Mustertitel

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European Molecular Biology Laboratory

• Laboratoire Européen de Biologie Moléculaire
• Europäisches Laboratorium für Molekularbiologie

Dr Iain W. Mattaj Director General
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EMBL Member States

• Austria 1974
• Denmark 1974
• France 1974
• Germany 1974
• Israel 1974
• Italy 1974
• Netherlands 1974
• Sweden 1974
• Switzerland 1974
• United Kingdom 1974
• Finland 1984
• Greece 1984
• Norway 1985
• Spain 1986
• Belgium 1990
• Portugal 1998
• Ireland 2003
• Iceland 2005
• Croatia 2006

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EMBL History

• EMBL was founded in 1974 as a European
  Intergovernmental Research Organisation,
  following the CERN model.
• Sir John Kendrew was the first Director General
• Nobel Prize in Medicine awarded to Christiane
  Nüsslein-Volhard and Eric Wieschaus in 1995
• Today EMBL is one of the worlds foremost life
  science institutions, with e.g. the best non-USA
  research performance in Genetics and Molecular
  Biology (ISI Science Indicators 1992-2002 and
  subsequent)

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EIROforumEMBL is one of seven inter-governmental
research organisations
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EMBLs Five Missions

• Basic Research
• Services to the Member States
• Advanced Training
• Development of New Technologies and Instruments
• Technology Transfer

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EMBL Sites
Heidelberg, Germany Main Laboratory Administration
Hinxton, UK Bioinformatics Hamburg,
Germany Grenoble, France Structural
Biology Monterotondo, Italy Mouse Biology
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EMBL Research Staff Nationalities
Total staff 1400 Over 60 nationalities
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Training at all levels

• Staff - Time-limited contracts
• Scientists at all levels pursue ambitious
  projects in an interdisciplinary, international
  environment.
• Staff leave after 9 years.
• Postdocs - Postdoctoral Program
• Important contributors to the international
  environment, often continue their career in other
  European scientific institutions. (over 200
  postdocs from more than 40 countries)
• Students - International PhD Programme
• Degree-granting authority with strong links to
  national universities

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EMBL International PhD Programme

• Created in 1983
• Can award its own PhD degree since 1997
• Joint PhD degree with 25 universities in 18
  countries
• EMBL fellowships only for students from member
  states
• 60 EMBL fellowships / 40 external fellowships
• Currently 180 students from 39 countries

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Scientific meetings organised by EMBL in 2005
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Biology From Molecules to Organisms

Genome
Embryo
Cell
Protein/DNA
Fruitfly
Mouse
Organism
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Systems Biology

• Systems analysis refers to study of the
  properties generated by interaction between the
  components of a system that are not directly
  predictable from the properties of the individual
  components.
• 2H2 O2 2H2O

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Same components..Different structures
Interphase
Mitosis
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Collaborations between EMBL research groups
Peer Bork EMBL Heidelberg 2003
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Centre for Disease Mechanisms

• Promote basic research related to disease
  throughout EMBL
• Collaborations with medical centres
• Basic research training for MDs
• Dissemination of information
• Organisation of molecular medicine symposia
• Involves all EMBL Units, mouse biology naturally
  a major focus

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EMBL Services to the scientific community

Structural Biology More than 2,000 users / yr
Bioinformatics More than 1,000,000 individual
users / yr
Over 1,000 visiting scientists per year at all
EMBL sites
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EMBL Hamburg and EMBL Grenoble
Synchrotron Radiation Laboratories in
association with DESY, and ESRF
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EMBL/ESRF/DESY are the main providers of SR for
life science applications in Europe
Number of structures from Europe deposited in MSD
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EMBL Hamburg Petra3 Beamlines
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European Bioinformatics Institute
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EMBL-EBI Core Biomolecular Databases
Nucleotide sequence EMBL-Bank
Genomes Ensembl, Integr8
Protein sequence UniProt
Gene expression ArrayExpress
Protein structure MSD
Protein families, motifs and domains InterPro
Chemical entities ChEBI
Protein interactions IntAct
Pathways Reactome
Systems BioModels
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The nucleotide sequence databasesEMBL/Genbank/DDB
J
Europe
EBI
Data are freely deposited
Data are freely exchanged daily
USA
Asia
DDBJ
NCBI
Data are made freely available to all
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EMBL-EBI Development
EMBL-Bank 1982-2005
UniProt etc. 1986-2005
Entries
Megabases

• All EBI Data Resources are growing rapidly
• Staff will grow from 270 members today to 400 in
  2011
• EMBL Council will provide higher of stable
  funding

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Web Requests per Day 1999 2005
Including Ensembl
A few hundred thousand unique users per month
Average per Day
A million unique users per year
Note Ensembl is a joint project with The
Wellcome Trust Sanger Institute. Equivalent
usage data have only been available since 2003.
Quarter Year
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EMBL-EBI Industry programme members
Procter Gamble
Bayer Healthcare
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EMBL Technology Transfer
EMBL
EMBLEM
Start UpCompany
Discovery
Protect/Commercialise
Idea
ETF
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EMBL Spin-Out Companies (Status 30.06.2006)
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EMBL Alumni

• Vast majority of EMBL alumni return to member
  states
• Total number of EMBL alumni 3,733

Scientific Leaders are the most
precious EMBL product
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EU FP6 Projects coordinated by EMBL
ENFIN
FELICS
COMBIO
CISB
NETSENSOR
EuroCSC
SYMBIOmatics

• 15 FP6 projects coordinated by EMBL
• Total number of EU-funded projects is 73 (w/o
  Marie-Curie Actions)

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EMBL Partnerships

• Special cooperations with national institutions
  in EMBL member states
• Build international centres of scientific
  excellence and advanced training modelled on
  EMBL. Includes staff turnover system,
  international recruitment and assessment
• No net transfer of EMBL resources possible
• Do not require EMBL Council approval

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Current EMBL Partnerships

• Partnership for Structural Biology
• EMBL/ESRF/ILL/IBS Grenoble, France
• Molecular Medicine
• University of Heidelberg, Germany
• Marine Molecular Biology
• Sars Centre, Bergen, Norway
• Synchrotron Radiation Applications
• EMBL/DESY, Hamburg, Germany
• EMBL/CRG Systems Biology Research Unit
• CRG, Barcelona, Spain

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EMBL Associate Membership

• Non-European countries
• EMBL Council approved in 2003
• Offers access to EMBLs research infrastructures,
  training programmes and network of European
  contacts
• Australia may become an Associate member?