Active Ingredients

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KELISEMA S.r.l.

• Active Ingredients
• for the Cosmetic Industry

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Kelisema in the worldOur major partners
UK - Aston Chemicals Ltd
NL/B - Keyser McKay
F - Warwick Adriss SA
D - ICM Barrier Handels GmbH
CH Prochem A.G.
GR - Cellco Chemicals Ltd
E - Delta Tecnica SA
TW - Fairlink Trading Co. Ltd
BRA - Chemy Union Quimica Ltda
AU - Petrofin Ltd
KELISEMA
PH - Eunice Ltd
E - Delta Tecnica SA
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Our products

• Vegetable Protein Derivatives
• Glusol Hydrolyzed Wheat Gluten
• Kelyamin Hydrolyzed Wheat Protein
• Gluplex series Native Wheat Protein - Surfactant
  Complexes
• Glusol 10K High Molecular Weight Hydrolyzed
  Wheat Protein
• Orysol Hydrolyzed Rice Protein
• Oryplex Native Rice Protein - Surfactant
  Complexes
• Maysol Hydrolyzed Corn Protein
• Kelisoy Hydrolyzed Soy Protein
• KeliPro Urtica Hydrolyzed Nettle Protein
• KeliPro Malva Hydrolyzed Mallow Protein

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Our products

• Animal Protein Derivatives
• Kelimilk Hydrolyzed Milk Protein
• Keliwool Hydrolyzed Keratin
• Hydrolyzed Collagen
• Native Collagen 1 Soluble Collagen
• Desacol Desamidocollagen
• Collagen-Hyal Soluble Collagen and Sodium
  Hyaluronate
• Collagen LSS Soluble Collagen and Sodium Lauryl
  Sulfate
• Collagen IMZ Soluble Collagen and Sodium
  Cocoamphoacetate
• Collagen CTC Soluble Collagen and Cetrimonium
  Chloride
• Collagen CCK Soluble Collagen and Potassium
  Cocoate

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Our products

• Specialties
• Thermal Heilmoor Heilmoor Clay
• Shea Butter Butyrospermum Parkii
• Cegaba Carboxyethyl-g-aminobutyric acid
• Sodium Hyaluronate Sodium Hyaluronate
• Kelifluo series Polyperfluoroethers-in-glycerin
  emulsions
• Vegetable Extracts
• Glycolic Extracts
• Hydroglycolic extracts
• Liposoluble extracts
• Propolis
• Aloe Gel

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Protein Derivatives
Effective wheat, soy, rice, corn and leaf protein
derivatives for skin and hair care. Mild
processing preserves amino acid
integrity Traditional and innovative animal
protein derivatives from safe and healthy sources
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Glusol Hydrolyzed Wheat GlutenGeneral
Information

• Description
• High purity wheat protein hydrolysate obtained by
  gentle enzymatic digestion process. Optimum
  molecular weight and strategically placed amino
  acids for outstanding functional and
  technological benefits
• Available types
• Liquid 15 active matter, light colour and odour
• Liquid 35 active matter, light colour and odour
• Powder 95 active matter, preservative free
• Cosmetic Properties And Uses
• Improves skin/eye tolerability of surfactants
• Has hair conditioning and repairing effects
• Helps retaining moisture on hair and skin
• Thickens and stabilises foam in detergent
  formulation

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Glusol Hydrolyzed Wheat GlutenGeneral
Information

• Technical Information Available
• Technical Data Sheet
• Safety Data Sheet
• Primary Skin Irritation Test
• Ocular Irritation Test
• Hair Substantivity Evaluation
• Surfactant Tolerability Improvement Evaluation
• Scavenging Activity Evaluation
• Foaming Properties Evaluation

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Glusol Hydrolyzed Wheat GlutenEffectiveness
highlights

• Surfactant Tolerability Improvement Evaluation
• Glusol reduces the transepidermal water loss
  caused by repeated use of irritant skin
  detergents

Forearm Washing Test 2 daily washings of 5
minutes for 4 weeks with aqueous Sodium Lauryl
Sulfate (SLS) 1 and SLS 1 GLUSOL 1.
Evaluation of the Transepidermal Water Loss
(TEWL).
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Glusol Hydrolyzed Wheat GlutenEffectiveness
highlights

