FORMULATION AND EVALUATION OF CHEWABLE MULTIVITAMIN HERBAL TABLET

1
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FORMULATION AND EVALUATION OF CHEWABLE
MULTIVITAMIN HERBAL TABLET Rutuja
D.Plmpalkar,Maroti M.Jeurkar,RajashreeV.Lode,
Satish 8. Kosalge Hi-Tech College of Phannacy.
Chandrapur. Maharashtra
PO
Poster No A-459
ABSTRACT
OJtdWtTbO\'Cl'AllobjeaM otibtpl'tSCU st1.1d)'
was tonnulatt .md lbt Chew.blMuhMtminHt.-1ta'bM
tpnp11nd byd1rt compieuLo11metbod. Mtthoti The
cNdtdhi.gs 1ZSii.Dthis study \\'trt Am?.
Cbmmnon. Oio.ger.Llq\.Klrice.Tulst aad.Mmlb.afor
tbtt.ft'ectiwfwmWa.tioa.CQIUirisblgtbe chemiul
ccm.stituents like Ascorbk acld.Cimiamaldehyde
.GhlgwotGJycynhizk Kid. tnolarul Mmcho!W'K't
1utd md f\'AlUted rw pre-compress5oopmmnete.Thee
tbe fonnulattd. t.1Net was t\ta?ua-'ted for the
post comprusioa. panmetw.The t.1\gtkt was
t\tahla.ted for 'tight \'.nation. hardness,
thkkntn.. fiiabili1y. disintegration t.est Their
dissoluriotl properties wereassessedbyusing
UVvisfble spemophotommr.Thechtwabletabl\\"m
prepared toensurethat theywereeasilycro.shedbychni
ng, CoachtsiomFrom the abo\-e stndy.\\'t
concludt tha!me multivitamjn herbal tlblets \\'Ht
prepared by direct compremon method migave the
acceptable aodadequate remhs.Tbe tablet sbom
in.swltmeou ttug re.lea.se due to direct
Cltlmpress.ed rabler. l.tssttsAD lbtprmtMH wt
round wizhlD rh4I Jpteitcadon. ktywords
COlDpft\SloD mtchod.Clm\iablthtr\)al
tabkl.MWdvi1amm.Amla.CfnD11mOD.(Hnatr.Liq1.1oric.
.T\WlMtm2la
RISULTS ANDDl5Sa!SKlf'C
Table I Composition of chewablemullivitamio
bttbal tablet (f4)
Th ltk\11ble mltiiwnil b(rbal i.bltl
6gtnnubtM br 41WI ltOllprmitu
(IX'tlJ)d. This tetlll qlt Qf ''
lo Illllld n.laJW
O Vlsamins "'' tbt cupnk (.OIZlpotmds.
bcl.adai fOr tbt normal gro.1bme!rnrtritionaad
mrich 11rerequired insmallqaanrititi intbe
dieiHlM)'canoocbtsymhHHtd by tllt
body.'tbiJ\izamtns anustd
Sr.No I l
lncrcdltb AmlaiAsooroicacid 1 Cit!nGmOt1(citlnGmO
t111klehydt) Gogetjgingerot) Liquorict(gtycyntii
lin) 1\Jlsi(qenol) Mcndll(mrolbol) Lemonjuioe ax S
.tt
Q!aortll)' TW. 8gm I.Sam 0.2.Sgm 0.24gm 0.0. ll'
11dting IJld dryill pnxm.no ff!Y'ixhellli,..,J
pfVP'IY '""''Jlllii6c1c.y 1'.tlb
by d pu""' nl (l!f f A nwl1km111m l(fkil
tMet "'fllth It 111\1 Ike
l1llFurfftnbtd ,...._ mi-H"-"finingtnlip.llion
ofprncnt .'
,The pcM COlllprHSiM po Htt tt.dllefll.
tmtitu, ... v n-,Mid
3

'gt Th ditlllheo11 pmfik w.u 1enni"""1 J1 CC
It 1ims of 15 tr- .singt
r lif)'ilfl l'lbln v.(TC IWNW N
IllCpl)Ni li111i1,
intbtprewnliw Gd.trtmigtmto(lbedeflckncydisease."
