UKPDS 38: study design

1
UKPDS 38 study design
Newly diagnosed hypertensive patients with type
2 diabetes (n 1544)
Previous antihypertensive treatment BP 150/85
mm Hg (n 421)
No previous antihypertensive treatment BP
160/90 mm Hg (n 727)
Randomisation
Less tight BP control (n 390)
Tight BP control (n 758)
Avoid ACE inhibitors/ beta-blockers (n 390)
ACE inhibitor to maximum dose (n 400)
Beta-blocker to maximum dose(n 358)
UKPDS 38 BMJ 199831770313
2
UKPDS 38 participant characteristics
UKPDS 38 BMJ 199831770313
3
UKPDS 38 tight control had a greater effect on
blood pressure
Blood pressure (mm Hg)
UKPDS 38 BMJ 199831770313
4
UKPDS 38 relative risk reduction with tight
blood pressure control
Peripheral vascular disease
Microvascular endpoint
Any diabetes endpoint
All-cause mortality
Diabetes death
MI
Stroke
Relative risk reduction tight vs less tight BP
control ()
p lt 0.05 p lt 0.01




UKPDS 38 BMJ 199831770313
5
UKPDS 39 similar effects of beta-blocker and ACE
inhibitor
Any diabetes endpoint
Adapted from BMJ 199831771320
6
UKPDS 39 reasons for non-compliance
non-compliant patients ()
UKPDS 39 BMJ 199831771320