ETPGAHBASIC RESEARCH

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ETPGAH-BASIC RESEARCH

• Prof. Paul-Pierre Pastoret
• BBSRC

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(No Transcript)
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WORKING GROUP 1

• BASIC RESEARCH AND MAPPING

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MEMBERSHIP CRITERIA

• Scientific disciplines
• Member countries
• Companiess representatives
• Institutess representatives
• Academias representatives
• Regulatory Agenciess representative
• Chief veterinary Officerss representative
• Gender and scientific excellence
• Restricted number
• No HOBBY HORSE

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INTERACTIONS

• Working Group 1 Basic Research and Mapping
• Working Group 2 Technology Transfer
• Working Group 3 Horizontal Issues

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WORKING GROUP1MEMBERSHIP

• Chair Paul-Pierre Pastoret (BBSRC, UK)
• Vice-Chair Jose M. Sanchez-Viscaino (Facultad de
  Veterinaria, Madrid, Spain)
• MEMBERS
• Oya Alpar (London School of Pharmacy,UK)
• Jean-Christophe Audonnet (Merial, France)
• Sandor Belak (Uppsala Diag.Lab.,Sweden)
• Jozef Bires (CVO, Slovakia)
• Ilaria Capua (OFFLU, Italy)
• Kris De Clercq (CODA-CERVA, Belgium)
• Frank Koenen (CODA-CERVA, Belgium)
• Benauda Kadra/ Eva Balla (CEVA, Hungary)

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MEMBERSHIP, continued

• Reinhardt Kroker (BLV, Germany)
• Dieter Lütticken/ Danny Goovaerts (Intervet, The
  Netherlands)
• Dominique Martinez (CIRAD-EMVT, France)
• Quintin McKellar (Royal Veterinary College, UK)
• Thomas Mettenleiter (Friedrich Loeffler
  Institute, Germany)
• Ivan Minkov (University of Plovdiv, Bulgaria)
• Volker Moennig (Tierärztliche Hochschule
  Hannover, Germany)
• Ivan Morrison (University of Edinburgh, UK)
• François Moutou (AFSSA, France)
• Jan Van Oirschot (ESVV, The Netherlands)

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MEMBERSHIP, continued

• David Paton/ J. Bashiruddin (IAH-OIE, UK)
• Joan Plana-Duran ( Fort Dodge, Spain)
• Polly Roy (London School of Hygiene and Tropical
  Medicine, UK)
• Christian Schelp (Bommeli, Switzerland)
• Alejandro Schudel/ Christiane Bruschke
  (OIE-International)
• Michael J. Witty (Pfizer, UK)

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OBSERVERS

• Noel Tordo (Pasteur Institute, Paris, France)
• Hervé Bourhy (Pasteur Institute, Paris, France)
• Joseph Vercruysse (University of Ghent, Belgium)
• Joris Vandeputte (Trivarop, Consultant)
• Jim Scudamore (Consultant)

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REMIT

• Beware of the gaps
• No Hobby horse
• Generic versus Specific
• Focus on Major conditions
• Emphasis on Zoonosis
• Infections rather than Diseases
• Include Wildlife
• Think globally and for the future (horizon
  scanning)
• Take Livestock revolution and foreseeable trends
  in livestock production into account

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SCIENTIFIC DISCIPLINES

• Infectiology
• Immunology
• Epidemiology
• Vaccinology
• Pharmacology
• Omics

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OPTIONS and TOOLS

• Basic research
• Vaccines
• Diagnosis
• Pharmaceuticals
• Selection/Transgenesis
• Regulation/Policy
• Infrastructures

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Working Group 1, 1rst Meeting11 October 2005

• Agenda
• Research needs on transboundary and emerging
  animal infections
• Research needs in animal health to protect public
  health (Dieter Lütticken)
• Research needs for developing countries
  (Dominique Martinez)
• Research needs in Epidemiology of animal diseases
  (François Moutou)
• Research needs in fundamental Immunology of
  domestic animals (Ivan Morrison)
• New developments in Molecular Biology to be
  applied in animal health (Thomas Mettenleiter)
• Research needs in animal vaccinology and
  diagnostics (Jean-Christophe Audonnet)

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FOUR DISCUSSION GROUPS

• Basic Research and Immunology (Chair
• Thomas Mettenleiter)
• Research needs for developping countries (Chair
  Dominique Martinez)
• Research needs in Epidemiology and Infectious
  Diseases (Chair Dieter Lütticken)
• Research needs in animal Vaccinology, Therapy and
  Diagnosis (Chair Jean-Christophe Audonnet)

