What Is My Risk for Breast Cancer

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What Is My Risk for Breast Cancer?
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(No Transcript)
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Historical Prospective

• 400 BC Hippocrates speculates the nature of
  breast cancer
• Early Romans performed a type of radical
  mastectomy
• 18th Century Discovering role of lymph system
  and spread of disease
• Late 19th Century ovary removal

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Historical Prospective (continued)

• Early 20th Century
• Treatment option One Step Procedure
• Little treatment choice for women
• Middle 20th Century
• Clinical Trials
• One Step Procedure eliminated
• Informed Decisions

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Historical Prospective (continued)

• 1970s
• Screening and early detection
• Increased availability of mammography
• Prevention
• Political activism
• Federally funded research
• Decreased Hospital stays
• Demand for treatment choices
• Social movement
• Increased public awareness
• Decreased stigma

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Prevention Today

• Screening
• Digital Mammograms
• MRI (Magnet Resonances Mammography)
• PET (Positron Emission Tomography)
• Biopsies
• FNA (Fine Needle Aspiration)
• Core Needle
• Stereotactic
• Ultrasound Guided
• Excisional

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Consumer Education Today

• Increased availability of educational resources
• Women partner with treatment team in decision
  making

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Incidence Trends

• 1975-1980 Incidence relatively constant
• 1980-1987 Incidence increased 4 per year
• 1987-2002 Incidence increased 3 a year
• 2003- current Decrease of incidence
• African American women have experienced a
  decreased incidence BUT an increased mortality.

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Mortality Trends

• 1990-2002 Mortality rate decreased 2.3 per
  year
• Estimates 2.3 million breast cancer survivors

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Women Diagnosed

• 88 are alive 5 years after diagnosis
• 80 are alive 10 years after diagnosis
• 71 are alive 15 years after diagnosis
• 63 are alive 20 years after diagnosis

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2007 Estimated New Cases

• 180,510 invasive breast cancer
• 62,030 non-invasive breast cancer
• 40,460 women will die
• 1 of 3 cancer diagnosis for American women
• 2,030 men will be diagnosed in the United States

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Established Risk Factors

• Non-Modifiable Risk Factors
• Women
• Age
• Reproductive Factors
• History Benign Breast Disease
• Family History of Cancer

• Modifiable Risk Factors
• Increased Body Mass
• High Fat Diet
• Sedentary Life-Style
• Alcohol Consumption
• Oral Contraceptives (?)
• Hormone Replacement Therapy
• Radiation Exposure

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What Can You Do?

• Healthy Diet
• Exercise
• Limit Alcohol Consumption
• Discuss Family History with Physician
• Annual Mammogram
• Annual Clinical Breast Exam
• Breast Self-Exam

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What can you do? (continued)

• Genetic Testing
• Become a Political Activist
• Become a Friendship Advocate
• Participate in Clinical Trials

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Oncotype DX

• Examines certain gene patterns in breast tumor
• Estimates persons risk of recurrence
• Commercially available since 2004
• Test results Recurrence score
• 10/lower (30 of patients tested) recurrence
  risk 5 or less with hormonal therapy alone(30
  of patients tested)
• 26/higher (25 of patients tested) recurrence
  risk about 30 with hormonal therapy alone
  reduced possibly 10 with addition of
  chemotherapy (25 of patients tested)
• 11-25 (45 of patient tested) recurrence risk
  10-15 hormonal therapy alone (consider TailorX
  Trial)

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TailorX Trial

• Determines the best individual therapy for women
  with early stage breast cancer
• Eligibility
• early stage breast cancer
• node negative
• Estrogen (ER) or Progesterone (PR) positive
• HER2/new negative
• Tumor measure 1 cm or greater size
• More information
• www.ecog.org
• www.CancerTrialsHelp.org
• http//cancer.gov/clinical-trials
• http//www.oncotypeDX.com
• Source Eastern Cooperative Oncology Group
  (www.ecog.org)

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• At age 34, I thought I was too young for cancer.
  I had an eight year old daughter and a budding
  career, and no time for something like this.. I
  am proud to be approaching my 20th anniversary,
  and am a huge proponent of self exams and regular
  check ups. Women owe it to themselves to do
  this!
• Marti Devich diagnosed aged 34
• UPLIFT Secrets for the Sisterhood of Breast
  Cancer Survivors

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Resources

• American Cancer Society www.cancer.org
• National Institutes of Health www.nih.gov
• www.breastcancer.org
• The Susan G. Komen Breast Cancer Foundation
  www.komen.org
• Y-Me National Breast Cancer Organization
  www.networkofstrength.org
• Cancer Care www.cancercare.org
• Young Survival Coalition www.youngsurvival.org
• National Womens Health Network www.nwhn.org

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Local Resources

• Your States Cancer, Early Detection, and
  Education Program