Clinical Research Training at Einstein: From K30 CTSA

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Clinical Research Training at Einstein From K30
- CTSA

• Ellie Schoenbaum, MD
• Director CTSA Core
• Research Education, Training Career Development

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Education and training is a cornerstone of our
CTSA

• Has historically been a strong partnership
  between Einstein and Montefiore
• Intersection between the research and educational
  missions of the medical school and medical center
• Strategic value of ground-up approach to
  building clinical and translational research
• Grows out of successful K30 and K12 programs

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THE CRTP (formerly K30)

• BASICS
• Began 1998, two-year MS program with Einstein
  support
• Didactic core parallel mentored research project
  
• Thesis is publishable paper, hypothesis driven
  
• Small class 15 Scholars form a cohort
• Require guarantee of 50 protected time
• MD-MS started in 2005

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The CRTP Curriculum

• Epidemiology, Biostat, Data Analysis, Bioethics
• Grant Writing
• Research Seminars
• Library and data management skills for
  researchers
• Electives
• Biostatistical consultation
• Career Development

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Two Models of Training
Issues Across Schools
Dedicated Faculty
School of Public Health Resources
Medical School Departmental Resources
CTSA Resources
CRTP School of Public Health
CRTP Einstein
Large Course Selection
Curriculum CRTP Specific
MPH, PhD Exposure
other Centers, Grants
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Medical Specialties of 112 CRTP Graduates
2000-2009
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CRTP transformation in progress

• Mentoring groups
• More Epidemiologists and Translational mentors
• Intensified grant writing course focuses on
  career dev K23, foundations
• Support for writing R01s
• Focus on orphan dept or small division with
  little or no clinical research
• Enrollment of Scholars in allied professions

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Career development in the CTSA

• KL2 program provides an exciting template for
  these activities at Einstein
• Strong connection to our CRTP most awardees have
  been CRTP students or graduates
• Links to other funding streams K12 (e.g., Child
  Neurology, Cancer, HIV/Drug Use, Nephrology),
  T32s, K23s, Empire Clinical Research
  Investigator Program

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PhD in Clinical Investigation a cultural change

• Administratively integrated into Grad Div, which
  offers PhD in Biomedical Sciences
• ICTR provides academic home for students
• Courses developed to introduce clinical research
  approach
• Epidemiology, human genetics, overview clinical
  research
• Recruitment challenging dismantling silos
• Core CRTP curriculum serves as basic courses
• Considering recruiting from med school applicants
  for MD/PhD

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Definition of Translational Research

• Translational research fosters the
  multidirectional integration of basic research,
  patient-oriented research, and population-based
  research, with the long-term aim of improving the
  health of the public.

__________________ Rubio DM, Schoenbaum EE, Lee
LS et al. An Educational Framework for
Translational Research. Acad Med. (in press)
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Einsteins Model for Translational Research
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Evaluating effectiveness

• Need metrics for educational programs
• Course evaluations need more emphasis on
  competency development than student response
• Outcome metrics could be rethought in context of
  CTSA vision
• Not just publication, but impact on health
• Not just PI, but team science
• Connection to community (inside, outside)
• Looking to link with CTSA national effort in
  conjunction with our internal evaluation services

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Thanks to

• Paul Marantz, MD and Harry Shamoon, MD
• Aileen McGinn, MS PhD
• Ann Marie McCauley
• Stacey Sodlosky
• And of course the Einstein CTSA