• Scavenging Activity Evaluation
• The free radicals scavenging activity of Glusol
  is much higher than that of a common wheat
  protein hydrolysate

Scavenging Activity Evaluation In vitro test
based on the drop of viscosity of hyaluronic acid
solutions caused by free radicals. Glusol is
compared with a commercial wheat protein
hydrolysate (WPH) with similar molecular weight
and isoelectric point. Special hydrolysis process
used in the preparation of Glusol makes it more
hydrophobic in the terminal positions of the
peptide chains, exposing aromatic groups to the
action of free radicals.
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Kelyamin Hydrolyzed Wheat ProteinGeneral
Information

• Description
• High purity wheat protein hydrolysate obtained by
  the action of a special enzyme pool, which yields
  a high level of free amino acids and small
  peptides
• Specifically featured for hair care and hair
  hygiene products
• Available types
• Liquid 20 active matter, light colour and odour
• Powder 95 active matter, preservative free
• Cosmetic Properties And Uses
• Repairs damaged hair keratin
• Imparts body and volume to the hair strand
• Helps retaining moisture on the hair surface
• Prevents hair damage in waving/colouring
  treatments

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Kelyamin Hydrolyzed Wheat ProteinGeneral
Information

• Technical Information Available
• Technical Data Sheet
• Safety Data Sheet
• Primary Skin Irritation Test
• Hair Substantivity Evaluation
• Hair Hydrating Evaluation
• Hair Protection Evaluation

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Kelyamin Hydrolyzed Wheat ProteinEffectiveness
highlights

• Hair Substantivity Evaluation
• Hair substantivity from shampoo application.
  Comparison of Kelyamin with two commercial wheat
  protein hydrolysates

Hair substantivity from shampoo application Hair
tresses are treated with a simple shampoo
formulation containing 5 of the test products.
Kelyamin is better adsorbed on both virgin and
damaged hair than protein derivatives that do not
contain a significant amount of free amino acids.
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Kelyamin Hydrolyzed Wheat ProteinEffectiveness
highlights

• Hair Moisturisation Evaluation
• Kelyamin helps hair to absorb and retain
  moisture, contributing to the hair health and
  beauty

Evaluation of moisture uptake and release Hair
tresses pre-treated with Kelyamin and untreated
tresses (Control) are incubated at 76 RH.
variation of hair weight is measured after 72
hours this measures the moisture uptake. Tresses
are then incubated at 50 RH and weighted again
after 72 hours this measures the moisture
release.
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Gluplex Series Native Wheat Protein -
Surfactant ComplexesBackground

• Native Wheat Proteins. Why use them in cosmetics
  ?
• They are cheap and easily available from
  renewable sources
• No hydrolysis process their amino acids are not
  subject to degradation
• They have very high molecular weight
• They have very high hydrophobicity
• For these features, they display excellent skin
  protecting properties
• Problems
• They have very low water solubility
• They form a rubber-like matter in aqueous
  environment
• They are easily attacked by microorganisms

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Gluplex Series Native Wheat Protein -
Surfactant Complexes Mechanism and Aim of
Protein-Surfactant Complexation

• Protein-Surfactant complexation
• The chemical bonds generated between protein and
  surfactant molecules are weak but numerous. Main
  contributes are due to hydrophobic and ionic
  bonds
• The protein chains are unfolded without
  hydrolysys
• Primary and secondary structure of the proteins
  are unaffected
• The unfolding is reversible and there is no
  irreversible denaturation
• Proteins solubilisation is achieved
• Hydrophobicity of proteins is increased
• Native Wheat Proteins can be used in cosmetic
  formulations

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Gluplex Series Native Wheat Protein -
Surfactant ComplexesGeneral Information

• Basic features
• Clear, low-coloured solutions
• Protein content 5 minimum
• Surfactant content 5-8
• Ash 1-2
• Full water miscibility
• Compatibility with surfactant solutions
• Major performances
• Surfactant irritancy reduction
• Improvement of foam properties of detergents
• Improvement of plasticity of syndets
• Substantivity to hair and skin
• Easy recovery in finished products

