EventRelated fMRI to Guide rTMS

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Event-Related fMRIto Guide rTMS

• A. Min Kang
• Randall R. Benson
• Margaret Greenwald

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Stroke Aphasia

• Stroke is 3rd-leading cause of death
• 700,000 strokes/year in the US
• 1/4 have language impairments
• Current treatments
• Spontaneous recovery
• Speech therapy

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Goals

• Identify linguistic network functionally.
• Target rTMS to this network.
• Assess for changes in the functional network, and
  more importantly, clinical improvement.

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Stimuli

• 4 types of events
• Same/Different Judgment
• Non-words (VCV - manner, place, voicing)
• Notes
• Sinewave Combos
• Silence
• Presented over headphones
• Triggered by MRI
• Button-box response
• Software Presentation

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Event-Related fMRI

• TR8000 Delay in TR6000
• TE50 Flip Angle90
• Slices27 Thickness5mm FOV240mm
• Measurements52

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NW vs. Silent
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Notes vs. Silent
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NW vs. Notes