In vivo derivation of HIV1 resistant - PowerPoint PPT Presentation
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In vivo derivation of HIV1 resistant
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SCID-hu or Rag-hu Mouse. Development of HIV resistant cells. A pHIV7-GFP. U3. R. CMV. EGFP ... Days PI. p24 (pg/ml) Cell control. HIV7-GFP. Triple-R. D. B. HIV7 ... – PowerPoint PPT presentation
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Title: In vivo derivation of HIV1 resistant
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In vivo derivation of HIV-1 resistant Triple-R
transgenic T cells
Ramesh Akkina Colorado State University Fort
Collins, CO, USA
2
(No Transcript)
3
B
A pHIV7-GFP
HIV7-GFP mouse1
Triple-R mouse2
89.7
92.0
RRE FLAP
U3
R
CMV
EGFP
R
U5
CMV
U5
WPRE
?
pHIV-Triple-R-GFP
CD3
U6
sh1
U6
TAR
RZ
VA1
4
SUMMARY
- Triple vector transduced CD34 cells can
differentiate - into normal T cells in vivo
- Transgenic T cells are resistant to HIV-1
infection - Since this vector is safe and effective, human
clinical - trials are underway.
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