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Gluplex LES Native Wheat Protein - Laureth
Sulfate Complex General Information

• Description
• Aqueous solution of Native Wheat Proteins
  complexed with Sodium Laureth Sulfate.
• Available types
• Liquid 6 protein content
• Cosmetic Properties And Uses
• High molecular weight, high hydrophobic wheat
  proteins show excellent protection against
  surfactant irritancy confer smoothness to the
  skin and prevent swelling of the hair strand on
  detersion
• Technical Information Available
• Technical Data Sheet Ocular Irritation Test
• Safety Data Sheet Surfactant Tolerability
  Evaluation
• Primary Skin Irritation Test Foaming Properties
  Evaluation

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Gluplex LES Native Wheat Protein - Laureth
Sulfate Complex Effectiveness highlights

• Foaming Properties Evaluation
• Small amounts of Native Wheat Proteins improve
  foaming and foam stability of Sodium Laureth
  Sulfate

Foam height for solutions with different
LES/Native Wheat Protein ratio Foam height values
at time 0 (foam expansion) and after 10 minutes
(foam stability). Replacing part of the
surfactant with native wheat proteins produces a
moderate increase of foam stability.
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Gluplex LS Native Wheat Protein - Lauryl
Sulfate Complex General Information

• Description
• Aqueous solution of Native Wheat Proteins
  complexed with Sodium Lauryl Sulfate.
• Available types
• Liquid 5 protein content
• Cosmetic Properties And Uses
• High molecular weight, high hydrophobic wheat
  proteins show excellent protection against
  surfactant irritancy confer smoothness to the
  skin and prevent swelling of the hair strand on
  detersion
• Technical Information Available
• Technical Data Sheet Ocular Irritation Test
• Safety Data Sheet Surfactant Tolerability
  Evaluation
• Primary Skin Irritation Test Foaming Properties
  Evaluation

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Gluplex LS Native Wheat Protein - Lauryl
Sulfate Complex Effectiveness highlights

• Surfactant Tolerability Improvement Evaluation
• Small amounts of Native Wheat Proteins improve
  the skin tolerability of detergent formulations

Collagen membrane test The amount of water
absorbed by an insoluble collagen membrane
immersed in a tenside solution is predictive of
its in vivo irritancy. Two simile detergent
formulation (A and B) were tested. Increasing
amounts of native wheat proteins (Gluplex LS)
reduce the water uptake of the collagen film. The
protein protection is more effective on
formulation A, less mild than formulation B.
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Gluplex OS Native Wheat Protein - Olefin
Sulfonate Complex General Information

• Description
• Aqueous solution of Native Wheat Proteins
  complexed with Sodium C14-16 Olefin Sulfonate.
• Available types
• Liquid 6 protein content
• Cosmetic Properties And Uses
• High molecular weight, high hydrophobic wheat
  proteins show excellent protection against
  surfactant irritancy confer smoothness to the
  skin and prevent swelling of the hair strand on
  detersion
• Technical Information Available
• Technical Data Sheet Cytotoxicity Evaluation
• Safety Data Sheet
• Primary Skin Irritation Test

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Gluplex AC Native Wheat Protein - Cocoate
ComplexGeneral Information

• Description
• Aqueous solution of Native Wheat Proteins
  complexed with Potassium Cocoate. To be used in
  soap-based detergents.
• Available types
• Liquid 6 protein content
• Cosmetic Properties And Uses
• High molecular weight, high hydrophobic wheat
  proteins show excellent protection against
  surfactant irritancy confer smoothness to the
  skin and prevent swelling of the hair strand on
  detersion
• Technical Information Available
• Technical Data Sheet Cytotoxicity Evaluation
• Safety Data Sheet
• Primary Skin Irritation Test

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Orysol Hydrolyzed Rice ProteinGeneral
Information

