Adverse Reactions

1
Adverse Reactions

• The complete absence of harmful effects, either
  immediate or delayed, when UBI is used property,
  has allowed clinical investigators to use this
  procedure over a period of twenty years and more
  on a single patient.
• Citrate reactions.all typical citrate
  reactions, accompanied by headache, chill,
  temporary fever of not more than 102.0 degrees
  F., and moderate calf muscle spasm. This is less
  than 0.1,
•          Photosensitization (Light) Reactions
  sulfa drugs being the worst offenders. Iodide
  drugs can also be a problem, especially if given
  intravenously. Common non-photosensitive
  medications (ones that are OK to use with UBI)
  include penicillin, aspirin and other
  salicylates, broad-spectrum antibiotics,
  alkaloids, glucose, saline, and whole blood and
  plasma. It is our experience that psychotropic
  medications (pain pills, anxiety and depression
  pills) should be used with caution as UBI may
  increase their effect upon the bodys chemistry.
•          Reactions due to death of bacteria
  (Herxheimers Reaction). This die-off reaction
  is usually similar to flu-like symptoms of
  headache, achiness, tiredness, and just not
  feeling well and usually lasts only several
  days.
•   Exacerbation reactions in chronic
  diseases. Dr. Miley reports that in
  approximately 50 of individuals with bronchial
  asthma, nasal sinusitis and chronic rheumatic
  disease (also in acute rheumatic disease), there
  appears for the first four to five days following
  initial UBI an aggravation of the pre-existing
  symptoms which is usually no more severe than any
  previous severe exacerbation. This is especially
  true following the first application of UBI, much
  less likely to occur after a second UBI, and
  rarely after third.
•   Possibility of producing shock.       
• Other reactions. A rare and mildly
  depressant effect

2
Effects of photon therapy

• influencing the synthesis of prostaglandines
• cracking of albumin molecules
• immunomodulation
• formation of antioxidative scavengers
• influencing the oxyen-binding properties of the
  red blood cells
• metabolic effects

3
Influence on synthesis of prostaglandines
Cascade of arachidonic acid and inhibiting factors
4
Cracking of hydrogen-links in albumin molecules
biological effects - decreased plasma
viscosity - antiinflamatory activity
5
Immunomodulation caused by ultraviolet blood
irradiation

• stimulation of the physiological leucocytolysis
• Normal rate 300000 per second
• stimulation of unspecific phagocytosis
• increase of the humoral germicide activity of the
  blood
• increase of the rate of T4-helper cells

6
Formation of antioxidativescavengers

• short living activated oxygen radicals act as a
  stimulant on blood cells
• blood cells start the production of antioxidative
  enzymatic scavengers
• somatic cells start the production of
  antioxidative enzymatic scavengers after
  retransfusion of the irradiated blood

7
Easier oxygen supply to body tissues

• increased intracellular concentration of 2,3
  diphosphoglycerates in the erythrocytes causes a
  deviation to right at the oxigen binding curve

8
Improvement of hemorheology and hemodynamic
properties

• 1. parameters of the rheology of the blood
• decrease of plasma viscosity
• improvement of the flexibility of erythrocytes
• decrease of the aggregation tendency of red blood
  cells
• decrease of the aggregation tendency of
  thrombocytes
• decrease of plasmatic fibrinogen level
• decrease of plasmatic lipid levels
• 2. Haemodynamic important parameters
• dissolving of vasospastic phenomenons

9
The most important biological effects of the
ultraviolet blood irradiation

• improvement of microcirculation
• antiinflammatory effects
• improvement of the performance of the
  immunological system
• protection against oxidative stress
• improvement of different metabolic activities
• improvement of toxin clearance through connecting
  tissue, liver and kidneys

10
Physiological parameters influenced
byultraviolet blood irradiation

• Biophysical changes
• -improvement of electrophoretical mobility of the
  erythrocytes
• -increase of the electric charge of the
  erythrocytes
• -increase of the chemoluminescence of the blood
• - increase of the ATP-content of the erythrocytes