PubChem and Entrez G' W' A' Milne

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PubChem and EntrezG. W. A. Milne
30 May, 2006
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Biochemistry, especially genomics, is poorly
served by the current for-profit methods of
publication
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Biochemistry, especially genomics, is poorly
served by the current for-profit methods of
publication
Open Access information freely accessible on
the Web is demanded by the biomedical community
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Biochemistry, especially genomics, is poorly
served by the current for-profit methods of
publication
Open Access information freely accessible on
the Web is demanded by the biomedical community
NIH/NLM has developed an Open Access system
for dissemination of information
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PubChem and Entrez
The new system -
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PubChem and Entrez
The new system -
A Searchable System of Bibliographic and Numeric
Databases from the Biomedical Sciences
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On the Web and free
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Data
PubChem has data for over 10 million chemicals
Access is free of charge
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Literature
PubMed has citations, abstracts for over 11
million papers
PubMed Central has full text for nearly 2 million
papers
Access to both is free of charge
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The Federal Research Public Access Act of 2006,
proposed last week by Senators Joseph I.
Lieberman, Democrat of Connecticut, and John
Republican of Texas, would require 11 government
agencies to publish online any articles that
contained research financed with federal grants.
If enacted, the measure would require that the
articles be accessible online without charge
within six months of their initial publication in
a scholarly journal.
The Federal Research Public Access Act of 2006,
proposed last week by Senators Joseph I.
Lieberman, Democrat of Connecticut, and John
Cornyn, Republican of Texas, would require 11
government agencies to publish online any
articles that contained research financed with
federal grants. If enacted, the measure would
require that the articles be accessible online
without charge within six months of their initial
publication in a scholarly journal.  
The Federal Research Public Access Act of 2006,
proposed last week by Senators Joseph I.
Lieberman, Democrat of Connecticut, and of Texas,
would require 11 government agencies to publish
online any articles that contained research
financed with federal grants. If enacted, the
measure would require that the articles be
accessible online without charge within six
months of their initial publication in a
scholarly journal.
The Federal Research Public Access Act of 2006,
proposed last week by Senators Joseph I.
Lieberman, Democrat of Connecticut, and John f
Texas, would require 11 government agencies to
publish online any articles that contained
research financed with federal grants. If
enacted, the measure would require that the
articles be accessible online without charge
within six months of their initial publication in
a scholarly journal.
 
NYT 4/8/06
NYT 5/8/06
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Entrez Goals
Link chemistry to biomedical data
Link chemical, biomedical data to literature
--- chemistry, biochemistry, enzymology,
genetics, taxonomy, bioassay, medicine
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PubChem Goals

• Archive published molecular structure and
  bioassay data
• Provide search, retrieval and data analysis
  tools to optimize utility of these results

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PubChem Contents

• Chemical structures, names
• Bioassay records
• Computed similar structures
• Links to biomedical literature
• Links to 3D protein-ligand structures

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URLs
Entrez Search http//www.ncbi.nlm.nih.gov/gquer
y/gquery.fcgiPubchem Search http//pubchem.nc
bi.nlm.nih.gov/PubChem Structure Search
http//pubchem.ncbi.nlm.nih.gov/search/compounds
earch.html This Seminar
http//www.phm.com/Pubchem or

http//www.sicmm.org/Pubchem
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Chemical Structure
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Similar Structures
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Biological Activity
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Protein-ligand Structures
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Proteomics, Genetics
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