• Description
• High purity rice protein hydrolysate obtained by
  mild enzymatic hydrolysis of rice seed protein.
  Optimum average molecular weight of 3000 Daltons
  provides high hair/skin substantivity and product
  stability
• Available types
• Liquid 15 active matter, light colour and odour
• Powder 95 active matter, preservative free
• Cosmetic Properties And Uses
• Imparts body and volume to the hair strand
• Helps retaining moisture on the hair surface
• Improves skin/eye tolerability of surfactants
• Thickens and stabilises foam in detergent
  formulation

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Orysol Hydrolyzed Rice ProteinGeneral
Information

• Technical Information Available
• Technical Data Sheet
• Safety Data Sheet
• Primary Skin Irritation Test
• Hair Substantivity Evaluation
• Foaming Properties Evaluation

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Orysol Hydrolyzed Rice ProteinEffectiveness
Highlights

• Hair Substantivity Evaluation
• Orysol peptides are very well adsorbed on normal
  and damaged hair from aqueous solutions at mild
  exposition conditions (30C, 15 minutes)

Hair substantivity from aqueous solutions Up to a
5 protein concentration, an increasing amount of
Orysol peptides is adsorbed onto hair.
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Maysol Hydrolyzed Corn ProteinGeneral
Information

• Description
• High purity corn protein hydrolysate obtained by
  the action of a special enzyme pool, which yields
  a high level of free amino acids (especially
  leucine, proline and sulphur-containing AA) and
  small peptides
• Available types
• Liquid 20 active matter, light colour and odour
• Powder 95 active matter, preservative free
• Cosmetic Properties And Uses
• Imparts body and volume to the hair strand
• Helps retaining moisture on the hair surface
• Thickens and stabilises foam in detergent
  formulation

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Maysol Hydrolyzed Corn ProteinGeneral
Information

• Technical Information Available
• Technical Data Sheet
• Safety Data Sheet
• Primary Skin Irritation Test
• Hair Substantivity Evaluation
• Foaming Properties Evaluation

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Maysol Hydrolyzed Corn ProteinEffectiveness
Highlights

• Hair Substantivity Evaluation
• Maysol peptides are very well adsorbed on normal
  and damaged hair from aqueous solutions at mild
  exposition conditions (30C, 15 minutes)

Hair substantivity from aqueous solutions Up to a
5 protein concentration, an increasing amount of
Maysol peptides is adsorbed onto hair.
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Kelisoy Hydrolyzed Soy ProteinGeneral
Information

• Description
• High purity soy protein hydrolysate obtained by
  mild enzymatic hydrolysis of soy bean protein.
  Optimum average molecular weight of 2000 Daltons
  provides high hair/skin substantivity and product
  stability
• Available types
• Liquid 20 active matter, light colour and odour
• Liquid 40 active matter, light colour and odour
• Powder 95 active matter, preservative free
• Cosmetic Properties And Uses
• Helps retaining moisture on the hair surface
• Improves skin/eye tolerability of surfactants
• Thickens and stabilises foam in detergent
  formulation

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Kelisoy Hydrolyzed Soy ProteinGeneral
Information

• Technical Information Available
• Technical Data Sheet
• Safety Data Sheet
• Primary Skin Irritation Test
• Foaming Properties Evaluation

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Kelisoy Hydrolyzed Soy ProteinEffectiveness
Highlights

• Foaming Properties Evaluation
• Small amounts of Kelisoy improve foaming and foam
  stability of common anionic and amphoteric
  surfactants

Kelisoy at different protein concentration
Cocamidopropyl Betaine at 0.01 Foam height
values at time 0 (foam expansion) and after 5
minutes (foam stability). The foaming
performances of Kelisoy can be used to improve
the foaming efficacy of detergents, and allow to
reduce the amount of surfactants in formulations.
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KeliPro URTICA Hydrolyzed Nettle
ProteinGeneral Information

• Description
• An innovative selective extract from the leaves
  of Urtica dioica (common nettle). Contains the
  concentrated protein fraction, enzymatically
  hydrolyzed, with free amino acids.
• Dedicated to hair care cosmetics, where hair and
  scalp proteinisation is requested
• Available types
• Liquid 10 active matter
• Powder 95 active matter, preservative free
• Cosmetic Properties And Uses
• Repairs damaged hair keratin
• Imparts body and volume to the hair strand
• Helps retaining moisture on the hair surface