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MAIN CONCLUSIONS ARISING FROM THE DISCUSSIONS

• The development of new control strategies depends
  on the understanding of host-pathogen
  interactions (integrated biology)
• Sustainability of scientific expertises in basic
  research is key for the success
• Analysis of the gaps in knowledge and expertise
  is a prerequisite
• A scientific approach for priorities appraisal
  needs to be developed
• Bio-informatics will be a backbone for future
  scientific developments

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MAIN CONCLUSIONS, continued

• Cooperation with developing countries for
  reciprocal benefit
• Development of predictive epidemiology with
  increased focus on
• wildlife
• Selection of animals good responders to
  vaccination
• Setting up a European Centre for Animal Diseases
  Control
• Availability of P4 biosecure facilities for large
  animals challenge studies
• Legal support to develop vaccines for minor
  species
• Training of academic scientists about regulatory
  requirements

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WORKING GROUP 1, 2d MEETING,28 November 2005

• AGENDA
• Description of the draft Scientific Research
  Agenda (SRA)
• Comments on the draft Agenda
• Definition of generic and specific priorities

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RATIONALE FOR THE CHOICES

• Host-Pathogen interactions (Thomas Mettenleiter)
• Immunology (Ian Morrison)
• Vaccines, Diagnosis and Therapy (Jean-Christophe
  Audonnet)
• Epidemiology and Public Health (François Moutou)

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PRIORITIES FOR GENERIC RESEARCH

• Development of bio-informatics and bio-statistics
• Animal Genomics
• Immunological toolbox
• Epidemiology including wildlife
• Arthropod vectors of pathogens
• Biosecure facilities for target animals challenge
  studies

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PRIORITIES FOR GENERIC RESEARCH, continued

• Cell biology
• Target challenge models
• Ecology-Ethology
• Interaction between proteins (antivirals)
• Training (pharmacology, toxicology,
  histopathology,)
• Networking (availability of reagents,
  epidemio-surveillance)

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CRITERIA FOR SELECTION

• Economic Impact
• Zoonotic Impact (Food-borne and non Food-borne)
• Impact on Developing Countries
• Major gaps of knowledge in Host-Pathogen
  interactions, Epidemiology or Immunology
• Gaps in Prevention, Diagnosis, Therapy
• Lack of incentive for investment by the private
  sector

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LIST OF 15 PRIORITY DISEASES

• African swine fever
• Rabies (urban rabies in developing countries)
• Influenza
• Foot-and-Mouth disease
• Bluetongue
• Pestivirus infections
• Gastro-intestinal parasitism
• Contagious Bovine PleuroPneumonia (CBPP)

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PRIORITY DISEASES, continued

• Food-borne Zoonosis (Salmonella, Campylobacter,
  E.coli, Cryptosporidium,)
• TSE (ante-mortem diagnosis)
• Mastitis
• Tick-borne diseases
• Q Fever
• Mycobacteriosis (TB and para-TB)
• Neglected Zoonosis (Trypanosomiasis,
  Leshmaniosis, Swine cysticercosis,)

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DISEASES TO INCLUDE IN SURVEILLANCE PROGRAMME

• Ruminant poxvirus infections
• Rift-valley fever
• West-Nile virus infection
• Peste des Petits Ruminants
• Swine Vesicular Disease
• African Horse Sickness
• Food-borne viral Diseases
• Emerging infections

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RECOMMENDATIONS FOR BASIC RESEARCH

• 1. Take a strategic overview of the fundamental
  Sciences in the European Union to assess whether
  there is sufficient capacity and expertise
  necessary to support research and technologies
  needed to develop new tools to control diseases

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RECOMMENDATIONS FOR BASIC RESEARCH, continued

• 2. Develop an EU wide strategy to enhance the
  capacity and expertise in the fundamental
  sciences and consider whether specific science
  programmes are needed to develop expertise in
  each relevant area

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RECOMMENDATIONS FOR BASIC RESEACH, continued

• 3. Target research funding to the individual
  areas identified as a priority for research
  critical to the development of vaccines,
  pharmaceuticals and diagnostic tests

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RECOMMENDATIONS FOR BASIC RESEARCH, continued

• 4. Strengthen collaboration between the resarch
  organisations working on the fundamental sciences

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RECOMMENDATIONS FOR BASIC RESEARCH, continued

• 5.Establish and support a centre for epidemiology
  and animal infectious diseases (preferably not
  virtual) at an European level

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• THANK YOU FOR YOUR ATTENTION