triphosphate,
this conversion occurs inside the body and causes
chain eliminator effect by struggling with
deoxycytidine 5triphosphate.
8Instgra Tafero EM caused side effects
- Instgra associated side effects
- Hypersensitivity reactions
- Liver toxicity
- Immune reconstitution syndrome
- Insomnia
- Depression
- Abnormal dreams
- Dizziness
- Headache
9- Diarrhea
- Nausea
- Rash
- Fatigue
- Vertigo
- Elevation of
- AST, ALT
- Bilirubin
10- Creatine kinase
- Blood glucose
- Lipase
- Post marketing effects
- Acute liver damage, liver toxicity
- Arthralgia
- Myalgia
- Anxiety
11Tafero EM associated side effects
- Aggravation of hepatitis B
- Immune reconstitution syndrome
- Outbreak or severity of renal impairment
- Lactic acidosis or hepatic steatosis
- Loss of bone mineral density
- Laboratory abnormality
- Virological response alteration
12Pregnancy and lactation
- Pregnancy category of Tafero EM is B Instgra is
B - Instgra Tafero EM uses in pregnancy condition as
cautiously. Counsel the patients about the risk
benefits before starting the treatment with
Instgra Tafero EM. - Breast feeding should not be allowed.
13- Storage and handling
- Instgra container should be stores at 25oC
Tafero EM should be stored below 30oC. - Protect from light
- Keep away from moisture heat
- Missed dose
- In case of missed dose, patient must be consult
with physician and follow the regular dosing
schedule.
14CONACT US
- PHONE NO91 9940472902
- EMAILmillionhealthpharmaceuticals_at_gmail.com
- WEBSITEhttps//pillsbag.com/products/instgra-and-
tafero-em-12-months