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KeliPro MALVA Hydrolyzed Mallow ProteinGeneral
Information

• Description
• An innovative selective extract from the leaves
  of Malva sylvestris (mallow). Contains the
  concentrated protein fraction, enzymatically
  hydrolyzed, with free amino acids.
• Dedicated to skin care cosmetics and cleansing
  products, where proteinisation and moisturisation
  is requested
• Available types
• Liquid 10 active matter
• Powder 95 active matter, preservative free
• Cosmetic Properties And Uses
• Skin conditioner and film-forming agent with
  moisturising, soothening and protecting effects
• Improves skin tolerability of surfactants

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Kelimilk Hydrolyzed Milk ProteinGeneral
Information

• Description
• Partial protein hydrolysate obtained by mild
  enzymatic hydrolysis of food-grade milk casein.
  About 20 of protein content is made of free
  amino acids
• Specifically featured for skin care and skin
  hygiene products
• Available types
• Liquid 15 active matter, light colour and odour
• Powder 95 active matter, preservative free
• Cosmetic Properties And Uses
• Helps retaining moisture on the skin surface
• Reduces the transepidermal water loss
• Improves skin/eye tolerability of surfactants
• Thickens and stabilises foam in detergent
  formulation
• Has a significant scavenging activity on free
  radicals

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Kelimilk Hydrolyzed Milk ProteinGeneral
Information

• Technical Information Available
• Technical Data Sheet
• Safety Data Sheet
• Primary Skin Irritation Test
• Skin Hydration Evaluation
• Scavenging Activity Evaluation

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Kelimilk Hydrolyzed Milk ProteinEffectiveness
Highlights

• Short Term Effects on the Hydration Parameters of
  the Skin
• Kelimilk produces a small increase of hydration,
  and a significant short-term reduction of the
  transepidermal water loss

Evaluation of skin hydration (EC) and
transepidermal water loss (TEWL) Kelimilk was
applied at 2 protein concentration on the skin
of 20 subjects. The short-term reduction of the
TEWL reveals a reinforcement of the skin barrier
function. This can be a valid performance in
protecting and hydrating skin care cosmetics.
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Kelimilk Hydrolyzed Milk ProteinEffectiveness
Highlights

• Scavenging Activity Evaluation
• The free radicals scavenging activity of Kelimilk
  is much higher than that of a common milk protein
  hydrolysate

Scavenging Activity Evaluation In vitro test
based on the drop of viscosity of hyaluronic acid
solutions caused by free radicals. Kelimilk is
compared with a commercial milk protein
hydrolysate (MPH) with similar molecular weight
and isoelectric point. Special hydrolysis process
used in the preparation of Kelimilk makes it more
hydrophobic in the terminal positions of the
peptide chains, exposing aromatic groups to the
action of free radicals.
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Keliwool Hydrolyzed KeratinGeneral Information

• Description
• Partial protein hydrolysate obtained by mild
  enzymatic hydrolysis of virgin Merino wool, with
  food-grade proteases at low temperature and
  neutral pH. Optimum average molecular weight of
  3000 Daltons provides high hair substantivity
• Specifically featured for hair care and hair
  hygiene products
• Available types
• Liquid 20 active matter, light colour and odour
• Powder 95 active matter, preservative free
• Cosmetic Properties And Uses
• Repairs damaged hair keratin
• Imparts body and volume to the hair strand
• Helps retaining moisture on the hair surface
• Prevents hair damage in waving/colouring
  treatments

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Keliwool Hydrolyzed KeratinGeneral Information

• Technical Information Available
• Technical Data Sheet
• Safety Data Sheet
• Primary Skin Irritation Test
• Hair Substantivity Evaluation
• Foaming Properties Evaluation

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Keliwool Hydrolyzed KeratinEffectiveness
highlights

• Hair Substantivity Evaluation
• Keliwool peptides are very well adsorbed on
  normal and damaged hair from aqueous solutions at
  mild exposition conditions (30C, 15 minutes)