5 6 7 3 9
o the preparation contains polyherbslike
AmJ11.cimla.mori,giner. Uqnorlc4. t1.1tsi.me
1nlla widl \gthami.nS likt \'iwniD C.
'itamiD B. Vitamin K. Vitamin B.VitamittA
sho\\fug various phalm11cologjcal
acd\ititiwithmosid.t dtcts
USI'diUllMllftl'llllU uIn 900mloffltr.1ll1alJMll'l
t ft.lid (0.' N H(1) .mlie 1J(n,'Wi6dn"u "ilh
rqib('ttll(..lt( lkcltllllt...OOll ol
sU.UblIptriH11iill!llO. 20, 30, -"), 50 IJld
60 11'1111 mpotAdy. S..pb m fihtrtJ111111g
'9.1tm..ln fib r
0.1 0.0,0.0,,2,ltµ OJJOOOlq.s
ptipcf .d....tfldMtulttifl \N1 1tf \.l
Table No. 2 Pre-Co1npressi. onEva luation
parameters Sr.no Enlnltlc.panmtttn
Formula(f l) Formul9(11) Formult(l'3)
For.(F.C)
OBJl!C'l'1'ES 0 lbe OWTllJ Objti\'t o( tbe
pmecrt study \\'115 to Connulm "1ld nalurte
the Cbe1laOle MQl.tMt.amin Herbal ubler prepared
bydireu ltompressiCID method.
CONCLUSIOS f'f\'111 6c fflt siWy.w ttltllJJlt
111 the c'iblc 111.,dvllt.)lll11 ablnJ
'A'ltR by dittU ltUll(mlllllll .cbod JJld whidi
gll 't the Ptidatltll)' ltmJ
tftM.b OOMSmUlk\lillt- KlnK lbedirtM..bl. , )gt
It w.u llko codldo!dut 'able mliiviuniim hhll
Uhl-1-u prqumlin lb 1onn ltI I ltt ._bl.
-..li(h "'WI tnnillltcp.tliclt 00111pl m
ftt.)nJelli iiig ptllt'iti\'ttfrm5an
fltbx!y. IIhlibn fMll.lbt -I (R) SI'".. an
di!.l1tflPlim (m'll v.ill !I i.l ""limi1t1G.
hli.h 14 -.u dioitt ri. f'OIJ t i 9"11
"ilh llH 911ir(m kfU ia1(UiN of(IOmill.
...ieor._I
.1...4.9 23.(lt)
12l 24.l
O Tbe 't eihation "1ld usessmfi of phy
iikaJ properties oCta'olets.
J)Qlkdou (O'mll T'PJgt'lt. IdmsWy (J\nl) " 0.'5 0.'1 o... U! us o.6! thefide tfbudlhutfiufJ.' .C.ln.'.s..il.l.lk.!.t.. "-ntitk. lfC!t 11r !'fl10 llJ N 00.
Carr's ildtx Jbu!aft'sracio IH 1.lOl 119. ''" 13.7 l.ll7 ll.8 I.I!! II a".1'1Cdwlct t) die ot..iilnl maillll a fduJw)Jrmm ilrlhl' aptf' f'tlclK 1tu. lim.,,,.1!1eillJ"ll
l
O Ako Cblipurposeolmultkisamin tabi.tlsto
6llchen.UIJ'lll.oml1ap1. bypMcfmg healthful
nulriernswblcbarenatmally foundin.bubs.
l1ETBODS-
Table 'No.3Post.Compression \'aluation of Tablets
RfU1"0CES
D Alhhtrtquirtdauditdnlgs\\'8'tconwntdimotbepow
dtrtdlorm IDd lmpnptod "1111 IMollCipioDR ilk
dll,..u, ....,,
Sra (l'lh1111it9,.
r.....(11gt Fon111b(F3) f......(Hgt ,.
m F'onn11l1(F1)
I. G.i11nn KR. To dtwlop a ...,it (UV.\rl
sp
tl methN for du
C'41m.Jli09 '"'' 'tr !lt 'l.lrllulJ. lnl J
lgtf1I fOt11111l11il11 Ru ZOii 2.?Jl
U.lfW tSK t4Klnillgt. ' OOIOI -l!h t\111 s (M
., u
139.
htbrianrs ek. to make gmwles.Tbentbe gmwles
evahuted \\ith pre
Thicl.x(m.m
lt"omNll ll\I ,
l.9
H cml) 6.1 l 6A
'1\' i ll ,'lfillioa J J.S lJ
_ Frilbii iy 0.4 ,!.6 02
'""'Pf''"'"'Jgtlf"""'u.cll .."Plgtddoosily.bulk
dwlly.-.
