Personalized Nutrition: also relevant for the silver generation

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Personalized Nutrition also relevant for the
silver generation
Rob Beudeker (rob.beudeker_at_dsm.com) November 29,
2006
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DSM Activities - Clusters
Managing Board
Corporate Staff
Innovation Center
Shared Competence Services
Nutrition
Life Science
Performance Materials
Industrial Chemicals
Animal Nutrition Health
Fine Chemicals
Engineering Plastics (incl. Dyneema)
Fibre Intermediates
Human Nutrition Health
Melamine
Pharmaceutical Products
DSM Nutritional Products
Resins
New Business Development
Agro
Anti-Infectives
Elastomers
Food Specialties
Energy
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Vision 2010 Building on Strengths
Building on Strengths
Market-driven Growth and Innovation
Increased Presence Emerging Economies
Operational Excellence
Value Creation
Organizational Alignment Strengthening HR Base
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Vision 2010 Lets boost innovation!
Innovation Boost

• Stronger business- driven innovation
• Up to 1 billion of sales by 2010
• Building mid to long-term business via
  Emerging Business Areas

• Building on excellent RD
• innovation capabilities
• 30 ? 70 mln additional annual budget for
  selected innovation programs
• 15 of Capex ? New
• Business Development
• 250 Fte extra
• Dedicated effort
• 4 Emerging Business Areas

Input
DSM Innovation Center
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Emerging Business Areas
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Biomedical Materials
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Specialty Packaging
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Personalized Nutrition
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White Biotechnology

• Characteristics of Emerging Business Areas
• Field driven by global mega and technology trends
• Within the Corporate portfolio priorities
• Building upon DSM capabilities (business,
  markets, technology)
• Potential to generate multiple business
  opportunities
• Potential for real impact on DSM profile

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1. What is "Personalized Nutrition" Definition

• "Personalized nutrition is nutrition/supplements
  based on individual dietary recommendations
  derived from knowledge of the individuals
  lifestyle, nutritional status, and/or unique
  genetic makeup and is aimed at promoting health,
  well being, performance and potentially reduce
  risk of health problems"

• Personalized nutrition can be assessed based on 3
  types of tests
• SNP tests identify a persons genetic profile
  and indicate persons predisposition for certain
  health problems
• Biomarker tests for self monitoring of
  improvements
• Questionnaires identify lifestyle, family
  history, and nutrition status to develop some
  dietary recommendation

Single nucleotide polymorphism Source CSD
Personalized Nutrition Team
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Timing is right for the development of
Personalized Nutrition

is in this business
Science Human genome project
Nutrient status SNPs and nutrition

Consumers Health awareness
Demographics Lifestyle
Personalized Nutrition
Food science Communication
Society Drive towards prevention
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Food With a Purpose By Bernadine Healy 2/13/06

• There's an old medical saying that we dig our
  grave with our spoon.

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• Some recent nutrition and health messages towards
  the consumer
• No effect of omega-3 fatty acid on health
• No effect of lowering fat consumption on
  cardiovascular health
• No effect fruit and vegetables on breast cancer
• No effect of antioxidants on health
• Atkins diet may work but actually we dont know
• Is there really no effect of nutrition on health?
• Or are we doing something wrong here?

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Personalized NutritionSingle Nucleotide
Polymorphism (SNP)
What is a SNP? Single base pair change in the
genomic DNA allele. Position must be shared by
at least 1 frequency of a specific population

• These slight genetic variations between human
  beings may predispose some people to chronic
  health problems such as CVD, Diabetes etc.
• The human genome contains 5-10 Million SNPs.
• SNPs may explain why some respond better to
  certain substances and others not.
• SNPs are related to biomarkers (indicators) and
  biomarkers are related to nutritional health
  ingredients

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HDL-C by LIPC Genotypes and Fat Intake
CT
TT
CC
Ordovas et al. Circulation 2002106 2315-2321
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Example of personalized nutrition Can be based
on a SNP analysis

• Optician do eye check

• Consumer visits optician

• The consumer goes to an optician
• While having the eyes checked, a SNP test for
  AMD is performed as well
• The test is sent to the lab that analyses whether
  the consumer has risk of developing AMD
• When the consumer returns to get his
  glasses/contacts, the results are returned
• In case of predisposition, the consumer is
  advised to buy Optisharp (or to take a larger
  dosage of Optisharp)

• Optician take SNP test

• Optician recommend Optisharp

• Lab SNP analysis

SNP single nucleotide polymorphism
The product will reduce risk of developing
AMD. If the consumer does not have the
predisposition she might still develop AMD and
could be advised to take Optisharp anyway to
reduce the general risk of getting AMD
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Consumers largely embrace the concept of
personalized nutrition
51 is favorable towards using genetic
information to obtain nutrition/diet related
recommendations (2005 58) 42 is interested in
using genetic information to obtain
nutrition/diet related recommendations (2005
46) There has been some minor erosion in
perceptions, opportunity remains sizeable ?
public attitudes can shift during debate
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Few consumers are yet experienced with genetic
testing to optimize health
Only 3 of the consumers have asked a doctor
about testing for a specific gene or using
genetic information to understand or optimize
health
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DSM and Personalized Nutrition

• SNPs and/or nutrient status are related to
  biomarkers and biomarkers are linked to DSMs
  nutritional health ingredients
• DSM will further develop IP and know-how in this
  area in cooperation with third parties
• DSM will develop business models with partners in
  the value chain to make this a reality this
  will offer an option for DSM to become a solution
  provider.