Hair substantivity from aqueous solutions In
spite of the relatively high average molecular
size of Keliwool peptides (3 KD), with a low
presence of free amino acids, a good adsorption
on virgin and treated hair is observed. The high
content of Cysteine residues (abt. 7 on total
amino acids) can explain this behaviour.
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Specialties
Natural and synthesised functional substances for
safe and effective cosmetics
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Thermal Heilmoor Clay Thermal HeilmoorGeneral
Information

• Description
• Natural peloid found in millennial deposits
  located at 800-1000 m above sea level in Lower
  Austria, formed by decomposition and slow
  biological maturation of plants. It is manually
  extracted and prepared in place without addition
  of chemical substances
• Available types
• The fibrous and gelatinous dark-brown paste as
  found in nature
• Cosmetic Properties And Uses
• The Thermal Helimoor Clay contains a variety of
  useful cosmetic substances humic acids,
  phytosterols, tritrepenes, phospholipids, amino
  acids and a rich mineral fraction
• It can be used in face and body masks, bath
  products and creams for its revitalising,
  soothening and refreshing properties

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Shea Butter Butyrospermum ParkiiGeneral
Information

• Description
• Natural fat obtained by cold pressing the shea
  nuts and refined without the use of solvents,
  according to the best Italian olive oil tradition
• The chemical-physical and organoleptic
  characteristics of Shea Butter reflect the 100
  natural standard quality. Tests have demonstrated
  its major activity releasing active substances in
  comparison with official ointments
• Available types
• The natural white to yellowish fatty fraction of
  shea nuts
• Cosmetic Properties And Uses
• For all skin-protecting products, sun products
  and for the treatment of skin dryness an ageing

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Sodium Hyaluronate BioGeneral Information

• Description
• It is produced by controlled fermentation of
  selected bacterial strains. Its molecular weight
  is close to the analogous product obtained by
  extraction from cockscomb (mean value of
  1.600.000 Daltons)
• Available types
• Liquid 1 active matter
• Powder 95 active matter
• Cosmetic Properties And Uses
• Hyaluronic acid (and its sodium salt) is known
  for its ability to reversibly bind a large amount
  of water molecules. On the skin surface it forms
  a highly hydrated, protecting layer that can
  maintain moisture for long, since the polymer is
  not absorbed into the skin
• The visco-elastic properties of the hydrated film
  confer a characteristic smoothness and reduce
  skin dryness and roughness

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Cegaba Carboxyethyl-g-aminobutyric acidGeneral
Information

• Description
• Cegaba is a synthesised amino acid, naturally
  found in the cerebral tissue of mammalians,
  especially in the cerebrospinal liquid. This
  molecule is involved in the biosynthetic pathways
  that promote cell growth and cells proliferation
• Available types
• Liquid 2 active matter
• Liquid 10 active matter
• Powder 99 active matter
• Cosmetic Properties And Uses
• In vivo application of Cegaba has showed a
  significant increase of the proliferation rate of
  fibroblasts and the production of collagen fibres
  in the skin.
• A reduction of the hair loss rate has also been
  observed

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Kelifluo Series Predispersed Polyperfluoroethers
EmulsionsGeneral Information

• Description
• A range of anhydrous emulsions of cosmetic grade
  polyperfluoroethers in glycerine. An advantageous
  and practical tool for incorporating
  polyperfluoroethers in aqueous and anhydrous
  cosmetic formulation
• Available types
• Kelifluo 1500 10 and 25
• Kelifluo 3200 10 and 25
• Kelifluo 6250 10 and 25
• Cosmetic Properties And Uses
• Emulsions, oils, gels, detergents, powders and a
  variety of cosmetic formulations can take
  advantage of the unique skin and hair
  protecting/hydrating properties of the
  Polyperfluoroethers contained in Kelifluo
• The Kelifluo predispersions can be used for the
  formulation of aqueous and anhydrous cosmetic
  systems

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KELISEMA S.r.l.

• Via Urago, 13/B
• I-22038 Tavernerio Como
• Tel. [phone]
• Fax [phone]
• www.kelisema.it
• office_at_kelisema.it
• Thanks you for your kind attention !