Distribution of HighSensitivity CReactive Protein

1
Distribution of High-Sensitivity C-Reactive
Protein in Korean Healthy Individuals Mina Hur,
Young Kyung Lee, Hee Jung Kang, and Kyu Man
Lee Department of Clinical Pathology, Hallym
University College of Medicine, Seoul, Korea

• INTRODUCTION
• Elevated high-sensitivity C-reactive protein
  (hs-CRP) is a strong predictor of cardiovascular
  events.
• The establishment of population-based cutpoints
  is important for the clinical application of
  hs-CRP assay.
• We investigated the distribution of hs-CRP
  concentrations in Koreans.
• MATERIALS AND METHODS
• The study population consisted of 2,010
  apparently healthy individuals. Except 33
  individuals with hs-CRP levels same or more than
  15 mg/L, 1,977 individuals were enrolled 1,158
  men and 819 women (mean age of 45.5 years).
• We conducted hs-CRP assay with Beckman Coulter
  IMMAGE autoanalyzer.
• RESULTS
• The distribution of hs-CRP was highly skewed,
  and the concentration at 97.5th percentile was
  6.41 mg/L.
• There was no difference of age or gender
  distribution according to the hs-CRP
  concentrations.
• Among the 51 individuals same or above 97.5th
  percentile, only 33 (17/51) showed increased or
  borderline values of total cholesterol.
• The hs-CRP concentrations at higher percentiles
  were relatively low compared with some foreign
  data.
• DISCUSSION