The life styles of bacteriophage l

1
The life styles of bacteriophage l
2
The genetic map of the phage regulatory region
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A brief review The l genetic network
4
A brief review The l genetic network
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A brief review The l genetic network

• Additional regulatory steps
• N is autoregulated by a negative feedback
  loop.
• Cro represses expression from the pL and pR
  promoters.
• Cro repression leads to negative feedback
  loop.

6
A brief review The l genetic network
Lytic pathway Q antiterminates transcripts
initiated at the pR promoter leading to lytic
gene expression.
7
A brief review The l genetic network

• Lysogenic pathway
• CIII stabilizes the rapidly degraded CII by
  inhibition of the Hfl protease.
• CII activates integrase synthesis.
• CII activates CI synthesis.
• CI represses the pL and pR promoters.
• CI autoregulates its expression from pM.