... ). hi 200 76 32.
1. Slik.lu f_JlmM 8hli.lv l. K r..
Fomwl"Cl... Cklni.1m (If tkli)ll l.tileb
Oiil )l llf hb1ct.ErR.A11JRDl..!O.? l6\ )
1'41ll .a. Sihllfl A 111d Pullk D.
fonmulM'lOll 111d ,-...m of lt1lcw.1blc
Multi\'1Umi11 T.tilrt.lltt J Curt l'klnn Rft
?0119106Hi4 5. lMlmMi L, l.dwrman HA d
Kllalg.ILlb.- dltol) lltd pra.1io 11( 111duwill
ratio..mglieof-repose.compresssbility index. o
These granules 1''fl't lilsed forthe preparation
of lllblen of dtsired lt
shape and du tidn.Jdb.ct ltompmdon mdlod M'lh
tabletpressmachine(HICONanIS09001-2000).'
puDcb
pl11yJrcWit!oo \ f111h,. rlll.iliibillJllMtJOC
I82lg.l.Z'Jt6.JOJ 6. P.JtniillJPH,
S..moll.ltui C.a. 1"1m diu11hcim pofilt 11(
Nll ..-nmilly 111111llblcI""'twltlttln)1i
DNP'R D 101212( 1 3-411 1. llldia
Ph.nuwp.-oi Min or lllXl!!h nd
F'11rnily v..cir .Gownmetu uf
Ttbk No 4, Oisoliiion profileol'ctic-A..'bk
multivitamin hetbal tablcc (F4)
-- D The tablers were f\lilhwed by various
punerers Jib, RJ)tt ,... .,trlnr!rnmtol).hardness
(Rolttt'abltthardmssaeatr). frilbilily(Rocbe
friabilator).disi_.,.n (disimegralion lttsler)
and !Mir dasolul\oc prop..U.S ...,. cs"'1 by
udni USP. (paddle apparanas)'
lrweditnts "drugreltut,time inmlnuu-s
llW!ltl'ublb)- 1bC ..,POOt'!ll ltlcomm
1(jh.Ul_,. WU) p 111sirn.
40 so
10 8.3 9.8
20 20.7 26.6
30 38.8 36,8
60 88A
-
S7.8 72.S
3. UllJINI St11tS PMn11 a'lk OS l' fllli-'.(.
f(gttl11 wtid('t1. 1111 lt411
....
b1dMOI J.- nmdhrt.-ay,llotl.Tilk MD208gt2 1007.
Clnnamaldehyde Glngtrol
14.3 63.7 BLS
.,.. ..,.
73.4 92.1
1Ll 25.7 45.2
12.9 28.1 48.3
67.2
A ('lirlt.(IY!l,t l)( lt'., f ntdlcr.rfwti.11
heffi.Th c ,r of '1il!llUC).'11p!OTiirli
Illebn1iuaJuu 111dnpron.
MyspoiillhabgBill O Df.5.ii 8.
K ,PriDfdofH1gtto.b C ofPlm.,y,
Om r.fl.11foip'l1odiet!.w lbc faaily "cQQflitlt
f1tf ltetc.id YkdsPOl'ltly 'A'ilbit l!snl113
Sl.J"P(f 6i""'l"'._ ialll.td11blt lcilett.
Chart Title
st
100 90 80 s 70
v
/' /-""
/ J' /
,,,.-
/
2 60

--- Add -11-0nnami!ldet.yde _.
Gingerol -gtE-Eogenol
'! so
.,,
At //
40 30 20 10 0
//,,. 0 ......
.
., /
0 20 4() 60 80 Tlmtmln)
Fig I.Crudo drug
Fig2.ln .,.i1ro drug rclrose profile.fOf cbcwabk
multivitamin herbal tablet